1KYT,1WR8,1WR8


Conserved Protein Domain Family
HAD_Pase

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cd07514: HAD_Pase 
Click on image for an interactive view with Cn3D
phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), and Pyrococcus horikoshii PH1421, a magnesium-dependent phosphatase; belongs to the haloacid dehalogenase-like superfamily
Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PGPase) catalyzes the magnesium-dependent dephosphorylation of phosphoglycolate. This family also includes Pyrococcus horikoshii OT3 PH1421, a magnesium-dependent phosphatase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319816
View PSSM: cd07514
Aligned: 27 rows
Threshold Bit Score: 119.231
Threshold Setting Gi: 46396123
Created: 28-Feb-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                               ###                                     
1KYT_A         7 LAAIDVDGNLTDrdrl--istKAIESIRSAekkGLTVSLLSGNviPVVYALKIFLgINGPVFGENGGixfdndgsikkff 84
gi 46396279    4 LVLVDLDGTLTEdrestridlDAIYAIRLLqksGIKVSLVSGNsyPILRGLYTYLyLDGGFVAENGCivfykekyrmcrq 83
gi 172046957   4 LLLTDLDGTLTEdrgtyvvdiGAIKALRRAekaGIRVALVSGNsyPVLRGLHNYLgLSGGLVAENGCfvfhggvtfrvce 83
gi 76363294    4 LILTDVDGTLTFdrdtynidlDAVDLLRKVekkGIKVGLVSGNsyPVLRALYTYFgFNGGIVAENGCivyydnqlkevce 83
gi 121722826   4 GVITDIDGTLTDekrr--lstAAIETIRKLqegGIEVVLSSGNtsCLLKGLCKLIgTGGTFIGENGGvyrigfqgsmqvm 81
gi 67460673   19 LVVLDVDGTLTDksrm--isvNAVNAIRNL---KTKVALVSGNvlPVLYGLKIYIgFDGYIFAENGGialinnniekffe 93
gi 46396653    4 LVAIDVDGTLTDkdrl--istRAIEFIRKAekkGIIVSLLSGNviPVVYALKVFIgINGPVFGENGGvmfdndgsitkff 81
gi 46396657    4 LAAIDVDGTLTDrdrl--istKAIESIRSAekkGLTVSLLSGNviPVVYALKIFLgINGPVFGENGGimfdndgsikkff 81
gi 46396121    4 LVITDIDGTITGddra--vhlKCIRYLRELqkrGIPVGIATGNtlCYSRSAATLLgFEGPLIAENGGivavddeeistvp 81
gi 166219347   4 LAAFDIDGTLTInrsstvlclEAIDALRKLeknGVIVVLVSSNalPVVVGLKKYIgLSGPAIGETGAliyygeeeivatt 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
1KYT_A        85 snegtnkfleexskrtsxrsiltnrwr----------eastgfdidpedvdyvrkeaesrgfvifysgyswhlxnrgEDK 154
gi 46396279   84 meqslvdefkslfklrdtwqneyre--------------cdfgfvpakitdeminwakernlyikssgyavhiaynpAGK 149
gi 172046957  84 tvprevvsefaktfnlreswqnefrr-------------sdfgftpaelkdemikwaeerglvvqssgyalhlsgkpGGK 150
gi 76363294   84 rverslisefenrfgvkgswqnqfkv-------------cdfsfyppilkdemvkwaldkglyiktsgyavhiskskRGK 150
gi 121722826  82 anrdiavkalnlleeyygkkgirlelysh------qerysdiafarevpveevrsllsgwpvdimdtnfaihiheagIDK 155
gi 67460673   94 kdgpesflndisgytsargiltnrwre-----------tsmaftanhdemdiidreaasrdlyivdsgftlhilnkgQDK 162
gi 46396653   82 snektnsfldemskktsmrsiftnkwr----------eastgfdidgkdvdyvkaeaekrglvvfysgyswhlmnkgEDK 151
gi 46396657   82 snegtnkfleemskrtsmrsiltnrwr----------eastgfdidpedvdyvrkeaesrgfvifysgyswhlmnrgEDK 151
gi 46396121   82 eedieliqeayrelrrrlgvrrteppglrr-----tevaiyrdvpieevervldglgysgrievvdtgfayhlkskrVDK 156
gi 166219347  84 kysakqayldvlekyneyvygswqnmfrlhdyalkirkqylskdneiyslikeyvenkypyikvgysgyaihltpkdTGK 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                             ### ##                                            
1KYT_A       155 AFAVNKLKexysleydeILVIGDSNNDXPXFQLPVRKACPANAtDNIKAVSDFVSDYSYGeeiGQIFKHFE 225
gi 46396279  150 RIGVEKLLqllglkkedVAAIGDSSTDIELFQQVGFKVAVGNAdDELKDIADYITSNKSGkgvREFVDKLL 220
gi 172046957 151 GAGVRKLLelanvkreeTGAIGDSRTDIEMFREAGITAAVSNAdPELKRVASISLKLKSGagvMEFIDMLL 221
gi 76363294  151 AEGVRELIkmhgldkaeVVGIGDSSTDIEFLEEVGIRVVVGNAdESLKSIGDFVMREKSGkavVEFIKKVI 221
gi 121722826 156 GRTFHIVAeqlgikpdeFLGIGDSENDIGMIKAAGTGCCVANAqEDVRNISDYCSSVPYGegfVEIMRMYF 226
gi 67460673  163 GFAVKKMIdimnidynnVLVIGDSQNDESMFSLGTLSACPGNAsEKIKEMSNYVSGKCYGdelFDVFRHFD 233
gi 46396653  152 GFAVKILKekyglnyeeILVVGDSNNDMPMFELPVFKACPANAtDNVKKASDFVSSYSYGeeiGEVFSHFN 222
gi 46396657  152 AFAVNKLKemysleydeILVIGDSNNDMPMFQLPVRKACPANAtDNIKAVSDFVSDYSYGeeiGQIFKHFE 222
gi 46396121  157 GKGLLVICerlgidpddVVAIGDGDNDAPLLKAAGLGVAPANAtENVKRIADVVLDAENGegvATFLRKLL 227
gi 166219347 164 GKALKQIMekhgirreeTMGVGDSIMDWEFIKETKIKVAVANAdPELRRKADIVTTKPSGygvVEIVEKIL 234

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