3QGM,4JDP


Conserved Protein Domain Family
HAD_Pase_UmpH-like

?
cd07531: HAD_Pase_UmpH-like 
Click on image for an interactive view with Cn3D
UmpH/NagD family phosphatase, similar to Bacillus AraL phosphatase, a putative sugar phosphatase
Bacillus subtilis AraL is a phosphatase displaying activity towards different sugar phosphate substrates; it is encoded by the arabinose metabolic operon araABDLMNPQ-abfA and may play a role in the dephosphorylation of substrates related to l-arabinose metabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
?
PSSM-Id: 319833
View PSSM: cd07531
Aligned: 4 rows
Threshold Bit Score: 379.221
Threshold Setting Gi: 22095461
Created: 11-Jun-2008
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #####                           ####       #  #                            
3QGM_A         9 KGYIIDIDGVIGKSvtPIPEGVEGVKKLKelGKKIIFVSNNStrsRRILLERLRSFGLev-gEDEILVATyATARFIAre 87
gi 163848354   8 DGYIFDLDGTIYLGdiLLPGAAELLHTLRreGRRVTFLSNNPtktRRQYAERLQRLGIaa-dEHEIVNSSaVMVEWLLan 86
gi 22095461   14 AGILIDLDGTVFRGneLIEGAREAIKTLRrmGKKIVFLSNRGnisRAMCRKKLLGAGIetdvNDIVLSSS-VTAAFLKkh 92
4JDP_A        28 KGYIIDIDGVIGKSvtPIPEGVEGVKKLKelGKKIIFVSNNStrsRRILLERLRSFGLev-gEDEILVATyATARFIAre 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         # #           #
3QGM_A        88 kpnaKVFTTGEEGLIEELRLAGleivd--ydeaEYLVVGsnrkinFELXTKALRaclrgIRYIATNPDRIFPaedgpIPG 165
gi 163848354  87 apgaSLFVVGEAPLIGELEAAGfplse-kpgeiAFVVASfdrtftYRKLQIAFDairagARLVATNPDRFCPvpgggEPD 165
gi 22095461   93 yrfsKVWVLGEQGLVDELRLAGvqnasepkeadWLVISLhet-ltYDDLNQAFQaaaggARIIATNKDRSFPnedgnAID 171
4JDP_A       107 kpnaKVFTTGEEGLIEELRLAGleivd--ydeaEYLVVGsnrkinFELMTKALRaclrgIRYIATNPDRIFPaedgpIPG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #                       ###  ##                            
3QGM_A       166 TGXIIGALYWXtgrepdvvVGKPSEVIXREALDIlgldaKDVAVVGDQIDVDVAAGKAIGAETVLVLTGVTTRENldqxi 245
gi 163848354 166 AAAIIAAIEACtdtrceviVGKPSPIMARTVTNLiglppERCIIVGDRLMTDIAMGVTAGMDTALVLTGDSQRADle--- 242
gi 22095461  172 VAGMIGAIETSaqaktelvVGKPSWLMAEAACTAmglsaHECMIIGDSIESDIAMGKLYGMKSALVLTGSAKQGEq---- 247
4JDP_A       185 TGMIIGALYWMtgrepdvvVGKPSEVIMREALDIlgldaKDVAVVGDQIDVDVAAGKAIGAETVLVLTGVTTRENldqmi 264
                        250
                 ....*....|....*...
Feature 1                          
3QGM_A       246 erhGLKPDYVFNSLKDXV 263
gi 163848354 243 -rsPYQPTYVLERIDELI 259
gi 22095461  248 --rLYTPDYVLDSIKDVT 263
4JDP_A       265 erhGLKPDYVFNSLKDMV 282

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap