1IJY


Conserved Protein Domain Family
CRD_FZ5_like

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cd07456: CRD_FZ5_like 
Click on image for an interactive view with Cn3D
Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 5 (Fz5) and frizzled 8 (Fz8) receptors, and similar proteins. This domain is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143565
View PSSM: cd07456
Aligned: 11 rows
Threshold Bit Score: 233.059
Threshold Setting Gi: 86563956
Created: 24-Apr-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Wnt
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # ### ###                                                               
1IJY_A         9 ACQEITVPLCKGIgYEYTYMPNqFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLeDYKKPLPPCRSVCER 88
gi 20454907   63 RCEEITIPMCRGIgYNMTSFPNeMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLeDYHKPLPVCRSVCER 142
gi 148224295  32 VCQEITVPMCKGIgYNHTYMPNqFNHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLCSMYTPICLpDYRKPLPPCRSVCER 111
gi 241152585   1 RCEDITIPMCKGIgYNQTSMPNqFNQDTQDEAGMEVHQFWPLVEIQCSDDLKFFLCSLYTPICMeEYAGSVPACRSVCER 80
gi 169823466  97 KCIPIEIPLCKNIgYNLTYMPNaFNHETQEEAGLEVHQFYPLVEINCSEDLRLFLCSMYTPICLpTWHYRLTACKSLCES 176
gi 86563956   24 KCEQITIPLCKGIgYNMTSFPNsYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQeNYDKPILPCMELCVE 103
gi 83318899   37 KCEPITVPMCRDIgYNMTYMPNhFNHDSQEEAGLEVHQFYPLVEIQCSPDLKFFLCSMYTPICLaDYHKPLMACRSVCER 116
gi 219448493  30 VCEEVTIPMCKGI-YNYTYMPNkFHHQNQDEAGLEVHQFWPLVEIQCSPALKFFLCSMYAPICLeDYDHPLPVCKNVCQM 108
gi 156389432  28 KCEEITIPMCRGIgYNLTYMPNmFNHDTQAEAALEVHQFWPLVEIQCSPDLRFFLCSMYAPLCEkHYDKDLPPCRSVCER 107
gi 62122563   35 RCEDLVMPLCRGLwYNRTRMPNmFNHETQEEAGHQAQQFMYLVTIKCSPDLHFFLCSIYTPICVeNYDKPLPPCRSICQR 114
gi 47212559   17 VCEPITVPMCKGIgYNLTYMPNqFNHDTQEEVGLEVHQFWPLVRIRCSPDLLFFLCSMYTPICLpDYRKPLPPCRSVCER 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
Feature 1                                                   
1IJY_A        89 AKAGCAPLMRQYGFAWPDRMRCDRLPeqgn---pdtlCMDYER 128
gi 20454907  143 ARSGCAPIMQQYSFEWPERMACEHLPlhgd---pdnlCMEQPS 182
gi 148224295 112 AKAGCSPLMRKYGFAWPERMNCDRLPehgd---pdtlCMYYNW 151
gi 241152585  81 ARAGCAPIMRQYGFAWPERMNCDALPqygd---qeqlCMDAKE 120
gi 169823466 177 ARDGCMPVMRTYGFGWPERMNCDLLPeg-------neCVSRSN 212
gi 86563956  104 ARSKCSPIMAKYGFRWPETLSCEALPkmsdqmstgniCAAPPD 146
gi 83318899  117 AKAGCAPLMRQYGFAWPDRMQCENLPefgd---pdnlCMDSNH 156
gi 219448493 109 ARDGCAPIMRQYQFAWPDKFECDDLPeqgd---pdrlCMHFLN 148
gi 156389432 108 ARTGCAPLMRKYGFSWPERMKCENFPelgd---entlCMGRNS 147
gi 62122563  115 SKDGCTPIMRNYGFSWPSQMSCDQFPegst---dkqlCMERDI 154
gi 47212559   97 AKQGCSPLMSQYGFEWPERMSCEKLPqlgd----evlCMDQNG 135

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