Conserved Protein Domain Family
CRD_sizzled

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cd07452: CRD_sizzled 
Cysteine-rich domain of the sizzled protein.
The cysteine-rich domain (CRD) is an essential part of the sizzled protein, which regulates bone morphogenetic protein (Bmp) signaling by stabilizing chordin, and plays a critical role in the patterning of vertebrate and invertebrate embryos. Sizzled also functions in the ventral region as a Wnt inhibitor and modulates canonical Wnt signaling. Sizzled proteins belong to the secreted frizzled-related protein family (SFRP), and have be identified in the genomes of birds, fishes and frogs, but not mammals.
Statistics
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PSSM-Id: 143561
View PSSM: cd07452
Aligned: 4 rows
Threshold Bit Score: 256.732
Threshold Setting Gi: 95132415
Created: 27-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         # ### ###                                                      
gi 82123409   19 FDIGLSTKCVTIPTEMAMCNDVGYSEMRLPNLMGHtNMAEVVPKSAEWQNLLQTGCHPYARTFLCSLFAPVCLDTFIQPC 98
gi 118082168  22 FDIGLSTKCVVIPKEMDMCHEIGYSEMRLPNLMGHtSMAEVVLKSTTWQHLVHTDCHPHVRMFLCSLFAPICLDTFIHPC 101
gi 14280010   21 FDIQLSTKCVPVPREMGLCQDVGYSEMRLPNLLGQrSVAEVLPSSAQWLRLLHTGCHPHARTFLCSLFAPICLDTFIQPC 100
gi 95132415   19 FDLGQTTRCVPIPPQMSVCQDVPYSEMRLPNLLGHgSLEEAAPRSDDLRTLLHTGCHPQARAFVCSLIAPVCLDRFIQPC 98
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                     
gi 82123409   99 RSMCVAVRDSCAPVLACHGHSWPESLDCDRFPagedmCLDTLSKEYQYsYKELPKPSCQGC 159
gi 118082168 102 RSMCVGVRDSCAPVLACHGHTWPESLDCNRFPadedmCLASLTKEYKYlHKVLPKPACQTC 162
gi 14280010  101 RSMCVSVRDSCAPVLACHGQSWPESLDCDRFPagegmCLASISKEDQYiYREFPKPTCQEC 161
gi 95132415   99 RSVCLAVKESCSPVLACHGHSWPESLNCERFPeq-ddCLTPLPKHISAfSKEFPQPACQSC 158

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