Conserved Protein Domain Family
M48A_Ste24p-like

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cd07345: M48A_Ste24p-like 
Peptidase M48 subfamily A-like, putative CaaX prenyl protease
This family contains peptidase family M48 subfamily A-like CaaX prenyl protease 1, most of which are uncharacterized. Some of these contain tetratricopeptide (TPR) repeats at the C-terminus. Proteins in this family contain the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. They are thought to be possibly associated with the endoplasmic reticulum (ER), regardless of whether their genes possess the conventional signal motif (KKXX) in the C-terminal. These proteins putatively remove the C-terminal three residues of farnesylated proteins proteolytically.
Statistics
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PSSM-Id: 320704
View PSSM: cd07345
Aligned: 41 rows
Threshold Bit Score: 160.139
Threshold Setting Gi: 381387228
Created: 27-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 223691600  50 LSILALFVFaadlyilklkl----alagfppfevFPTLEALVFLLVFLGYLVIVWTSAWGVQKQFFSGTVSKK------- 118
gi 374849360  73 LFVGVVLVEfislillswgy----vvrrvwglgtWILLDEILLLSPLMLSLVAVWWGLYPAEKILHDSLRRRDstpfw-- 146
gi 657898146  78 LAVAAACVLafgwgwrvqse----llifwdgearLLPFAELAVPLPYFVLLVGGWLVYYDAERALHRVLHLGErpfw--- 150
gi 503331135  82 AEVALLGVFawtihglnwpat--vawltgrigvvVPLLNETLVLAPYIIGLGLIWWGLYLGERAVCPPRWRPRrle---- 155
gi 657611097  46 HRLLSQYVFgvvmlatciaaplsmvrylrplghaGGAIAVVLPALVVVGLTLAHQAIQHPVLREIRQTAETRR------- 118
gi 503233427  50 CIILAIGLYfppviglgild---kvmeplaehisSPFLGALIFMGVFITPLLISIMLTILVASKIEVEVKGLN------- 119
gi 283436277 107 LGVTVAMVYvigwpavv---------rsnwdlarFPLVDDLLVLAPTLLSLAGLWSGLFFLQRERSWQVHRALalqsptl 177
gi 381387228  90 LLGFAAGLAcgwaeav------------rawigdPWIFDDAILLAPPLAATALMDAAAWPLVRRFREATLLGRadaglpi 157
gi 410831691  10 IAVGILLIVeqfhhpi------------airvisSKFICFIFYWLTAVALYVYNQFIYYEIYKQIQQLEATKR------- 70
gi 771516295  54 LIIIVSIFIsgyamani---------lkymritrNKLLAIIIAVVLIFFFTLLDQILSYETYKKLRNVDLNLS------- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 223691600 119 ---------SFVLSNISFSLPALLPWFLLSIMADFIQILPFEGprtfl-----atplgEILYVIFFLFAVASFGPFLIQk 184
gi 374849360 147 -----srtgYVIFQARTHSAILILPMLLYVTVQEMGSQLDSALmeqfrqw--lpfyyfTGISVLAVLVVLLILPWMLVRi 219
gi 657898146 151 ------srsAYLLYNLRQFALMVMLPVLLWVAQQALGRYLPDItrt---------lvyKLGSLAVVPGLILLMPLLMKPl 215
gi 503331135 156 ------svrAYLIAKARRSLAIVLPLVAAIALMQQLFERLLPEgfqg--------gsvHLAAMGLVGLGSLTALPLLVKr 221
gi 657611097 119 ---------EQAGQALRWLALILVPVVLWNLAVVWIPDSIQNAldnn--------rlmSLLLPLVFVTVLNLLLPLFLRw 181
gi 503233427 120 ---------IKTWETVKGILKAFAFLLLPGIVWLGIYLNLPEKirns--------tlaSFGVFVIYILSFFALSPYLTRf 182
gi 283436277 178 prwsralprYLVLQAKHQLLLVLAPALVVLAISEFMATENRADtar---------wpvAVWVFPLLLVALPLLPFVLTRm 248
gi 381387228 158 --hpvpgrwAYVGSRFRGGVGILGVPLALVLGWNQALEAALAAapdgsplpppgsspaLLLAAAGSLLAVALCPPLLVRv 235
gi 410831691  71 ---------EALLMSIKYIIYITIVPVVVKLIYLTPFIQQLEQqge----------lmKFVIWGSILFGASIFSPYLIKi 131
gi 771516295 118 ---------DILKITLRQLLIIVFPTLLVLTGRNIIREIIRTNevm----------dyIIWVLLTLISILIYPYTLKLLl 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 223691600 185 lwGCSSLDPGPTRERIESLCNLagigcADILKWELFgGSMITAGVMGLvsrfRYILVTPALVsLMTPREVDAVIAHEIGH 264
gi 374849360 220 -wQTESLPQGELRDLLESTARRlgfryTDFRVWHTQ-NNIANALVTGIlpwpRYVVFSDSLLqALSSYELVAVLGHEIGH 297
