3F5C


Conserved Protein Domain Family
NR_LBD_Dax1

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cd07350: NR_LBD_Dax1 
Click on image for an interactive view with Cn3D
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
The ligand binding domain of the DAX1 protein: DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) is a nuclear receptor with a typical ligand binding domain, but lacks the DNA binding domain. DAX1 plays an important role in the normal development of several hormone-producing tissues. Duplications of the region of the X chromosome containing DAX1 cause dosage sensitive sex reversal. DAX1 acts as a global repressor of many nuclear receptors, including SF-1, LRH-1, ERR, ER, AR and PR. DAX1 can form homodimer and heterodimerizes with its alternatively spliced isoform DAX1A and other nuclear receptors such as SHP, ERalpha and SF-1.
Statistics
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PSSM-Id: 132764
View PSSM: cd07350
Aligned: 7 rows
Threshold Bit Score: 297.504
Threshold Setting Gi: 149642520
Created: 31-Mar-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputativeheterotrimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 ##   #                                 #   #  #        
3F5C_B        29 PRAPWWDASPgvqrl---itlkdPQVVCEAASAGLLKTLRFVKYLPCFQILPLDQQLVLVRSCWAPLLMLELAQDHLHFE 105
gi 75057169  231 PRAPWWDTSSgalrp---valknPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFE 307
gi 82133753   68 QEVRQQACSCgstrrr--gvlrsPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLVLIRSGWAPLLVLGLAQDRVDFE 145
gi 82175017   28 PRGSGPGCSCgargrgrgrsraaAGGERAAAAAVLVKTLRFVKGVPCFQQLPLAEQLVLVRAAWAPLLVLGLAQDGVALP 107
gi 149642520  78 LDNSALLQLIpsfiislrgrervWEGARARARAVLLKTQRFVQGVPCFLALPPADRLVLLRAAWTPLLALGLAQDGVVPG 157
gi 139002557  43 TGVYGQGCSCgaqkk---vslksPQLTCKAASAVLVKTLRFVKNVPCFQELPLDDQLLLVRSCWAPLLVLGLAQDKVDFE 119
gi 19310197   44 SRLYGQGCSCgsqkk---vtlksPQVTCKAASAVLVKTLRFVKSVPCFQELPLEDQLLLVRSCWAPLLVLGLAQDKVNFE 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                               #                         
3F5C_B       106 MMEIPETNttQEMLTtrrqetegpepaepqate----qpqmvsaeaghllpaaaVQAIKSFFFKCWsLNIDTKEYAYLKG 181
gi 75057169  308 TVEVSEPSmlQKILTtrrretggdeplpvptlq----hhlappaearkvpsasqVQAIKCFLSKCWsLNISTKEYAYLKG 383
gi 82133753  146 TTETVEPSmlQRILTgcpdrqseavgg---------------qnrgapgvsvvdIEAIKAFLKKCWsVDISTKEYAYLKG 210
gi 82175017  108 AHEAAQPSmlQRILTarppp-----------------------------ppaadLQALHGVLAKCWsLDIGPKEYAYLKG 158
gi 149642520 158 GLQAPRSSvlRSILTrrppp-----------------------------aaprhLRAVEAFLAHCWtLGVTSREYAYLKG 208
gi 139002557 120 TVETSEPSmlQRILTtrqegerkqqlqqqdsl------lgspqhklshlpsaaeIRWIKEFLDKCWnLDISTKEYAYLKG 193
gi 19310197  121 TVETSEPSmlQRILTnsqggenklhhehseqdflfgnsqhqqhnklsqlpsateIRWIKEFLEKCWsLAISTKEYAYLKG 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3F5C_B       182 TVLFNPDLPGlqcVKYIEGLQWRTQQILTEHIrmmqreyqiRSAELNSALFLLRFINSDVVTELFFRPIIGavsMDDMML 261
gi 75057169  384 TVLFNPDVPGlqcVKYIQGLQWGTQQILSEHTrmthqgphdRFIELNSTLFLLRFINANVIAELFFRPIIGtvsMDDMML 463
gi 82133753  211 AVLFNPDLEGlrcLHYIQSLRREAHQALNEHVrlihredttRFAKLLIALSMLRAISPPVVAQLFFRPVIGtvnIEEVLM 290
gi 82175017  159 AVLFNPDLPGlqcTQYIQGLQREAQQALNEHVrlihrgdqaRFAKLNIALSLLRSINANVIAELFFRPIIGtvnMDDMLL 238
gi 149642520 209 TVLFNPDLPGlrsVRYVRGLHLEARRALDEQVrsvhrgdhaRVAQLNAALGLLTAIPAHAVAELFFRPVVGavaVDDVLL 288
gi 139002557 194 IVLFNPELPGlhcIQYIQGLQHEAQQALNEHIkmihrweqtRFSKLMIVLSFLRTVNANAIAELFFRPIIGsvnMDDMLL 273
gi 19310197  201 IVLFNPGLPGlhcAQYIQGLQQEAHQALNEHVkmiqrwdnaRFTKLIIVLSLLRSINANAISELFFRPIIGtvnMDDMLL 280

                 .
Feature 1         
3F5C_B       262 E 262
gi 75057169  464 E 464
gi 82133753  291 E 291
gi 82175017  239 E 239
gi 149642520 289 E 289
gi 139002557 274 E 274
gi 19310197  281 E 281

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