4UAV


Conserved Protein Domain Family
HAD_CbbY-like

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cd07528: HAD_CbbY-like 
Click on image for an interactive view with Cn3D
subfamily of beta-phosphoglucomutase-like family, similar to Rhodobacter sphaeroides xylulose-1,5-bisphosphate phosphatase CbbY
This family includes Rhodobacter sphaeroides and Arabidopsis thaliana xylulose-1,5-bisphosphate phosphatase CbbY which convert xylulose-1,5-bisphosphate (a potent inhibitor of Ribulose-1,5-bisphosphate carboxylase/oxygenase, Rubisco), to the non-inhibitory compound xylulose-5-phosphate. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319830
View PSSM: cd07528
Aligned: 10 rows
Threshold Bit Score: 254.227
Threshold Setting Gi: 4433776
Created: 3-Apr-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
4UAV_A         5 ALLFDCDGVLVDTEKDGHRISFNDTFKEr-------DLNVTWDVDLYGELLKIGGGKERMTAYFNKv--GWPEKAPkdea 75
gi 124056460   3 ALIFDVDGTLADTESAHLQAFNAAFAEV--------GLDWYWDAPLYTRLLKVAGGKERLMHYWRMv--DPEEARGckv- 71
gi 22298345   19 ALIFDVDGTLADTERDGHRIAFNKAFAAa-------GLDWEWDIPLYGQLLAVAGGKERIRYYLECf--RPDWPRPqnl- 88
gi 27381949   15 ALIFDVDGTLAETEELHRQAFNHAFVRH--------GLDWHWDRAVYKDLLRVTGGKERIRAHHARlriARPLSDE---- 82
gi 4433776     4 ALLFDVDGTLAETEALHRRAFNEAFAAA--------GLPWRWTPQRYAELLRVAGGRERIAHFQSA---YPHEAAGivl- 71
gi 3913203     5 ALIFDVDGTLAETEEVHRQAFNETFAAQ--------GLDWYWSKEDYRTLLRTTGGKERMAKHRENl--GSGPSDA---- 70
gi 18408627   78 ALLFDCDGVLVDTEKDGHRISFNDTFKEr-------DLNVTWDVDLYGELLKIGGGKERMTAYFNKv--GWPEKAPkdea 148
gi 18420570   65 ALIFDCDGVILESENLHRQAYNDAFSHFdvrcppssSESLDWSLEFYDKFQNLVGGGKPKMRWYFKe-nGWPTSTIfdsp 143
gi 33240433    6 TVFWDLDGTIANTEMSGHRIAFNLAFSEy-------SLMWNWDEELYIRLLSIGGGLSRIIKYFEEi--NTYLSLE---- 72
gi 3023453     4 AILFDVDGTLAETEELHRRAFNETFAAL--------GVDWFWDREEYRELLTTTGGKERIARFLRH---QKGDPAPl--- 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              ##                        
4UAV_A        76 -----erkeFIAGLHKQKTELFMVLIEkKLLPLRPGVAKLVDQALTnGVKVAVCSTSNeKAVSAIVSCLLGper-aeKIK 149
gi 124056460  72 -------keTIDAVHAIKTRHYAERVGaGGLPLRPGIARLIDEAGEaGLPLAIATTTTpANLDALLQAPLGadwrrrFAA 144
gi 22298345   89 -------daLIADLHKAKTRYYTELLAaGAIPLRPGVKRLLTEAREaGLRLAIATTTTpANVTALLENALApdgvswFEI 161
gi 27381949   83 ---------DIAELHRVKTAHYAALIEtGCCPLRPGVTDLLTAAKArGQRLAIATTTShGNIDALLSRALGmrwaadFDA 153
gi 4433776    72 ------dpdAIATIHRDKNVRYAQMPRaGRLPLRPGVVRLAQEAAAsGARVAIVTTTSpENVAALLAALWPdda-ppFAA 144
gi 3913203    71 ---------KIADLHKAKTQRYVEIIAsGQVGLLPGVAELIDRAKAsGLRLAIATTTTrANVDALIAATFSkpagdiFEV 141
gi 18408627  149 -----erkeFIAGLHKQKTELFMVLIEkKLLPLRPGVAKLVDQALTnGVKVAVCSTSNeKAVSAIVSCLLGper-aeKIK 222
gi 18420570  144 pqndddrakLIDTLQDWKTERYKEIIKsGSVEPRPGVIRLMDEAKAaGKKLAVCSAATkSSVILCLENLIDierfqgLDC 223
gi 33240433   73 ---------QAKLIHKRKQFHYNSLVSaGKLDLRIGVSRLINELYSkNVKQWIVTTSSiLAVNAILNRYFPnhk-llFSG 142
gi 3023453    70 ---------PIADIHRAKTERFVALMAeGEIALRPGIADLIAEAKRaGIRLAVATTTSlPNVEALCRACFGhpareiFDV 140
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                  #                       ##  ##                
4UAV_A       150 IFAGDVVpkKKPDPAIYNLAAETLGVdpsKCVVVEDSAIGLAAAKAAGMTCIVTKS 205
gi 124056460 145 IGDAGTTaiKKPAPDVYLAVLERLGLeggDCLAIEDSANGLRAARAAGIPTVVTPT 200
gi 22298345  162 IAAGDVVpaKKPAPDIYFYTLEKMRLspqECLAFEDSANGIQAATASHLATIITIT 217
gi 27381949  154 IVAGDDVrhKKPAPDVYLEVLARLKMepfDCVAIEDSANGLIAASRANIPVLITRS 209
gi 4433776   145 IITARERaqKKPDPQAYHVALARLDIapsEAIAIEDTAHGAQAAAAAGIPVLVTES 200
gi 3913203   142 IAAGDEVaqKKPAPDVYLRALQGLGLppaACLAFEDSRAGLASARAAGLRVVLTPS 197
gi 18408627  223 IFAGDVVpkKKPDPAIYNLAAETLGVdpsKCVVVEDSAIGLAAAKAAGMTCIVTKS 278
gi 18420570  224 FLAGDDVkeKKPDPSIYITAAEKLGVsvkDCLVVEDSVIGLQAATKAGMSCVITYT 279
gi 33240433  143 IISGEDVncHKPDSEAYDLALKRSNSlpqNSLAIEDSIIGCQAAKSAQLKCIMTLS 198
gi 3023453   141 IAAGDMVaeKKPSPDIYRLALRELDVppeRAVALEDSLNGLRAAKGAGLRCIVSPG 196

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