Conserved Protein Domain Family
CRD_FZ9

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cd07463: CRD_FZ9 
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 9 (Fz9) receptor, and is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. CRD containing Fzs have been found in diverse species from amoebas to mammals. 10 different frizzled proteins are found in vertebrata. Fz9 may play a signaling role in lymphoid development and maturation, particularly at points where B cells undergo self-renewal prior to further differentiation.
Statistics
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PSSM-Id: 143572
View PSSM: cd07463
Aligned: 3 rows
Threshold Bit Score: 269.971
Threshold Setting Gi: 17432964
Created: 30-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # ### ###                                                            
gi 17432964   35 GAAPCQAVEIPMCRGIGYNLTRMPNLLgHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDqvSTPIPACRPM 114
gi 220673406  34 RPAKCEPIVIPMCQGIGYNLTRMPNFMdHDNQREAAIKLNEFAPLVEYGCDVHLRFFLCSLYAPMCTDqvSTSIPACRPM 113
gi 224075631  34 RAARCQPVDIPMCRGIGYNLIRMPNMLgHESQREAALKLHEFAPLVEYGCHVHLRFFLCSLYAPMCTDqvSASIPACRPM 113
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
gi 17432964  115 CEQARLRCAPIMEQFNfgwpDSLDCARLPtrnDPHALCMEAPENATA 161
gi 220673406 114 CEQARQKCSPIMEKFNyawpESLNCSKLPtrnDPNALCMEAPENDTK 160
gi 224075631 114 CEQARHKCVPIMEQFNfgwpESLDCGRLPtknDPNALCMEAPENASA 160

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