1YMQ,2PQ0,3R4C,3FZQ


Conserved Protein Domain Family
HAD_HPP

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cd07517: HAD_HPP 
Click on image for an interactive view with Cn3D
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily
Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319819
View PSSM: cd07517
Aligned: 18 rows
Threshold Bit Score: 243.284
Threshold Setting Gi: 223365936
Created: 12-Mar-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #####                              ###                                     
1YMQ_A         3 KALFFDIDGTLVsfethripsSTIEALEAAhakGLKIFIATGRpkAIINNLselq-drnLIDGYITMNGaYCFVGee--v 79
3R4C_A        13 KVLLLDVDGTLLsfethkvsqSSIDALKKVhdsGIKIVIATGRaaSDLHEIda-----vPYDGVIALNGaECVLRdg-sv 86
gi 15672719    4 KAVFFDLDGTLFtstr-gvatSTRKAIQELrqkDIFVGIATGRgpAFVMPLle----dlDLDFAVSYNGqYIFTPke--v 76
gi 15677512    4 KIVFFDIDDTLYrkytdtlrpSVKTAVAALrgkGILTALATGRslATIPEKvrdmmaeaGMDAVVTINGqFALLHgk--t 81
gi 15672874   12 KIIFFDIDDTLRvkdsafmpeSITEVFYKLrekGIMTGIATGRnlFGVVPEvr----alKPDFYVAINGaYVENAqtgev 87
gi 81822710   17 KMVFFDIDDTLRvkdtgympeSIQRVFKALkakGILVGIASGRarYGVPQEvq----dlHADYCVKLNGaYVKDDak-ti 91
gi 253755004  13 KIVFFDIDDTLRvkntgyipeSIQQVFKSLkekGILTGIASGRtpYGLVPEik----alKPDFFAMINGsYVEDAkg-qv 87
gi 29375828    6 AITFFDLDGTLLdgts-qitpEITAAVAALkdnQILPLIATGRtlCEIQPImk----asGIDSAIVMNGqFIHYEgk--t 78
gi 16804247    5 GICFFDMDGTLLnses-kvldTSLQALDKLrenNVIPVIATGRtlIEISHQmk----itGIESAVMMNGqMAIFEge--k 77
gi 49477479    3 KVVFFDVDGTLLseidrsmheSTKEAIRRLidkGIHVVVTTGRp-YSLCSQfn----alGINTIISANGaHIKCGet--v 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1YMQ_A        80 IYKSAIpqEEVKAMAAFCEKkgvPCIFVEehnisvcqpnemvkkifydf--------------------lhvnviptvsf 139
3R4C_A        87 IRKVAIpaQDFRKSMELAREfdfAVALELnegvfvnrltptveqiagiv--------------------ehpvppvvdie 146
gi 15672719   77 IFQNPLeqKSLKNLINYATEnhsDISLGTahgvngsgllkfgetrlasflsgvlpsgtsgvarnsfkhiirrvlpqnsnl 156
gi 15677512   82 VREVPMdaGLMGRVCAHLDGlgmDYAFVGgegiavsalsecvcralkhi---------------------asdffadkdy 140
gi 15672874   88 LYKNTFskELIEEIITWLKNeqsGYSFVAadslkiskwdkiasdaigp----------------------vyseleenpn 145
gi 81822710   92 IFQAPIpaDVVVAYKKWADDmgiFYGMAGrheavlsarndmisnaidn-----------------------vyaqlevcp 148
gi 253755004  88 VYHQPMpqNLVESVLNWAKEigiEYGMLSsqkgtlsartdrisqvidl-----------------------iyegletkp 144
gi 29375828   79 IYSDEFttEECVSLHEHVKQrghELAFYNerrifctghtgtvkqaydyi--------------------hsavpeidptg 138
gi 16804247   78 VYEDVIdaGLLEQLTEEAKSqnvEVCYYNdkrigatastpvvkahyd------------------------flgepmpev 133
gi 49477479   76 IHKSVLssEIVHDLSEFAALhghGVSYFTedfamngiaahngrvmqals--------------------etlnlekypek 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           #                     ##  ## 
1YMQ_A       140 eeasnkeviQMTPFit-eEEEKEVLPsi-ptCEIGRWyp-aFADVTakgdtKQKGIDEIIRhfgikleeTMSFGDGGNDI 216
3R4C_A       147 emferkeccQLCFYfd-eEAEQKVMPll-sgLSATRWhp-lFADVNvagtsKATGLSLFADyyrvkvseIMACGDGGNDI 223
gi 15672719  157 adneeeviyQAMMVat-rNETARLQEaf-peLLVTRSnp-ySVDLIsksggKLPGIQRLGEhygftldqVMCFGDSENDL 233
gi 15677512  141 fsskpvyqmLVFAEen-eMPLWSDIVer-egLKTVRWhe-eAVDLLpagasKTDGIRSVVEalgwemadVMAFGDGLNDV 217
gi 15672874  146 yyktneiyqMLTISdh-dDQLELPEIls-dkIRLVRWhp-nSSDIVpmegsKAIGCQKVLQelglkaenMMNFGDGLNDR 222
gi 81822710  149 dyneyhdvyQMWTFedkgDGLQLPAEla-ehLRLVRWhd-nSSDVVlkgtsKALGVSKVVDhlglkpenILVFGDELNDL 226
gi 253755004 145 tfykendiyQLLTFekdgHEVELPEElq-aeLRSVRWda-iSSDIVlkgssKATGVAKVVEklglkpenVLVFGDGLNDI 222
gi 29375828  139 yendavnmmLVLSQhg-dDDEYYYERfp--eLTFYRNgp-fSIDIVrkgvsKGSGVKNLFNtlglngipTYAFGDGINDL 214
gi 16804247  134 rpnmykeetINMALll-lETGDDYFPerfpeLQFVRNtp-fSNDVLrkggsKAVGISKLLEvmgyqdvpTYAFGDGMNDL 211
gi 49477479  136 srdlseeiyCLCLYad-eIEAQKFLEry-paLTFERFhgyvMNVLEdnkvsKVTAIQKVLEhlnickseAIAFGDGRNDI 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
Feature 1                                                   
1YMQ_A       217 SMLRHaAIGVAMGQAKEDVKAaADYVTAPidEDGISKAMKHFG 259
3R4C_A       224 PMLKAaGIGVAMGNASEKVQSvADFVTDTvdNSGLYKALKHFG 266
gi 15672719  234 TMISGvGYGIAMGNAVPEVKNiATYITDTnnQDGIAKALAYYG 276
gi 15677512  218 EMLSEvGFGVAMGNGEQAAKEaAKYVCPSvdEDGVLRGLQDLG 260
gi 15672874  223 ELFDFaGLSVAMKISHPEILEkADYITDSveNDGILKALQALK 265
gi 81822710  227 ELFDYaGISIAMGVSHPLLQEkADFITKKveEDGILYALEELG 269
gi 253755004 223 ELFDYaGISIAMGHSHPELQKhADYITKKveEDGIFDALEKLG 265
gi 29375828  215 ALFEAcDYGIAMGNAREELKEkATFISTKntENGIVNGLKKFD 257
gi 16804247  212 EMFGAvDYAIAMENAVPLLKEkATFVTKDnnSDGIMLGLKQFD 254
gi 49477479  214 EMLEYvGLGIAMGNGGEGLKIrADFVTKKasEGGILFALEKHY 256

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