2OYC,2C4N,3QGM,1PW5,2CFT


Conserved Protein Domain Family
HAD_Pase_UmpH-like

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cd07508: HAD_Pase_UmpH-like 
Click on image for an interactive view with Cn3D
haloacid dehalogenase-like superfamily phosphatases, UmpH/NagD family
Phosphatases in this UmpH/NagD family include Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase , Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase, human PGP phosphoglycolate phosphatase, Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase, Bacillus AraL a putative sugar phosphatase, and Plasmodium falciparum para nitrophenyl phosphate phosphatase PNPase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319811
View PSSM: cd07508
Aligned: 10 rows
Threshold Bit Score: 303.902
Threshold Setting Gi: 46015261
Created: 12-Mar-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                            ####                                       
2OYC_A        23 GVLFDCDGVLWnge-ravPGAPELLERLaraGKAALFVSNNS---RRARPELALRFArlgfgglraEQLFSSAlCAARLL 98
2C4N_A         5 NVICDIDGVLMhdn-vavPGAAEFLHGImdkGLPLVLLTNYPsqtGQDLANRFATAGvdv----pdSVFYTSAmATADFL 79
3QGM_A        10 GYIIDIDGVIGksv-tpiPEGVEGVKKLkelGKKIIFVSNNStrsRRILLERLRSFGlev----geDEILVATyATARFI 84
1PW5_A         7 LFILDXDGTFYldd-sllPGSLEFLETLkekNKRFVFFTNNSslgAQDYVRKLRNXGvdv----pdDAVVTSGeITAEHX 81
gi 24656326   26 SVILDADGVLWhfs-kaiDGAVDTFNYMnttGRKIFIISNNSeisRQEMADKAKGFGiei----keDNVLTSSfSCANFL 100
gi 18859765   24 RVVSDIDGVLWtfe-qsiPRAADGYAALeqmGKHLTFLTNNSvrtSEQCVKLFAKIGmqv----hpEQIWHPAkSIVSYL 98
gi 114052999  25 HVLSDCDGVIWtqd--slPRVGEFFKQMkkrGKTVNFVSNNSlrsRANYEAQFKAASidn----gfESLIIPSiAVAEYL 98
gi 221329670  24 LVISDCDGVVWllv-gwiPNTGAAVNALkaaGKQIKFVSNNSfrsEEDYMEKFRHIGakn---vqeDDIVHPVkTIVRYL 99
gi 442616048  24 LVFCDCDGVVWyplrdfiPGSAEALAHLahlGKDVTFVTNNSissVKEHIEKFEKQGhlk---ideHQIVHPAqTICDHL 100
2CFT_A        23 GVLFDCDGVLWnge-ravPGAPELLERLaraGKAALFVSNNS---RRARPELALRFArlgfgglraEQLFSSAlCAARLL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2OYC_A        99 RqrlpgppdapgaVFVLGGEGLRAELRaaglrlagdps-----------agdgaaprvrAVLVGydehfsfakLREACah 167
2C4N_A        80 Rrqe------gkkAYVVGEGALIHELYkagfti--------------------tdvnpdFVIVGetrsynwdmMHKAAyf 133
3QGM_A        85 Arekp-----nakVFTTGEEGLIEELRlagleiv-------------------dydeaeYLVVGsnrkinfelXTKALra 140
1PW5_A        82 Lkrfg-----rcrIFLLGTPQLKKVFEayghvi--------------------deenpdFVVLGfdktltyerLKKACil 136
gi 24656326  101 Avknf-----qkkVFVMGEKGVHFELEkfgicslkmseklekp-mhefvteleldpdvgAVIVGrdegfnmakLVRTGsy 174
