1IJX


Conserved Protein Domain Family
CRD_SFRP3

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cd07441: CRD_SFRP3 
Click on image for an interactive view with Cn3D
Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist.
The cysteine-rich domain (CRD) is an essential part of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), which plays important roles in embryogenesis and postnatal development as an antagonist of Wnt proteins, key players in a number of fundamental cellular processes. SFRPs antagonize the activation of Wnt signaling by binding to the CRD domains of frizzled proteins (Fz), thereby preventing Wnt proteins from binding to these receptors. SFRPs are also known to have functions unrelated to Wnt, as enhancers of procollagen cleavage by the TLD proteinases. SFRPs and Fz proteins both contain CRD domains, but SFRPs lack the seven-pass transmembrane domain which is an integral part of Fzs. SFRP3 regulates Wnt signaling activity in bone development and homeostasis. It is also involved in the control of planar cell polarity.
Statistics
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PSSM-Id: 143550
View PSSM: cd07441
Aligned: 4 rows
Threshold Bit Score: 257.671
Threshold Setting Gi: 15826370
Created: 23-Jan-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Wnt
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # ### ###                                                             
1IJX_A        2 SAACEPVRIPLCKSLPWEMTKMPNHLHHsTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHepiKPCKSV 81
gi 61216844  24 AAACEPVRIPLCKPLPWNMTKMPNHLHHsTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHepiKPCKSV 103
gi 82123985  28 CASCEPVRIPMCKSMPWNMTKMPNHLHHsTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHepiKPCKSV 107
gi 18858723  28 AASCEPIRIPMCKSMPWNMTKMPNHLHHsTQANAVLAIEQFEGLLGTQCSADLLFFLCAMYAPICTIDFQHdpiKPCKSV 107
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
Feature 1                                                     
1IJX_A       82 CERARQGCEPILIKYRHSWPesLACDELPVYDRGVCISPEAIVTAD 127
gi 61216844 104 CERARAGCEPVLIRYRHAWPesLACDELPLYDRGVCISPEAIVTAE 149
gi 82123985 108 CERARAGCEPILIKYRHTWPesLACEELPVYDRGVCISPEAIVTVE 153
gi 18858723 108 CERAKCGCEPVMKRYNHTWPesLACEELPVYDRGVCISPEAIVKAE 153

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