Conserved Protein Domain Family
HAD_PTase

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cd07519: HAD_PTase 
hydrolase domain of the bifunctional HAD hydrolase/UbiA family prenyltransferase proteins and related domains; belongs to the haloacid dehalogenase-like superfamily
This family includes bifunctional enzymes that have both an N-terminal HAD hydrolase domain and a C-terminal UbiA family prenyltransferase domain. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases. Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases (PTases) and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. PTases catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.
Statistics
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PSSM-Id: 319821
View PSSM: cd07519
Aligned: 9 rows
Threshold Bit Score: 138.634
Threshold Setting Gi: 159180386
Created: 20-Mar-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
gi 187714094   5 PLVVDLDGTLIrsdiliesgfaylkaapqrfyepll-wlarggkpglkarladatnvdvavLPYDATVLQWLKVErdaGR 83
gi 22299726    3 YLLIDLDNTLLrteifleliclslselliqlftt-----rsfncaqikrklatcadldiatLPYNPEVIQYIQDWkakGG 77
gi 21109966   17 ALCVDLDGTLLnsdilyesvlallarnplyvfllp--lwllrgkaalkrelasrvvlpaetLPYNHQVLELLRTTt--QR 92
gi 86283121  117 PLVVDLDGTLVrsdllietafselsrrplsivdfv--rslsagkaclkhhlsqpedfdpaiLPYDAEVLKVIKAAreeGR 194
gi 21646077    4 PLVVDLDGTLLrsdmliesvlayskkgirpvfhlp--fwllegkailkarladrvdlsvevLPYNTEVIDFIKQAkreQR 81
gi 66045543   14 PLVVDLDGTLLrsdmlfetavafirghplklfslf--awllqgkaslkqglalgtdidvalLPFNADVIDYIQTErqtGR 91
gi 206685195   1 MLAVDLDGTLLrsnilyesfwssfgrdwksplsaa--vallngraalkrhlagtsridaasLPYDPAVVDYVSDWrqrGG 78
gi 14028445   73 PLVCDLDGTLIrsdtfhesffeaffhspqhllrtf--pswfkgraalketlanvcsiepraLPYRAEMLELMRGAkadGR 150
gi 159180386   4 PLCVDLDGTLIktdllyetllaalsrrpwivfllpvwlvsgrahlkarlleaagegvdvdlLPLTDDLVAYLQAErasGR 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1             ##                                #                ##  ##              
gi 187714094  84 SLVLATAsheRYAQAISAHLGIFDrtfatngsinLSAHNKRDTLVAeygekGFDYAGNsHDDLAVWQSAd-RAYVV 158
gi 22299726   78 KVVLIAAtdqLIAERIAAHLGLFDevygsdgqlnLKGENKARFIRErfgekNFIYMGDsEADLPVWAVAa-KAITV 152
gi 21109966   93 PRALCTAsdaLLVQPIAEHLGLFEqviasdgkrnLSGRNKAEVLVDafgqgNFDYAGNgSVDLHVWDKAg-GAWVV 167
gi 86283121  195 SVYLASAsheRLVCTVADHLGLFTgwfatnetmnCVAEVKAAKLVAafgegGFDYIGNdPADLSVWRHAakSYAIR 270
gi 21646077   82 QIVLATGthkMFAEKIAEHLGLFDlviatenginLSARSKRDCLIDqfgekGFDYIGNsHDDVVVWNAAd-KTYLA 156
gi 66045543   92 SVILATAsheTLANRIAAHLQLFDhvwasdgrtnLSAHRKRDLLVShygeqGFDYIGNsRDDLCIWGVSr-KAIVA 166
gi 206685195  79 QTALVTAsdqSIADQIAAHLDLFDevhgssgtenLKGPVKAEFLQSrfgagGFAYMGDsPADLPVWRLAs-KAVTV 153
gi 14028445  151 EIYLVTAadqSIADSIICHLGGFAgakgsdgslnLKSRNKLKWLQAsf-peGFIYAGDsAADLPIWEAAs-GAVLV 224
gi 159180386  84 RIELVSAsdqRIVDRVAARVGVFDaalgsdgrtnLKGLAKARLLIDrh-pdGFVYAGDaRADLAVWDRAv-GAIPV 157

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