Conserved Protein Domain Family
M48C_Oma1_like

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cd07342: M48C_Oma1_like 
M48C peptidase, integral membrane endopeptidase
This subfamily contains peptidase M48C Oma1 (also called mitochondrial metalloendopeptidase OMA1) protease homologs that are mostly uncharacterized. Oma1 is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins; it cleaves a misfolded polytopic membrane protein at multiple sites. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Oma1 is part of highly conserved mitochondrial metallopeptidases, with homologs present in higher eukaryotes, eubacteria and archaebacteria, all containing the zinc binding motif (HEXXH). It forms a high molecular mass complex in the inner membrane, possibly a homo-hexamer.
Statistics
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PSSM-Id: 320701
View PSSM: cd07342
Aligned: 36 rows
Threshold Bit Score: 149.331
Threshold Setting Gi: 550927373
Created: 11-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      #   #              
gi 647595600  159 DIMRAGEAQTLTldmevICNYPVNVVssdavNAYADGKAIYITSGMMRFtetDEELATVIGHELAHNQMdHIGKQSNNrm 238
gi 644226559  152 ELERGGRRLAITvdgvpGCVSRVEIRpseayNGWADGITAQLSSAMVDFtqdDDELATVIAHEMAHNILrHRVRLNEAgv 231
gi 686473627  150 LALRTGAGRTVSvmpkpGCASDFRVEanekpGAVADGRMVLVNQGLIEFspdDEELAAAIAHELAHNILrHRARLDAAgv 229
gi 489131412  145 AMLDTGKAPVRIvp-vvGCATDFRVDardrpDGAADGRLVVISAGLAQFakdDAELAAAVAHELAHNILgHRARLDAAgv 223
gi 332013603  175 TVLRHGQRRDVTvaaqpGCRSRFEMLmgpglTASADGDIVQIGSRFFERf-dDRMIAVVVGHEFSHNILrHRERLDAAgv 253
gi 806908830  145 TVERAGTPVTYDlvpdrGCRSQVQLEtsdtlNAGADGTMISIGLEAAAAaqnDDELAISIAHEMAHNILaHRDRLDRAgv 224
gi 815671417  133 VTRGGGEARDIAinapaGCRSRFEVLlgpamTAQADGKVVQIGVRFFERy-rDDEVAVIVAHELAHNILrHRVRLEAAgv 211
gi 929694986  159 TLIRDGRTFDVAvtgtpACRSRFELRpsgeyGASADGDIVGITVPMLDFmldDDELAAILAHEMAHNLLeHRRRLNAAgv 238
gi 946230094  164 EVIRAGAPIKVTvqpvpACRSRFELLlssgyNARADGTMVQISSQFLEEy-tPEQAAAAVAHEFSHNILhHRDRLEARgv 242
gi 1044806976 160 GLRRGGEQITASvqpvpVCRSRFEVVwndktVAHSDGEIIQISSSLLDRf-dDGQLAVLLAHELAHTILrHRDRLEAAdv 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #                                         #    
gi 647595600  239 lgvilgaivtvatgvdvtnlggnmgagaFSQDFEAEADYVGIYATARAGYDikqAPNFWRRMGaehpagiAHGASHPNta 318
gi 644226559  232 srglfa---------------qvgrnarLTRATEIEADRLGVYLMARAGFDphaAARFWDRLLrqhgagiLADGTHLGrr 296
gi 686473627  230 drglak---------------qfgrnarMFKQTEIEADRLSVWLLAGAGYDpaaAARFWSRFGqrkgrplFQASTHPSwr 294
gi 489131412  224 drgllq---------------qfgrnarLFKQTEIEADRLSPWLMANAGYDpraAVRFWTAFGqragrplLQAGTHPRwq 288
gi 332013603  254 krglls---------------efgrngrLFRQTETEADLLGVHLMRNAGYDpqdAVRFWREHGgevdggiFRSRTHPSss 318
gi 806908830  225 erdakv---------------rnpqdalEIRKTEDEADLLGLYLVAQAGYDidvAPPYWERLSg------AGDATHAGgt 283
gi 815671417  212 kggllg---------------eigrnasLGQAAELEADQLGVVLLYNAGYDsasAARFWQQRGgdidgglFRSRTHPAtk 276
gi 929694986  239 qrgllq---------------qfgrnarLTLATEIEADRLSIWLMANAGYDpagAVRFWTRYGrqrgkgiFSAPTHYRwk 303
gi 946230094  243 dfgmls---------------gfgtnvkYFRQTELQADLLSVYLLANAGYSpraSIDFWKRFGpskaggiFRSRSHPHwr 307
gi 1044806976 239 anglla---------------efgrnrrLNRQAEDEADLLSIHLLYNAGFDprtAPDFWRGAGkkldpglLRSRIYRSpr 303
                         170
                  ....*....|...
Feature 1                      
gi 647595600  319 NRYLALDKAVQEI 331
gi 644226559  297 KQVALVTGVAHEI 309
gi 686473627  295 DRVAALEDEAAAI 307
gi 489131412  289 DRAASIEREVRAI 301
gi 332013603  319 ARADAVAAEIATI 331
gi 806908830  284 ERRAMTQRIVDEI 296
gi 815671417  277 RRVAAIDTAAASL 289
gi 929694986  304 KRVGLFEEEMAKL 316
gi 946230094  308 DRVATLEAEIAKL 320
gi 1044806976 304 QRAAAMDKEIERL 316

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