Conserved Protein Domain Family
HAD_like

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cd07520: HAD_like 
uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily
The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319822
View PSSM: cd07520
Aligned: 5 rows
Threshold Bit Score: 177.255
Threshold Setting Gi: 15807208
Created: 21-Mar-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #####                                                                       
gi 15830602   5 VVLSDLDDTLFQTRRKmvdelalepfrtgavdrtLNPRSFmteeqsmlvdWLLEQAel-iPVTARGTEEISRVripfhSW 83
gi 28868156   7 LIFVDLDDTLFQTARKtpadiekh---vatldisGNANGYmtnvqksfahWLLAHAdv-vPVTARSVEAYSRVklpftAG 82
gi 83592236   4 VVFVDLDDTLFQTARKnpgaqtl-----aaldkdGKPLSFqstrqvafleWLSADAvi-vPVTGRSVEAFRRVtlplgPR 77
gi 49531075  18 LMLVDLDDTLFQTHRRivpqtdfk---mvttdkqGQALAYmnpiqqhfvqWLLHSThl-iPVTARSAEALSRVhlpfqYG 93
gi 15807208  10 LAFADLDDTLFQTLRKlpghgraal-tpatvntrGEAHSYctpaqtalldLLTAGAvtviPVTGRDPAAMRRVtlpfrSW 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##                                                                           
gi 15830602  84 AITTHGaVILTPEGKPDEEWkahmlgqlapyqekltsmqrlitemmdakginawarlnfeygem-avymvmkhrdstrld 162
gi 28868156  83 AICSHGgVMLDVMGRLDPDWneqmkqtlasyqsrlhelsaatlaigqemgfslrgwvveeaql---fhyvvtkhnesdds 159
gi 83592236  78 AICSFGgVILGADGLPHPEWhrqmsqkaqatarvmellddmvaqvlartgvdarhhiihdael----alylsikhnggsa 153
gi 49531075  94 AVCSHGgTVLNPDFSVNVDWhvqmqqaltsyqerqqilidalqqqainfgsirtwvveeqglglyivakqntendnpyap 173
gi 15807208  89 RVLDHGlTILTPAGELDSEWaaqvqahltplqgtltaltadmrahadalgcrltvhragdlpfm-tvikhpdadpealaa 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                          #                       ##  ##             
gi 15830602 163 elnaiadeietvfptegfyihrnsnnvawLPTPVEKGLAVSwlleklraergvfpVIGLGDSLSDHRFMKLCSWFGIP 240
gi 28868156 160 iltkvlaemqarglldgmhihgngnnlafLPEGLAKRYAVQewlrrdlaingerpVLGFGDSITDLGFMDECHWWATP 237
gi 83592236 154 eetarlaqalapavpegwtthlnganmalLPPFLGKRAAVAffletql-gdgpllTIGFGDSLTDLGFMSLCDYALTP 230
gi 49531075 174 nflpellnslssevlegfyfhlngnnlalIPQPVSKANAARfvlqqf--asqqrpILGFGDSLSDVEFLNLCHWWGMP 249
gi 15807208 168 lqtrweaavddtdgthplhvianannvslLPRAPGKAQAVRwlrerh--fpgavlTLGLGDSVSDLPFLRECDFAVTP 243

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