2PKE,3DDH


Conserved Protein Domain Family
HAD-like

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cd07515: HAD-like 
Click on image for an interactive view with Cn3D
uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily
The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319817
View PSSM: cd07515
Aligned: 8 rows
Threshold Bit Score: 168.366
Threshold Setting Gi: 149243186
Created: 8-Apr-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
2PKE_A        15 LVGFDGDDTLWKSEdyyrtaeadfeailsgyldlgdsrxqqhllaverrnlkifgygakgxtlsxietaielteariear 94
3DDH_A        10 VIAFDADDTLWSNEpffqevekqytdllkpygtskeisaalfqtexnnlqilgy--gakaftisxvetalqisngkiaad 87
gi 156235538  27 TIAFDADDTLWHNEhlysltqekfkrllapfqdaatierrlyatemrnlaffgy--gikgftlsmietaidltegrvgah 104
gi 144900986   3 LVAFDGDDTLWHNEplfwatqdrfkallepycppehlaerllatevanlglfgy--gikgfvlsmietaiqvsdgqvpnt 80
gi 29347590    7 VIAFDADDTLWSNEpffqevekqytdllkpygtskeisaalfqtemnnlqilgy--gakaftismvetalqisngkiaad 84
gi 83593640   37 VIGFDADDTLWHNEthfqemqralaaiisghtgettpiddplmaverrnlkkyg-ygakgfalsmietaleltdqrvsga 115
gi 16127049   10 TVGVDADDTLWHCEslfrlsharflellsehgdpekieaqltavekrnlrvygy--gakgftlsmietalevtdglvdtr 87
gi 77464260    7 TIAFDADDTLWQNEtfyrltqerfaallarhvekdrlherllaaerrnlgrygf--gikgfmlsmietaievteervpag 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 ##                           #         
2PKE_A        95 diqriveigratlqhPVEVIAGVREAVAAIaa--dyAVVLITKGDLFHQEQKIEQSGLsdlFPRIEVVSEKDPQTYARVL 172
3DDH_A        88 iirqivdlgksllkxPIELLPGVKETLKTLketgkyKLVVATKGDLLDQENKLERSGLspyFDHIEVXSDKTEKEYLRLL 167
gi 156235538 105 eirqiidfardmvraPVELLPGVRETIASLsa--syRLMVITKGDLFDQESKIARSGIadyFQHIEIVSEKTPETYAAVM 182
gi 144900986  81 viqeliergkhmlahPVHLLDQVAEAVAAVkag-ghRVMVITKGDLMDQEAKLARSGLadlFAAVEVVSEKDEALYRRLF 159
gi 29347590   85 iirqivdlgksllkmPIELLPGVKETLKTLketgkyKLVVATKGDLLDQENKLERSGLspyFDHIEVMSDKTEKEYLRLL 164
gi 83593640  116 eiariiamvhrfldgDIHILDGAVETLTRLrh--nhRLILITKGDEIEQQEKLAKSKLrsfFDTVYVVLEKDPDTYRSIL 193
gi 16127049   88 vireilavgremltePIEPLPGVENALSALsd--ryRLILITKGDLLHQEQKLASSGLgdyFVAVEIVSEKDADTYRRVF 165
gi 77464260   85 vigeiiaagqemlahPIELLDHAREAVEALaa--dyRVLLVTKGDLLDQERKLAQSGLgdmFHAVEIVSDKNARVYDRIF 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                     ##   ##                                    
2PKE_A       173 SefdlpaerFVXIGNSlRSDVEPVLAIGGWGIYTPYa-----vTWAHEQDHGVAAD 223
3DDH_A       168 SilqiapseLLXVGNSfKSDIQPVLSLGGYGVHIPF-------EVXWKHEVTETFA 216
gi 156235538 183 RryhiepprFLMVGNSlKSDILPVVAVGGNAVYIPYhl---twEHERVTDEGVNAG 235
gi 144900986 160 AkhgsgceaCVMVGNSvRSDILPVLAAGGWAVHIPYagpvwahERAEPPVDHPRYA 215
gi 29347590  165 SilqiapseLLMVGNSfKSDIQPVLSLGGYGVHIPFevm--wkHEVTETFAHERLK 218
gi 83593640  194 GreaidpghFVMVGNSlRSDIHPVLAIGGRAILIPYevt--wkHEMVELPADAPKA 247
gi 16127049  166 DrygtgaeqAVMAGNSmRSDVLPALDAGCWGALIPYplv-wshEAADAPLGHPRYV 220
gi 77464260  163 RrhgdgperALMVGNSlKSDVLPPIEAGGFGVHVPHglt-walEHADPPDGHPRFF 217

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