1F5S,3P96,3M1Y,3N28,4EZE


Conserved Protein Domain Family
HAD_PSP

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cd07500: HAD_PSP 
Click on image for an interactive view with Cn3D
phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p
This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319803
View PSSM: cd07500
Aligned: 30 rows
Threshold Bit Score: 247.076
Threshold Setting Gi: 27381616
Created: 10-Jul-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #####                                                                       
1F5S_A        7 LILFDFDSTLVnnetIDEIAREAGVeeevkkiTKEAMEGklnfeqSLRKRVSLLkdlpieKVEKaikri-tpteGAEETI 85
gi 21673014 194 LVVFDMDSTLItsevIDELAKEAGSgelvaaiTEQAMRGeldfteSLKKRVGTLagleesTLQKvaerl-qlteGAEHLF 272
gi 5834302  116 RGSSDMDSTAIadecMDELADYAGFrkeseeiTIRAMRGelnfdeSLKARTKLLaglktsVIQEcvrdrihltpGIKTLI 195
gi 32475161 273 IVALDMDSTLLqaevIDELAKEAGAgekvsaiTEAAMRGeidfdeSLRQRVQSLeglpesVLPKvaerl-qlteGAERLL 351
gi 15600153 217 LAVFDMDSTLIeaevIDELAKAAGVgekvaaiTERAMRGeldfraSFKERLALLqglsedVLEEigasl-rlteGAETLF 295
gi 29346242 197 LICFDMDSTLIetevIDELAIRAGVgdevkaiTESAMRGeidfteSFTRRVALLkgldesVMQEiaesl-piteGVDRLM 275
gi 15676873  72 LIVSDMDSTLItiecVDEIAAGVGLknkvaeiTERSMRGeldfeqSLRSRVALLaglderVLADvyenvlklspGAEFLL 151
gi 15889327  82 LLIADMDSTMIgqecIDELAAEVGLkdkvsaiTARAMNGeiafepALRERVALLkglpvsVIDDviekritltsGGKELI 161
gi 83591805  86 LLIADMDSTMVigetLDDLAAHAGLkdkiaaiTARAMNGeidfeaALRERVGMLaglsasALEEtwaat-altpGGRTLV 164
gi 16126336  83 LLIADMDSTIInvecLDELADFAGVkaqvseiTERAMRGelafegALRERVGMLkglgvsALQAcydervrlnpGAETLV 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ###                                          #                     
1F5S_A       86 KELknrGYVVAVVSGGFdIAVNKIKEKLglDYAFANRLivkdgklTGDVEGevlkenaKGEILEKIAkieginledTVAV 165
gi 21673014 273 YNLhrlGFKTAILSGGFtYFGRYLQKKLniDYVFANELeivdgkmTGNVIGqvvdgkrKAELLEQIAatenirleqTVAV 352
gi 5834302  196 QTMnanGAHCFLVSGGFlDFAVPVAKEIgfEKPFANTLevegdtlTGRVLDpilgpetKKEILQEECqrfgikleeTITL 275
gi 32475161 352 SNLrrfGYTTAILSGGFtYFGEHLQKLLgiDHVHANQLeivdgklTGRVLGpivnaerKALLLEQLAanegvdrkqMIAI 431
gi 15600153 296 AELkrlGYKTAILSGGFtYFARQLQAKLgiDYVFANELqivdgkvTGVAVEpivdaqrKADLLRELAakeglsleqTIAV 375
gi 29346242 276 YVLkkyGYKIAILSGGFtYFGQYLQKKYgiDYVYANELeivdgklTGRYLGdvvdgkrKAELLRLIAqvekvdiaqTIAV 355
gi 15676873 152 DECkrhDVKFLLVSGGFtFFTERLQQRLgfEYQHANVLeiengrlTGRLKGriidaqaKADLLREYRsrlglqphqVLAV 231
gi 15889327 162 ATMkakGYYTALVSGGFtVFTNRVAAMLgfDENRANLLgeangelDGTVAEpilgkqaKVDALNDIAarlgisseeAMAV 241
gi 83591805 165 RTMaanGARCVLVSGGFsVFTAKVAKACgfHDHVANRLeiidgalSGKVIDpvvdravKLATLKAEAaklglplsaCAAV 244
gi 16126336 163 RTMakhGARCALVSGGFtFFTSRVAEAAgfHLNRANTLieldgalTGAVGDpilgkeaKLAALREETaalgltpadALAV 242
                       170       180
                ....*....|....*....|.
Feature 1       ##  ##               
1F5S_A      166 GDGANDISMFKKaGLKIAFCA 186
gi 21673014 353 GDGANDLPMLGKaGLGIAFRA 373
gi 5834302  276 GDGANDIPMIEAaGLGVAYHA 296
gi 32475161 432 GDGANDLPMLSRaGLGIAFHA 452
gi 15600153 376 GDGANDLPMLGLaGLGVAFRA 396
gi 29346242 356 GDGANDLPMLGIaGLGIAFHA 376
gi 15676873 232 GDGANDIPMLKEaGIGVAYRA 252
gi 15889327 242 GDGANDLGMLHVaGAGVALHA 262
gi 83591805 245 GDGANDLPMVMAaGLGVAFHA 265
gi 16126336 243 GDGANDLAMIEAaGLGVAYRA 263

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