gi 657898146 216 -lGLRPMPPGPVRDRFVALARRlefrcADFLLWPTH-GAIANAFITGLlprvRYVVFTDRILdDLPPDELDAVFGHEVGH 293
gi 503331135 222 mwPYHPLEPGPLRNRLLDLARRrrvriSEIHVWQTD-HTLATAAVTGFgfgpRYVFLTDALLeHLDDERIVAVFGHELSH 300
gi 657611097 182 tlRARPMPASALRDALEAFALRaglgkVGLYVWSSRrGRQANALVSGYl--hKHIYLADYLLdHLTQEEVEAVIAHEIGH 259
gi 503233427 183 -fGKPRQVPEPLRTELLKFCESlgfkvRDIRVTGKKeYKIANAGVTGIlpwaRYIFITEYMLeTFEPEEIKAVIAHEIGH 261
gi 283436277 249 -wRTTPIPASPLRDRLLACTRDmhtqvRDILLWQTS-GSVANALVVGVtnrlSYVLLTDALVaELSADELEVVVRHELAH 326
gi 381387228 236 -vPTMPLPIGPLRDELLAFLAAekvraRRLRVWLTG-SAVANAALVGPlpclRYLMLSDRLLeSLPREELLGVLAHETGH 313
gi 410831691 132 ifNAIPLQDEQLRRELMNEIHRhqlkgVKIYQIPTSkFKYANAAASGIl--aKKIFILDYLMkHLTVEEVKCVLAHEIGH 209
gi 771516295 179 --RAKPCKSHDLIIELSSFLKNhniqkANIYIWPSKnEKIANAYICGLi--aKYIFISDYLVyNLDMDEIKAVLAHEIGH 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 223691600 265 VKK-HHIHFYLFFFAGYIACVYALFDPllvlvyamdplswfvsfvgmeqetfstlvfsLILILLFILYFRFVFGFFMRNF 343
gi 374849360 298 VRR-WHLPLYVGLCMLAAVSGVQLLSLrwpglepylvallyr--lpsdladwrqwlhlAFSMTVLWGYIWLIFGYVSRHC 374
gi 657898146 294 ARH-GHIWLYAGFLALSLSVLAALVLFveqvietgtseevg---rlrealkgfktwaaLPPVVLVTAYLFVVFGALSRWC 369
gi 503331135 301 LHR-RHIRWFGVALLGAVGLAALVNWLidrsggldva-----------slfwgeavrqAPAALVLGGVVFFVFGAMSRSF 368
gi 657611097 260 VKR-HHLWIRLLLVVGWVPLVEAIGWLgdtyapd-----------------apdwaavGVLLLLFFAYFGFTVRYVSRVQ 321
gi 503233427 262 IKG-RHLWINALIAIGWFGFWMGIVFAliklgvdi----------------lspvvffGVFFSAYIIYFVVIQGKISLRN 324
gi 283436277 327 LRR-WHLPLRMGVLVLPIVGWLVLSQLlaaemaqfaawl-------tsmgisetlqltVVTPALLALHAVVVVGALARLL 398
gi 381387228 314 ARH-RHLLWLGGWAIASAVLLALTLDAavprl---------------------pvaaeWPLVGLAVAAWAAAFGWVSRRV 371
gi 410831691 210 IKKfHLEIKTACYLLSCIVFLFSLSQLnrlmhwlstqpi-------naeyaylglilaITVFIPLMLLLLYVNRLISRML 282
gi 771516295 255 WKK-HHIEIRILLMLFTYPLFLIVSSFldylatfkn--------------inipipigIFITFLVFFIYISMILGIFRKQ 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                                      #        
gi 223691600 344 ERQADTYVFSLLGsg---------------------------rsLIDTFYKIAr-----fSRTSPDRPNWHHFNIT-QRI 390
gi 374849360 375 EREADVYGCLAAScgnaqcsdhrenrsl--aksgdslcptgiriFISALEKVAd-----iNGLPRTQWSWRHGSIA-RRI 446
gi 657898146 370 ERQADLFGCRAMSca---------------------------dpTCTGHDEKTvy---atGGRCLCPTGIRTFARAlDRV 419
gi 503331135 369 ERQADLDGARALSqtrsaadstdpahapplagpddppdryglevFIATLRQVAa-----iNHLSVRRWTWRHGRMA-DRI 442
gi 657611097 322 ERQADAYVLQLGIpa---------------------------pvFISALLKLArlnqatvRLHRWDERLQTHPSFA-RRI 373
gi 503233427 325 EFKADEFAAKVIGke----------------------------tVIKTLEKLAevnltpkKTGKWFGFLSFHPSIE-ERI 375
gi 283436277 399 EHDADLLACRQSGeplrld-------------------pertrhFAAALSTLVp------PGSESWFSRWLHPSTT-RRI 452
gi 381387228 372 EAQADAHAAAAMSdhlgpatpda-----------aaftpagvaaIADALARVAr-----lAGSSQRRRSFRHGSIA-SRR 434
gi 410831691 283 ELQADCYAIRSGInv---------------------------evYISMLNKLMelshaqkEPNKLSSAFQTHPSFQ-KSI 334
gi 771516295 320 EYAADKYAIMTGVky---------------------------evYRSALSKLAllndlskHTNIICEKLQTHPHIE-RRI 371

                 ....*..
Feature 1               
gi 223691600 391 NFLERCE 397
gi 374849360 447 AYLEKLQ 453
gi 657898146 420 RDLNGLD 426
gi 503331135 443 AFLERVR 449
gi 657611097 374 EWIAQRA 380
gi 503233427 376 RHLEEVA 382
gi 283436277 453 ALLNASL 459
gi 381387228 435 AALLRLL 441
gi 410831691 335 ETVRQCA 341
gi 771516295 372 YYITNIY 378

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