Conserved Protein Domain Family
CRD_FZ6

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cd07450: CRD_FZ6 
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 6 (Fz6) receptor, and is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. CRD containing Fzs have been found in diverse species from amoebas to mammals. 10 different frizzled proteins are found in vertebrata. Frizzled 6 (Fz6) is expressed in the skin and hair follicles and controls hair patterning in mammals using a Fz-dependent tissue polarity system, which is similar to the one that patterns the Drosophila cuticle.
Statistics
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PSSM-Id: 143559
View PSSM: cd07450
Aligned: 7 rows
Threshold Bit Score: 231.193
Threshold Setting Gi: 41056221
Created: 23-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # ### ###                                                            
gi 75055132   21 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLplANLECSPNIETFLCKAFVPTCTEQIHVv------P 94
gi 215273986  20 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLplANLECSPNIETFLCKAFVPTCIEQIHVv------P 93
gi 17433027   20 SLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLhlANLECSPNIEMFLCQAFIPTCTEQIHVv------L 93
gi 54035111   23 SLFTCEPITVPRCTGMNYNMTFFPNLMEHYDQDIAALRMEPFLplLNLHCSPEVHMFLCRAFVPECTEPKHIt------M 96
gi 118087250  21 SLFTCEPITISRCSRMPYNMTFFPNIMGHYDQDTAALQMEPFLtlMNLHCSPDVHTFLCKAFVPACLEQVHVi------H 94
gi 47218546   23 SLFTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATNMKPFMplIKLRCSPGVHHFLCQAFFPACFENVGS-------R 95
gi 41056221   20 TLFTCEPVQVQWCLDMPYNTTFFPNMLEHYDQDIAAVRMKEFMplVSVRCSPDAHLFLCQAFVPECRTHSHSqththvlR 99
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                     
gi 75055132   95 PCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPv--------TFDPHTEFLGP 147
gi 215273986  94 PCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPv--------TFDPHTEFLGP 146
gi 17433027   94 PCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVPv--------TSHPHTELSGP 146
gi 54035111   97 PCRSLCERVHSDCKNLIETFGITWPAELECDRMRDCNYSQSkvggpngpqDARQHPEKVSK 157
gi 118087250  95 PCRNLCEKVYSDCKQLIDTFGITWPEELECSRLVNCDETAPata----pvTTNAHGTQKTP 151
gi 47218546   96 PCREECKTVLSDCKDNIQVFGISWPPELQCDKLDPCFLTRDd--------TTPETPPATSP 148
gi 41056221  100 PCRERCERVRSDCRAVMHTFDISWPSELQCERLESCGGSAVdv------tTAGRSGAGSSP 154

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