Conserved Protein Domain Family
CRD_FZ1_like

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cd07458: CRD_FZ1_like 
Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 1 (Fz1), frizzled 2 (Fz2), and frizzled 7 (Fz7) receptors, and similar proteins. This domain is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143567
View PSSM: cd07458
Aligned: 15 rows
Threshold Bit Score: 226.909
Threshold Setting Gi: 118343942
Created: 24-Apr-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # ### ###                                                              
gi 17433059   49 GYCQPISIPLCTDIaYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKFFLCSIYAPVCTVLEqALPPCRSLCDr 128
gi 170592611  38 DKCVPITMQMCRDIpYNMTLFPNILGHTKEEDASLEIHQFLPLVKVKCSEDLKFFLCTIYAPVCTVLErPIPPCRHLCLs 117
gi 194578931  31 GFCQPISIPLCTDIaYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKFFLCSMYAPVCTVLEqALPPCRSLCEr 110
gi 241998672  55 GRCEPISIPLCKDIqYNETIMPNLLNHQKQEDAGMEVHQFFPLVKVKCSPDLQFFLCSMYAPVCTILEyPIPPCRSLCMs 134
gi 219472983  43 GRCEAITIPLCTDIqYNETIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPDLKFFLCAMYAPVCTVLEeAIPPCRSLCNs 122
gi 72004782   42 GRCEAITIPLCEDMpYNMTIMPNLLNHQHQEDAGLEVHQFYPLVKVQCSEDLKNFLCSMYAPVCTVLDsALPPCKSLCLs 121
gi 156615346  27 KRCEPVTIPLCTGLqYNMTIFPNTLKHRTQEEAALEVHQFFPLVKVDCSKDLAFFLCSVYAPVCTVLEtPLPPCRSLCLt 106
gi 74956595   35 RKCEHITIPMCKNLdYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEkPIQPCRELCLs 114
gi 91082311   32 DKCKPITVPFCIDVpYNSTIFPNLVGHNTQEDAGYEVHQYFPLIKINCSADLHLFLCSVFVPVCTILEkPVPPCRSLCLs 111
gi 219410241 528 SSCEPLTVPLCQNMmYNETVFPNILGHTKQDEASLEVHQYYPLVKMGCSDVLEEFLCFVYTPPCTILEsPIPPCRSLCEs 607
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                             
gi 17433059  129 aRQGCEALMNKFGFqWPESLRCEKFPIng--------------agELCVGQNT 167
gi 170592611 118 aKNGCENLMNKFGFkWPPLLACERFPVd-----------------GMCVGENK 153
gi 194578931 111 aRQGCEALMNKFGFqWPESLACESFPVhg---------------gELCVGQNT 148
gi 241998672 135 aRSGCESLMNKFGFkWPESLECDKFPEvg--------------seKLCVGENV 173
gi 219472983 123 aRTGCEALMNKFGFqWPESLECSKFPVqgt-------------pgKICVGENR 162
gi 72004782  122 aRNGCESLMNKFGFsWPASLSCDQFPEg-----------------GLCFDRNR 157
gi 156615346 107 vRSGCEGLMKRFGFtWPDSLSCERFPKlg---------------dEICVGENT 144
gi 74956595  115 aKNGCESLMKKFGFqWPDQLDCNKFPVt-----------------DLCVGKNS 150
gi 91082311  112 aKSGCEGIMRKFGYnWPENLDCNQYPEn----------------sNLCVEKHN 148
gi 219410241 608 aRGSCEGLMMKFGFpWPENLDCSKFPEenqgppwenepgslgldrSLCLKAPE 660

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