2FDR,4EEK


Conserved Protein Domain Family
HAD_BPGM_like

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cd07526: HAD_BPGM_like 
Click on image for an interactive view with Cn3D
subfamily of beta-phosphoglucomutase-like family, similar to Escherichia coli 6-phosphogluconate phosphatase YieH
This subfamily includes Escherichia coli YieH/HAD3 an 6-phosphogluconate phosphatase, which can hydrolyzed purines and pyrimidines as secondary substrates. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate, and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319828
View PSSM: cd07526
Aligned: 14 rows
Threshold Bit Score: 157.095
Threshold Setting Gi: 384482575
Created: 25-Sep-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                      
2FDR_A        5 DLIIFDCDGVLVDSEIIAAQVESRLLTEAGypisveexgerfagxtwk-------nillqveseasiplsasLLDKSEKL 77
4EEK_A       29 DAVLFDLDGVLVESEGIIAQVWQSVLAERGlhldlteiamyftgqrfdgv--laylaqqhdfvpppdfldvlETRFNAAM 106
gi 27375907   4 DLIIFDCDGVLVDSEVISCRAHADVLTRHGypitseevlirflgvsekdar-rmveqeigrslpddlesqvnAATLQFYA 82
gi 27377901   7 ELIIFDSDGVLVDSEIIALTVLVRTASEEGvsismedairsfrgvkmtdcv-reierrlgrsvrdtfvadvrQATALAFD 85
gi 15595759   6 DALISDCDGVLVDSEVIAERVMYEALSAYApleelqrllegtfgltsrdi--ldrvekhfglripdsfnrevRQRSEEMV 83
gi 401623     5 EAVFFDCDGTLVDSEVICSRAYVTMFQEFGitldpeevfkrfkgvklyeiidivslehgvtlakteaehvyrAEVARLFD 84
gi 15890531   7 PLLIFDCDGVLVDSEPVSIAVLLDMLSHLGvtmgeeeayerflgrsvasmt-ttlfeeygvetdidfldhmrATLFERFR 85
gi 27378329   9 DLIIFDCDGVLVDSELLSCRCLSEVLAEFGlalseeqalelflgrstrai--eqhyrdlgqvvpdgflprlkSRVLETFS 86
gi 77463661   4 GLVIFDCDGVLVDSEVLAVAVLIAELDRAGarvdeafvhrhflgrsfpvvq-evvqrqfgvtlpetfqagerARLLAAFE 82
gi 21232151   4 ELLISDCDGVLVDSEILADRVMREALAAFVpaeplehllettfgqttrevl-rrveehfalqlpetllaqiqARSEALIA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       ##                                  #           
2FDR_A       78 LDXRLErdvkiiDGVKFALSRL---TTPRCICSNSssHRLDXXLTKvglkpyfAPHIYSAKDlgadrvKPKPDIFLHGAA 154
4EEK_A      107 TGVTAI------EGAAETLRALraaGVPFAIGSNSerGRLHLKLRVagltelaGEHIYDPSWvgg-rgKPHPDLYTFAAQ 179
gi 27375907  83 SDLQPI------THVAAAIAAI---DLPKCVASSGtpEKIHHGLTCaglydllAPNIFSASQva--rgKPAPDLFLFAAA 151
gi 27377901  86 AELRPV------EGIHAALAAI---TAPVCVASNGpmSKLTHALGLtsllghfEGRIFSAYEvg--swKPDPGLFLHAAQ 154
gi 15595759  84 AQVQPI------PGAREALLAL---DLPVAVASNSrrHSLERSLARaglseliGERLASADMva--lpKPAPDVYLHAAS 152
gi 401623    85 SELEAI------EGAGALLSAI---TAPMCVVSNGpnNKMQHSMGKlnmlhyfPDKLFSGYDiq--rwKPDPALMFHAAK 153
gi 15890531  86 TELKPI------DGIAETLDELl--PLKRCVASSSqpERIRYSLGLtglidkfEPHVFSATMvr--ngKPAPDLFLHAAR 155
gi 27378329  87 ASLEPI------PGVGAVISGL---AAPFCVASSSdiDRVSLSLDVtglrahfGARLYTAQMvr--hgKPAPDLFLHAAA 155
gi 77463661  83 TGLRAM------PGAAETVRAL---AVPFCLATSStpARLTRSLEItglaalfEGRCFTASQva--rgKPAPDLFLLAAA 151
gi 21232151  83 AEVQPI------AGVRQALEQI---PLPLAVASNSrrHNVIASVERagltaraAGRIFSADMve--rpKPAPDVYLLAAR 151
                       170       180       190
                ....*....|....*....|....*....|....
Feature 1                   ##  ##                
2FDR_A      155 QFGVsPDRVVVVEDSVHGIHGARAAGXRVIGFTG 188
4EEK_A      180 QLGIlPERCVVIEDSVTGGAAGLAAGATLWGLLV 213
gi 27375907 152 QMKVaPERCLVIEDSLPGVTGAHAAGMTVLGFHG 185
gi 27377901 155 TLGAhPSRCVVVEDSLSGICAAKAAGMRVLGFTG 188
gi 15595759 153 LLGVaPERCLVVEDSSTGTRAALAAGMRVIGFVG 186
gi 401623   154 AMNVnVENCILVDDSVAGAQSGIDAGMEVFYFCA 187
gi 15890531 156 SMGVePRQCIVIEDSPAGIAAAKAAGMGVFAFTG 189
gi 27378329 156 QMGAePARTLVIEDSVSGVQAGRAAGMTVWGFVG 189
gi 77463661 152 EMGVaPARCLVIEDTEPGVRAGLAAGMQVWRFTG 185
gi 21232151 152 TAGVaPERCLVIEDSPTGATAALAAGMQVLGFTG 185

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