Conserved Protein Domain Family
CRD_TK_ROR_related

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cd07469: CRD_TK_ROR_related 
Cysteine-rich domain of proteins similar to tyrosine kinase-like orphan receptors.
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor (Ror) proteins, a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands.
Statistics
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PSSM-Id: 143578
View PSSM: cd07469
Aligned: 10 rows
Threshold Bit Score: 249.245
Threshold Setting Gi: 27923847
Created: 18-Feb-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # ###        ###                                                     
gi 50400861  313 SQGYCAQYRGEVCDAVLakDALVFFNTSYRDPEd--AQELLIHTAWNEL-KAVSPLCRPAAEALLCNHLFQECSPGvv-- 387
gi 82071902  315 DLGYCSTYRGEVCQGLLgnGQLVFFNSSFADAEg--TQEMMARSTWTEL-DGVSLLCKPAAESLLCHFIFQDCNPLglg- 390
gi 27923847   66 ENGYCAPYSGKVCKEYL--TGQVWYSLEDPTGGw--KNEQVTTALWDELiSDLTGLCREAAEKMLCAYAFPNCHMEggr- 140
gi 149412999 322 DTGYCSTYKGEVCSAVLvkDALVFFNSSYADSEk--IQEMLAQAVWSEL-KTVSLLCRQAAESLLCNHVFQECHPTavi- 397
gi 45383894  313 DAGYCSTYRGEVCSAILsrNALVFFNSSYADPEe--TQELLVHTAWTEL-KTVSSFCQPAAESLLCNYIFQECKPSgvg- 388
gi 172072629 309 HAGYCSTYRGDVCRNVLrrDALVFFNYSLPNPEd--AQEYLAQSAWPEL-DGVSSFCRPAARSLLCHSTFQDCNPSglg- 384
gi 193598909  89 PSGYCAQYNGKICRKYLnaSILIWFNNTLTNEGs-eQNEIITTGLWEEMlPSFSKTCRPAAEKLLCLYAFPHCNQDt--- 164
gi 67968236  354 GAGYCGRYTGNICRGQLsnPASVWYNISSNDQTggwLNEQLVHGLWEEVvNTLREPCKSAAKKLLCLYAFPECHLDedgf 433
gi 242021869  33 SAGYCALYRGEICKDYLvgSGYVWFNKSHDGGW---LNEQITTNLWKEIiVSLKEPCLSAAKKLLCAYAFPQCSLQdnn- 108
gi 110761061  23 SQGYCAPYNGKICKKYLtgIGKVWFNDSNDNPGg-wLNERITTNLWEELiQRLVEPCRSAAEKMLCMYAFPQCHNSv--- 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 50400861  388 ptPMPICREYCLAVKELFCAKEWQAMEGKahrglyrsgmhllPVPECSKLPSMHRdp----------------taCTRLP 451
gi 82071902  391 ptPKLVCREHCLAVKELYCYKEWITMEDNsrigv---ysaglSLPDCQRLPSIHHdp----------------eaCTRVS 451
gi 27923847  141 avKAPLCFEDCQATHLQFCYNDWVLIEEKkernmfiksrghfRLPNCSSLPHYNAsmr--------------rpnCSYIG 206
gi 149412999 398 ptPKPICREHCLAVRDQYCSNDWLTMEAKshkglyqsglhqlILPECSKLPSMHVdp----------------taCTKIP 461
gi 45383894  389 paPKPICRENCLAVKDLYCFKEWLSMEENsqrgiykpglmllALPECNRLPSLHQdp----------------saCTHIP 452
gi 172072629 385 paPKPVCREHCLTVKELYCYKEWRSAEERsqrg-----fqhiTLPECTSLPSQQAdp----------------ssCTAVP 443
gi 193598909 165 -sYFPLCYEDCIAVRELFCYKEWALIEANkqrgifykskghfSLPLCENLPHNSQngk---------------pvCSHAM 228
gi 67968236  434 arKLPLCYEDCMATRQLFCVDDWAQLESNkqrgfylgsrghfRLPKCEKLPRIGSrsffmssshggskygqdppsCSRGH 513
gi 242021869 109 aiGLPLCAEDCTAVKHLFCHNDWALIDYNkrrgiylkskghfTLPNCENLPSFKNakk---------------piCSHAK 173
gi 110761061  99 --GLPLCYEDCMAVRHQFCFNDWAMIEDNkqrdiyirsrghfTLPDCESLPKIIKgk----------------vtCSHIH 160

                 ....*.
Feature 1              
gi 50400861  452 YLDYKK 457
gi 82071902  452 FLDMKK 457
gi 27923847  207 LTELKE 212
gi 149412999 462 YFEYRK 467
gi 45383894  453 FFDFKK 458
gi 172072629 444 YVDIKK 449
gi 193598909 229 LTELKQ 234
gi 67968236  514 LTQLVP 519
gi 242021869 174 LTEMPK 179
gi 110761061 161 LTDMNE 166

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