Conserved Protein Domain Family
CRD_TK_ROR_like

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cd07459: CRD_TK_ROR_like 
Cysteine-rich domain of tyrosine kinase-like orphan receptors
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor (Ror) proteins, a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands. In addition, a number of Wnt-independent functions have been proposed for both Ror1 and Ror2.
Statistics
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PSSM-Id: 143568
View PSSM: cd07459
Aligned: 26 rows
Threshold Bit Score: 116.725
Threshold Setting Gi: 17136878
Created: 24-Apr-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # ##          ###                                                     
gi 118572711  168 GFCQPYRG-IACARf---iGNRTVYMESLHMQGei--eNQITAAFTMIGts--shLSDKCSQFAIPSLCHYAFPYCDets 239
gi 198423794  183 GRCEQYTG-FACSRf---lQGQYVYLEFFQKQEnv--eQVVSTALQFLAnl--kdVSPSCSTYAPAAFCYYFFSPCKknd 254
gi 71980965   177 GDCVQYRG-EACRQy---lSNKFVMMTNESREEmydidRNLRAAMLFINga--ptISQKCRQLSQAVACHHMYKVCEsds 250
gi 198438029  185 GKCEKYTG-VACAEf---lNGVDIYVEAFVPQSlm--eSQITTALTQISdt--rhVSEKCQKFAVPAFCYFVFRPCHhna 256
gi 170590546   59 GDCIVYRG-EACREy---lTGRHVMIVXDNREDmydvdRNLRAAMMFINss--pvISAQCKHYSHAVACYHMYKICDrgp 132
gi 238663154   10 GFCQEFHS-NVCGKy---lMGHRVYVTREFQQAli--eTQISKFLKLTAtqslhrVREDCLRRLMEAICYYNFPVCLetk 83
gi 221115866  192 SVCRSYTG-SVCSTh---lDPTKMYIYSEDNNEts-leDHLRAPIQKISt----tISKKCQSIALQAICYRIYPQCTdqd 262
gi 121582132  223 GQCVSYKE-GICASylnqgKTFVAFESNDQSIEsl--nERLKSLIMKLRqk--slISKKCEEYSLAVICYNMFSQCHnat 297
gi 50400861   315 GYCAQYRG-EVCDAvl-akDALVFFNTSYRDPEd----AQELLIHTAWNel--kaVSPLCRPAAEALLCNHLFQECSpgv 386
gi 221102135  167 HQCVSKLNsSVCAA-----FFDSKKFFYKDDTTdd-klVMLSKIAEYESfs--sfFSQRCRSHAMAFLCFYNLPYCQnsl 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118572711  240 sv---------------------pkprDLCRDECEILENvLCQTEYIFARSNpmil------mrlkLPNCEDLPqpesp- 291
gi 198423794  255 lgdvi---------------madpqplRLCQEDCDLLKHkTCKNEFFNQNADkfsp------rvfeTSDCSSLPrttp-- 311
gi 71980965   251 n----------------------nqivSICKHDCDVIQNdECPSELALAAQHelvgd----tpkalFPLCSRLSst---- 300
gi 198438029  257 tgd-------------------lvkgdGLCQEDCNTLKHdICHEEYVQRAQHpfmk------qlfdTAKCSILKssq--- 308
gi 170590546  133 gtdyra-------------tsgmpnilTICRKDCDALQAdLCPKELALAAEHdlvgd----dpkalLPKCQSLNpka--- 192
gi 238663154   84 pvsfendvssetqslnensmrylyqtrHLCRQECENVMQnECGPTYDYLDRKilyd------lpemIMDCSRLPiysmd- 156
gi 221115866  263 n----------------------pipiKICENECSKISNgKCVAEFTATNMLsyl--------qriIPNCQEPSdesees 312
gi 121582132  298 k-----------------------pvpTLCKQDCNSFKKfHCKRELEIIAEEaafi-------slyLPDCDTLPekn--- 344
gi 50400861   387 v----------------------ptpmPICREYCLAVKElFCAKEWQAMEGKahrglyrsgmhllpVPECSKLPsmhr-- 442
gi 221102135  239 ds--------------------kpkkmDVCQQDCIKLSTeYCKSEFLQAKDDrflr-------lliPDHCSTLSkd---- 287
                         170
                  ....*....|..
Feature 1                     
gi 118572711  292 -eaanCIRIGIP 302
gi 198423794  312 -tndhCTTIGLP 322
gi 71980965   301 ---snCIPVMST 309
gi 198438029  309 --sseCTSVGLP 318
gi 170590546  193 ---eyCIPIISV 201
gi 238663154  157 -npqtCRRIGEP 167
gi 221115866  313 setsdCIKLSEE 324
gi 121582132  345 ---pyCIQAYFT 353
gi 50400861   443 -dptaCTRLPYL 453
gi 221102135  288 ----nCIQFRIN 295

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