gi 18859765   99 Qsikf-----eglIYIIASQSFKTVLReagfqlldgpnefieesyaslaehifgkepvrAVIIDvdfnltspkILRAHly 173
gi 114052999  99 Ksvtf-----nktVYCVTCTETKRVLEahgfkckegpdlgpey-ygeyiqyleddeeigAVVFDsdfkinlpkMYRAIty 172
gi 221329670 100 Kkhkp-----gerVYSLMSLEANETLRkhniefeslqvkehlt-aaslvdhlaiekpvgAVLFDihldlsyveLAKAIrh 173
gi 442616048 101 Rsikf-----eglIYCLATSPFKEILVnagfrlaqengsgiitrlkdlheaifsgesvdAVIIDvdfnlsaakLMRAHfq 175
2CFT_A        99 RqrlpgppdapgaVFVLGGEGLRAELRaaglrlagdps-----------agdgaaprvrAVLVGydehfsfakLREACah 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                  #                        ###  #
2OYC_A       168 lr-dpeCLLVATDRDPWHplsdgsrTPGTGSLAAAVETAsgrq-alvvGKPSPYXFECITenfs-idpARTLXVGDRlET 244
2C4N_A       134 v--angARFIATNPDTHGrg----fYPACGALCAGIEKIsgrk-pfyvGKPSPWIIRAALnkmq-ahsEETVIVGDNlRT 205
3QGM_A       141 c--lrgIRYIATNPDRIFpae-dgpIPGTGXIIGALYWXtgrepdvvvGKPSEVIXREALdilg-ldaKDVAVVGDQiDV 216
1PW5_A       137 l--rkgKFYIATHPDINCpsk-egpVPDAGSIXAAIEAStgrkpdliaGKPNPLVVDVISekfg-vpkERXAXVGDRlYT 212
gi 24656326  175 ll-npdVIFLGTCLDAAYpignnrvMVGAGATLAAMKAYtgrs-plvlGKPNPWMASTLMqsga-ikpETTLMVGDTlQT 251
gi 18859765  174 lr-hpeCMLIEGATDRLLpvakevnIVGPGAFASILVEAsgkq-pitlGKPGRELGDLLVehyqivqpSRVLMIGDMlAQ 251
gi 114052999 173 lk-rpeVLFINGATDRMVpmktgllGLGTGVFTDLVTVEvkre-pvllGKPGRVFGEFAMkragitdpSRVLFIGDMiAQ 250
gi 221329670 174 lqenddCQLIAGGSDVIMplaenlnVAGFFDFLEHVKRYtqre-atflGKPSPILGEMFGemfeirdcKRCIFIGDTlVQ 252
gi 442616048 176 lq-npkCLFLAGAADALIpfg-kgeIIGPGAFIDVVTQAvgrq-pitlGKPGEDLRKLLLerhreippSRVLFVGDSlAS 252
2CFT_A       168 lr-dpeCLLVATDRDPWHplsdgsrTPGTGSLAAAVETAsgrq-alvvGKPSPYMFECITenfs-idpARTLMVGDRlET 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                 
2OYC_A       245 DILFGHRcGXTTVLTLTGVSRLEeaqayla---agqhdlvPHYYVESIAD 291
2C4N_A       206 DILAGFQaGLETILVLSGVSSLDdids---------mpfrPSWIYPSVAE 246
3QGM_A       217 DVAAGKAiGAETVLVLTGVTTREnldqxi-----erhglkPDYVFNSLKD 261
1PW5_A       213 DVKLGKNaGIVSILVLTGETTPEdler---------aetkPDFVFKNLGE 253
gi 24656326  252 DMHFASNcGFQSLMVGSGVNTPKevqqiieegdpkkkilvPDTYLPSLGH 301
gi 18859765  252 DVSFGRQcGFQTLLVLSGGCSKEellaet------dpqriPDYYADSVAD 295
gi 114052999 251 DVSLGKAvGFNTLLVLTNTTKEEmlsh----------tirPDYYAASLGS 290
gi 221329670 253 DVQFGKAcGFQSLLVLSGCLTKEdmlna-------pveaqPDYYADSLAD 295
gi 442616048 253 DIGFARAsGYQTLLVLTGGTKLEdvqrlp-----idhsqmPDYLADCLGQ 297
2CFT_A       245 DILFGHRcGMTTVLTLTGVSRLEeaqayla---agqhdlvPHYYVESIAD 291

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