Conserved Protein Domain Family
CRD_SMO

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cd07451: CRD_SMO 
Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein.
The cysteine-rich domain (CRD) is part of the smoothened receptor (Smo), an integral membrane protein and one of the key players in the Hedgehog (Hh) signaling pathway, critical for development, cell growth and migration, as well as stem cell maintenance. The CRD of Smo is conserved in vertebrates and can also be identified in invertebrates. The precise function of the CRD in Smo is unknown. Mutations in the Drosophila CRD disrupt Smo activity in vivo, while deletion of the CRD in mammalian cells does not seem to affect the activity of overexpressed Smo.
Statistics
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PSSM-Id: 143560
View PSSM: cd07451
Aligned: 13 rows
Threshold Bit Score: 210.687
Threshold Setting Gi: 212509055
Created: 27-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:
  • Comment:Inferred by similarity to other members of the CRD_FZ superfamily.
  • Comment:Wnt binding surface annotation based on mutation analysis of CRD domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           # ##    ###                                   
gi 51094856    66 RAAPCEPLRY-----------------------NVCLGSVLPYGATSTLLAgd------sdSQEEAHGKLVLWSGLRNAP 116
gi 6226140     36 RPAACERLRF-----------------------GSCLGSALPYAHTSTLLAad------sgSQEEAHGKLLLWSGLRNAP 86
gi 13194566    39 KTTTCEPLKY-----------------------NICLGSVLPYALTSTVLAed------ssSQDEVHDKLSLWSGLRNAP 89
gi 6226141     86 RRARCYPTSNa---------------------tNTCFGSKLPYELSSLDLTdf-------hTEKELNDKLNDYYALKHVP 137
gi 15077855    30 KSTTCEVLKY-----------------------NTCLGSPLPYTHTSLILAed------seTQEEAFEKLAMWSGLRNAP 80
gi 118343996   27 SQTGCVDLGN-----------------------TTCFGSDLPYSQTSFELVtd------adTLAGVKEKLLLWSGIRAVP 77
gi 146324972   42 RPAACTPLPAn---------------------mTQCLGTEISHTYISLSLAnd------stTIQEVNERLVMWKGLRNVP 94
gi 66532483   150 RHAKCVEIQK-----------------------NTCMGTRLPYTTTTLELIpe------hiTQDIIEEKLHVLQTLRHVP 200
gi 193634190   20 CSTPQVLLGLsksksklqycerphsrcldmnhsLSCLGVKLPYTSTSTDLVpd------aeTPEEAQERLHYWQGLKKVP 93
gi 197276682   53 KPAKCQLLNY-----------------------TTCMGMKLPYFSTTLELTdl-------tTQEKVQEKLHHYKYLRFIP 102
gi 212509055   50 CRKSAECTSSn----------------------LTCFGVPLPYSDISSDVVvdlfkspelqNFHNLQQELNKWEILRKVP 107
gi 156542961   63 KPAKCVKMIN-----------------------TTCLGATLPYDTTSLDLMpk------ytTQEMIMEKLHILRGLEHIP 113
gi 156381257   22 GSYKCEPLKE-----------------------QTCLGEKLDYHYTTTELVtd------ssSQDQVKKNLEKWEGLKFLP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 51094856   117 RCWAVIQPLLCAVYMPKCENd----rVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFp---EGCTNEVQn-IKFN 188
gi 6226140     87 RCWDVIQPLLCAVYMPKCEDg----qVELPSQTLCQATRAPCTIVERERGWPDFLKCTPDRFp---EGCPNEVQn-IKFN 158
gi 13194566    90 RCWDAIRPLLCAVYMPKCEGg----kVELPSQGLCQTTRVPCAIVARERGWPDFLKCTTDYFp---EGCPNEVQn-IKFN 161
gi 6226141    138 KCWAAIQPFLCAVFKPKCEKingedmVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFp---TKCTNGARg-MKFN 213
gi 15077855    81 RCWAVIQPLLCAVYMPKCENg----kVELPSQHLCQATRNPCSIVERERGWPNFLKCENKEQf--pKGCQNEVQk-LKFN 153
gi 118343996   78 LCWDAIQPLLCSVYFPECGEn----kIQLIDRKVCQATRQPCKIVEVEYGWPDFLRCDNNDVy--aDQCESPSTk-LLKF 150
gi 146324972   95 KCWEVVQPLLCALYMPKCEDg----rVELPSFDMCTVVQSPCRIVELERGWPHFLQCNEEHMpr-eCSEPNSYKa-VTFN 168
gi 66532483   201 KCWAVVQPLLCSIFMPKCINd----tVDLPSQEMCKMVSGPCRIVFNHTIWPSFVKCENTDLf--pRLCKNDIRe-LKFN 273
gi 193634190   94 KCWAAIQPLLCALYMPNCENs----sLHLPPQEMCKLIENHCQILKIENSWPAEFNCENDTIyp-aKLCKNDLRelKFNS 168
gi 197276682  103 KCWAVIQPFLCALYMPKCENg----kVDLPSREMCQLTLKPCKMFYNSSIFPKFLNCDDERIf--sSNCKNDVQe-LRFN 175
gi 212509055  108 KCWQTLQPFLCALYLPKCEYd----tVYLLSQERCKYTMSTCKILKEPLFAATFPSINCDATeffpRTCKNDVKd-LRSN 182
gi 156542961  114 KCWAVVQPFLCSLFLPKCVNd----tVDLPSQEMCKVVSGPCKILLNHTIWPNFIKCDNEELf--sRSCKSEIRe-LKFN 186
gi 156381257   73 KCWEVLQPFLCQIYKPKCKNg----sVELPCREQCFATRKPCSVVESYRRWPEFLRCDKLPE----GNCNGTLK--KLHL 142

                  ....*...
Feature 1                 
gi 51094856   189 SSGQCEVP 196
gi 6226140    159 SSGQCEAP 166
gi 13194566   162 SSGQCEAP 169
gi 6226141    214 GTGQCLSP 221
gi 15077855   154 TSGQCEAP 161
gi 118343996  151 NASGCEPP 158
gi 146324972  169 LTGGCEPP 176
gi 66532483   274 ISSKCLKP 281
gi 193634190  169 TAGRCESP 176
gi 197276682  176 TTGFCMEP 183
gi 212509055  183 LSGECISP 190
gi 156542961  187 TSSSCLYP 194
gi 156381257  143 NESACKAP 150

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