Conserved Protein Domain Family
Cby_like

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cd07429: Cby_like 
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.
Statistics
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PSSM-Id: 143631
View PSSM: cd07429
Aligned: 19 rows
Threshold Bit Score: 104.343
Threshold Setting Gi: 157135889
Created: 30-Sep-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656942     1 MPFFGNTFSPKKTPPRKsasl----snlHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGvs---------- 66
gi 110763024   1 MPLFSNKFSPKKTPTRKvgvf----lanKNFSPKRIEKELGPNIGPIRLKLGDQETVFESGSWIPESGki---------- 66
gi 189240455   1 MPLFGSKFAPKQPPLRK-----------FANNVSEDLDELVSGQRSVQVRLGSQELVFENGDWIPESGes---------- 59
gi 256574796  81 ADHISRPFSPRRPPLRRmpsl----stfYLLDHNTRQAELGLAYGAPCMRLSNQAFVFRGGRWTTESQlartrs-----p 151
gi 149412135  29 DHFSRRRFSPRRPPLRRisfm----stfYLLDHRTRQAELGLSYGPPRTRLSRQTLIFLEGRWVNDGEaahsp------- 97
gi 220903164   1 MPLFNKKFESKPIPVRQg----------RCNIGHPVATEDLDDFRQISLTLGNKELRFADGIWMHSTRk----------- 59
gi 157135889   1 MPIFTKKFAPKVAPPRTa----------RLNIGCPPQQEDLDEFRNIRLNLLDKQLCFVDGVWMSAAApgggssgmtaal 70
gi 195998766   1 MPLFSRNGLGGLISQKKprqg----qqnVATPQPNNLDPVSLENGAIKVKLGHNVLCYEDGLWTSEVGgs---------- 66
gi 156404608   1 MPLFGKKKSPRRKLEAGssnl----sksNVSLADTSVDPNDPNAALVKLKLGGNELVFRDGEWCSDATg----------- 65
gi 221131080   1 MPLFGKPSFKASRKVPKrradagssntiQLADKDTLDPNLDFSQIPLQLSLGGRKMMFQNGSWISRDAgse--------- 71
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 7656942    67 --ggVDRREVQRLRr-RNQQLEEENNLLRLKVDILLDMLSESTAE 108
gi 110763024  67 ---gGTYKENEKLKk-EIKRLEDENNLLKLKFEVLLDMLTQTTAE 107
gi 189240455  60 ---gTAHKSNQRLRk-KIQELQEENNMLRLKYAVMLNMLTQTTAE 100
gi 256574796 152 llsrTAWGWKAQVQrsKSQVLLEENNYLKLQQELLIDMLTETMAR 196
gi 149412135  98 plapAGGRSPARLA--KVQSLLEENNYLKLQQELLMDMLTEATAR 140
gi 220903164  60 ----GDVDDMLRLNk-KFRALEEENNMCNLKIEVMLDLLAERDGT 99
gi 157135889  71 psnaSTIDDLLRMKr-RLKTLEQENNLYQVKLDVLLDLLTENITS 114
gi 195998766  67 --sgNTLKEITRIKk-HNIQLAEENNLLKYKINVLLDMLAVSNAD 108
gi 156404608  66 ---aVKGSADANLQk-INNQLKEENNYLKYKIDVLLDMLAATTAD 106
gi 221131080  72 -sslQESDEATALKe-KILILEEERNLLKYKIELLLDMLAVSQSD 114
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