2FEA,2FEA


Conserved Protein Domain Family
HAD_Pase

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cd07524: HAD_Pase 
Click on image for an interactive view with Cn3D
phosphatase, similar to Bacillus subtilis MtnX; belongs to the haloacid dehalogenase-like superfamily
Bacillus subtilis recycles two toxic byproducts of polyamine metabolism, methylthioadenosine and methylthioribose, into methionine by a salvage pathway. The sixth reaction in this pathway is catalyzed by B. subtilis MtnX: the dephosphorylation of 2- hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HKMTP- 1-P) into 1,2-dihydroxy-3-keto-5-methylthiopentene. The hydrolysis of HK-MTP-1-P is a two-step mechanism involving the formation of a transiently phosphorylated aspartyl intermediate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319826
Aligned: 12 rows
Threshold Bit Score: 258.802
Created: 5-Jun-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #####    # ##                                   #                           
2FEA_B          8 FIICDFDGTITxnDNIINIXKTFApp----eWXALKDGVLsktlsIKEGVGRXFGLlpsslKEEITSFVLEDakIREGFR 83  Bacillus subtilis
2FEA_A          8 FIICDFDGTITxnDNIINIXKTFApp----eWXALKDGVLsktlsIKEGVGRXFGLlpsslKEEITSFVLEDakIREGFR 83  Bacillus subtilis
NP_014388       5 VIFTDFDGTVTleDSNDYLTDTLGfgk--ekRLKVFEGVLddtksFRQGFMEMLESih-tpFPECIKILEKKirLDPGFK 81  Saccharomyces ...
AAM03453        8 IVFTDFDGTITlkDSNDYLTDNIGygp--ekRREGNIDILenrvkFRDAFKEMLDSvk-kpFPECIEILRKNikLDPGFK 84  whitish truffle
CAO90042        4 IVFCDFDGTITavETFAGMLKEFApdlsaqiMPQMYARTLs----LRRGVRQLLESipsqkYADIIAYAENKp-IRPGLA 78  Microcystis ae...
jgi:Exig_0429   4 RILCDFDGTVTehDNIIALMTEFApp---eaFEPLKKGVLdqslsIQSGVGQMFRLlpsdrKQDYIDFLEQRavIRPGFK 80  Exiguobacteriu...
C0ZL41          6 VLFCDFDGTITekDNIVAIVRKFApp----eWEALTEQILsqkisVQEGVGKLFQLlpsslRQDIIDFIVHEatIRPGFA 81  Brevibacillus ...
C4KZ51          4 HVICDFDGTITeeDNIIALMRRFApp----eWVELKDSVLnqtlsIREGVGQMFSLlpsnqQERYREFLQSTitLRAGFV 79  Exiguobacteriu...
B1HYT5          4 IIFCDFDGTITetDNIFSLMTEFVpqesekiAKAMMEQTIs----FKDGLSAMFHLlsteqKDEVIQYLMDTavIREGFE 79  Lysinibacillus...
Q9P6N2          8 YVFSDFDGTITlqDSNDYLTDNFGmgn--anRVNLNQQVLdgsisFRDAFAKMLDSvh-lsYDEALEVLKKNvaIDPSFK 84  Schizosaccharo...
Q5L1E1          6 VLFCDFDGTITenDNIIAIMKQFApp----eWEALKDDILaerisVQEGVGKMFSLlpsslKGEIIDFLRRTtrLRAGFR 81  Geobacillus ka...
Q635P2          4 QVFCDFDGTITnnDNIMSIMEKFApp----eAEEVKNRILsqelsIQEGVSQLFQLiptnlHDEIIQFLIETaeIRNGFH 79  Bacillus cereu...
Feature 1                         ##                                                              
2FEA_B         84 EFVAFINehEIPFYVISGGXDFFVYPLLegi-----vekDRIYCNHASFdn---------dYIHIDWphsckg----tcs 145 Bacillus subtilis
2FEA_A         84 EFVAFINehEIPFYVISGGXDFFVYPLLegi-----vekDRIYCNHASFdn---------dYIHIDWphsckg----tcs 145 Bacillus subtilis
NP_014388      82 DTFEWAQenDVPVIVVSSGMKPIIKVLLtrlvgqesihkIDIVSNEVEIda--------hdQWKIIYkde---------- 143 Saccharomyces ...
AAM03453       85 DFYDWCLseKIPVIVLSSGMEPIIRALLtdlvg-phadqIKIVSNQPKFldpegnewtveyHDDSDF------------- 150 whitish truffle
CAO90042       79 EFLAFLQeqSIPFIIISGGIQGMIETVLkregl--ldkvTAIYGVNLHTqge-------ylQVHSDWene---------- 139 Microcystis ae...
