Conserved Protein Domain Family
CRD_crescent

?
cd07453: CRD_crescent 
Cysteine-rich domain of the crescent protein.
The cysteine-rich domain (CRD) is an essential part of the crescent protein, a member of the secreted frizzled-related protein (SFRP) family, which regulates convergent extension movements (CEMs) during gastrulation and neurulation. Xenopus laevis crescent efficiently forms inhibitory complexes with Wnt5a and Wnt11, but this effect is cancelled in the presence of another member of the SFRP family, Frzb1. A potential role for Crescent in head formation is to regulate a non-canonical Wnt pathway positively in the adjacent posterior mesoderm, and negatively in the overlying anterior neuroectoderm.
Statistics
?
PSSM-Id: 143562
View PSSM: cd07453
Aligned: 3 rows
Threshold Bit Score: 252.169
Threshold Setting Gi: 38198627
Created: 12-Feb-2009
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  # ### ###                                                            
gi 7839501   36 SRCMRIPKsmALCYDIGYSEMRIPNLLEHETMAEAIQQSSSWLPLLARECHPDARIFLCSLFAPICF--DRYIFPCRSLC 113
gi 82122791  42 SSCTAIPRsmALCYDIGYSEMRIPNLLEHETMPEVIQQSSSWLPLLARECHPDARIFLCSLFAPICL--DRLIYPCRSLC 119
gi 38198627  26 APCMRIPKsmALCYDIGYCEMRIPNHLEHEQMAEVLQQEWRWVPLLNKECSPDARIFLCCLFAPICWplDSPIYPCRSVC 105
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                
gi 7839501  114 EAVRSSCAPIMACYGYPWPEILKCDKFPEDHGmCISTITNDTGSTRRTVPRASCRDC 170
gi 82122791 120 EAVKRSCAPVMACYGYPWPEILNCNKFPADHElCIAAVSTDESSSSRRMPRASCKDC 176
gi 38198627 106 EAVRSGCAPLMKAYGFTWPESLHCDKFPVDNDlCISPQFINTLEPEDVKVCPPCEME 162

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap