2FPU,2GMW,2O2X,3L8H,2FPR,2FPU


Conserved Protein Domain Family
HAD_HisB-N

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cd07503: HAD_HisB-N 
Click on image for an interactive view with Cn3D
histidinol phosphate phosphatase and related phosphatases
This family includes the N-terminal domain of the Escherichia coli bifunctional enzyme histidinol-phosphate phosphatase/imidazole-glycerol-phosphate dehydratase, HisB. The N-terminal histidinol-phosphate phosphatase domain catalyzes the dephosphorylation of histidinol phosphate, the eight step of L-histidine biosynthesis. This family also includes Escherichia coli GmhB phosphatase which is highly specific for D-glycero-D-manno-heptose-1,7-bisphosphate, it removes the C(7)phosphate and not the C(1)phosphate, and this is the third essential step of lipopolysaccharide heptose biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319806
View PSSM: cd07503
Aligned: 54 rows
Threshold Bit Score: 165.398
Threshold Setting Gi: 300786149
Created: 29-Feb-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #####                                         ####                         
2FPU_B        15 KYLFIDRDGTLIseppsdfqvdrfdkLAFEPGVIPQLLKLqk-aGYKLVMITNQDGLGTqsfpQADFDGPHNLMmqifts 93
3L8H_A         2 KLIILDRDGVVNqdsdaf--vkspdeWIALPGSLQAIARLtq-aDWTVVLATNQSGLARglfdTATLNAIHDKXhralaq 78
gi 21617817    3 PIVFIDRDGTLIeeppdfq-idayekLRLVNGVIPALLKLrd-aGYHFVIVTNQDGLGSpaypQASFDGPNALMlqifss 80
gi 21617818    4 KILFIDRDGTLIeepksdfqidtlekLRFEKDAIPTLLKLkk-fGFKFVMVSNQDGLGTpsfpKENFEIAHEKMldilks 82
gi 44888060    4 KILFIDRDGTLVieppidyqldslekLEFYPRVFRNLGFIrsklDFEFVMVTNQDGLGTssfpEDTFWPAHNLMlktlag 83
gi 159028562  37 KALFLDRDGVVIdyipyl---skpeqVSIPAGAAAALKQWqd-aGYLLIIITNQSGLARgyftWDDLAAIHGRMieeyrq 112
gi 44888038    4 KILFIDRDGTLIhepkdnfqidsldkLLLEPYVIPTLIALkn-iKFKFIIVTNQNGLGTdlfpKTKFNKPHQFMiqifks 82
gi 59797664    3 KILFIDRDGTLVeepfdfq-vdsldkIKLTSGVIPALLQLqk-aGFTFIMVSNQNGIGTvafpEEDFAVCHEFIldlfss 80
gi 52782839    2 KTLFIDRDGTINkdcpyc---hnpsdLFIYPDAVDLLQRYqd-dGFRIIIVTNQSGIGRgyftESQFKEFSDFMndklke 77
gi 206889227 324 KAVFFDRDGTLCkdany-----lskwEDFEVFPFIETLKElknlGFLLIGISNQSGIARgiirEDFVKEVNQFFidk--- 395
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                              #                       ###  ##              
2FPU_B        94 qgvqfDEVLICPhlpadecdCRKPKVKLVERYlaeqamdranSYVIGDR-ATDIQLAENmgiNGLRY 159
3L8H_A        79 xggvvDAIFXCPhgpddgcaCRKPLPGXYRDIarrydvdlagVPAVGDS-LRDLQAAAQagcAPWLV 144
gi 21617817   81 qgivfRDVLIDRswptdnapTRKPGIGLMVAYlqdrdidwarSAMVGDR-PTDLQFAENlniRGFQL 146
gi 21617818   83 cgiefQDIFICPhfenencaCRKPKTAMLEEYikhelydkeqSFVIGDR-ESDMILASNlgvRGLKY 148
gi 44888060   84 egitfDDILIDRsfpednapTRKPRTGMLTKYidnpeydlaeSFVIGDR-PTDVELAKNlgcRAIYL 149
gi 159028562 113 lgvhfHDLAICPhhpdegcpCRKPSPYLLLTAaqqygidlagSLFIGDA-PSDLECALEagcQPVLL 178
gi 44888038   83 qgikfDQILICPhlpedqcnCRKPKTGLISCWlknksldmpnSYVIGDR-DTDIQFAHNigiQGIKY 148
gi 59797664   81 qgilfDEIFICPhtpednciCRKPKTGLLESYlketafakqySWVIGDR-DTDKEFADNlgvNFLPI 146
gi 52782839   78 ngiviSAIYYCPhkpedscnCRKPETGLFSEVledykvdipsSIVVGDRnEIDGEFARRi-kLPFRL 143
gi 206889227 396 --ygfDDFFYCPhhpdercfCRKPNPGMPLIArykygidfrnSYVVGDK-DIDMQLAQMigaKGILI 459

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