jgi:Exig_0429  81 TLLAFAKsnGIDFAIVSGGIDFFVQPILqel-----ltdEAIYCNGSDFsg---------eTIRIEWphtcda----acn 142 Exiguobacteriu...
C0ZL41         82 EFVSYCReeGIELLITSGGIDFFLEPILapfd----ladVPIYCNGSDFsg---------eRITITWpnacde----hct 144 Brevibacillus ...
C4KZ51         80 EFLQETQshGFRFDVVSGGMDFFVHPILegh-----vapEHIFCNHVDFsget-----arvTWPHACdvhc--------l 141 Exiguobacteriu...
B1HYT5         80 DFVRYAQnhDIPFYIVSGGVDFFIEPLVeky-----gpfSGIYCNKADFsg---------eQIKLIYsnscdeecakyst 145 Lysinibacillus...
Q9P6N2         85 PFYEWCKsqDIRVIILSSGMEPFIRALFeqylgkeeassIEIVSNDINV------------HPDGQWnivyh------dd 146 Schizosaccharo...
Q5L1E1         82 EFVAFTKerGIPLYIVSGGIDFFVYPLLegl-----iepERIFCNGSDFsg---------eTIRITWphacdg----ecq 143 Geobacillus ka...
Q635P2         80 EFIQFVNenNISFYVISGGMDFFVYPLLqgl-----ipkEQIYCNETDFsn---------eYITVNWphpcdr----lcq 141 Bacillus cereu...
Feature 1               #                           ### ##                                        
2FEA_B        146 nqcGCCKPSVIHELSep----------nqYIIXIGDSVTDVEAAKLSDLCFARdYLLNECREQnlnhlpyqdFYEIRKEI 215 Bacillus subtilis
2FEA_A        146 nqcGCCKPSVIHELSep----------nqYIIXIGDSVTDVEAAKLSDLCFARdYLLNECREQnlnhlpyqdFYEIRKEI 215 Bacillus subtilis
NP_014388     144 spfGHDKSRSIDAYKkkfestlkageqrpVYFYCGDGVSDLSAAKECDLLFAKrGKDLVTYCKkqnvpfhefDTFKDILA 223 Saccharomyces ...
AAM03453      151 ---GHDKSLAIKPTGnlpk------edrpVLFYCGDGVSDLSAARETDLLFAKyGHDLITYCEregapftvfKTFEDIHR 221 whitish truffle
CAO90042      140 -teLVAKALIMDKYSg------------vETIAIGDSVTDITMARKADLVFARdRLIDYLQAEnqpyipwdnFFEIREYL 206 Microcystis ae...
jgi:Exig_0429 143 nqcGCCKTSIARKLKqd----------gdIIVTIGDSVTDFELAKQADHVYARdYLITLCEQHgiaytpfetFYDIVDHL 212 Exiguobacteriu...
C0ZL41        145 ngcGMCKTTIIRRYDpa----------thFRIVIGDSITDLAGAKIADYVIARsFLADKAEELqlphstfatFHDVIRIL 214 Brevibacillus ...
C4KZ51        142 ndcGCCKPTIARQIVsp----------tdTLIVIGDSVTDFEIAKRADVVYARgQLISLCEAEgirhvpfetFYDISAYM 211 Exiguobacteriu...
B1HYT5        146 qgcGCCKPSVMRKVAke----------ehFKIVIGDSLSDFEAAKQADIVLARdHLIQRCEELhvsykpfitFHDCLKIV 215 Lysinibacillus...
Q9P6N2        147 shfGHDKSLTIRPYAqlpe------skrpHMVYCGDGVSDLSAAKETEHLFAKkGRDLIKYCErekisfsefETFADIHK 220 Schizosaccharo...
Q5L1E1        144 ngcGCCKPSLLRKLArp----------dgYHVVIGDSITDLAVAKQADYVMARdFLLQKCQELglphapfatFFDVIDAL 213 Geobacillus ka...
Q635P2        142 nhcGLCKSSLIRKLSdt----------ndFHIVIGDSITDLQAAKQADKVFARdFLITKCEENhisytpfetFHDVQTEL 211 Bacillus cereu...
Feature 1           
2FEA_B        216 EN 217 Bacillus subtilis
2FEA_A        216 EN 217 Bacillus subtilis
NP_014388     224 SM 225 Saccharomyces cerevisiae S288c
AAM03453      222 DI 223 whitish truffle
CAO90042      207 LL 208 Microcystis aeruginosa PCC 7806
jgi:Exig_0429 213 QT 214 Exiguobacterium sibiricum 255-15
C0ZL41        215 QQ 216 Brevibacillus brevis NBRC 100599
C4KZ51        212 KG 213 Exiguobacterium sp. AT1b
B1HYT5        216 QE 217 Lysinibacillus sphaericus C3-41
Q9P6N2        221 DL 222 Schizosaccharomyces pombe 972h-
Q5L1E1        214 QR 215 Geobacillus kaustophilus HTA426
Q635P2        212 KH 213 Bacillus cereus E33L

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