Conserved Protein Domain Family
HAD_like

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cd07533: HAD_like 
uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily, similar to Parvibaculum lavamentivorans HAD-superfamily hydrolase, subfamily IA, variant 1
This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319835
View PSSM: cd07533
Aligned: 8 rows
Threshold Bit Score: 265.801
Threshold Setting Gi: 385234564
Created: 8-Apr-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
gi 15677666    6 LIIFDWDGTLADTtqpiidtmrrsfaecgfpppeaervrsLIGYSLpeiirtllemps-----------etavaditrty 74
gi 26988636    7 LLIFDWDGTLADSigriveamnvaaerageaqssdaavkgIIGLALdeaihtlyphlapaev----asfrqhyadvyval 82
gi 83593990   12 LAIFDVDGTLADSqhnivgamtdafrahgladpdpaavraIIGLSLveavarvlpeappdqva-vvaqsykqafvtrrmg 90
gi 115422195   5 LVVFDWDGTLMDSthsivaaiqaaardldlpvpsaseaswVIGLSLesalkravpqltpal-----lprfleryrihyll 79
gi 385234564   3 LVIFDVDGTLIDSqnnivasaeaafaalslaaparadvlrLVGLSLpetmvrlaptatqalrd--dlvqaykdsfrtmrl 80
gi 15888796    3 LVLFDCDGTLVDSaglihavmsetfadfgkprpdisetkaIIGLTLdiaiarmlgrahvddeaaamalrykenyhplrer 82
gi 154157159   7 LVVFDCDGTLIDSqhmivaamahafetyglenlprekvlsIVGLSLdeaihalvpdveeplrr-rlteaykgafhelrnr 85
gi 144899542  16 LVVFDVDGTLIDSehniiaamteawahmdlgvpepadvrrIIGLSLveacqvllpwapgnlhr-avaesykqafralrll 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            ##                              #           
gi 15677666   75 sAHYlnpnnrnmSLFPDALPCLDKlk-aqGYWLAVATGKGRAGLDNAISqtatggYWLATACAGEYpSKPSPEMVFGICg 153
gi 26988636   83 dQQPs-------PLFDGVVESLDAfr-aeGYRLAVATGKARRGLDRVLKangwerFFDITRAADETrGKPHPLMLEEILg 154
gi 83593990   91 pAYTe-------QLFPGAAEAVRDla-arGVVLALATGKSRRGVDVFLErhglegLFDAVRTADDGpGKPDPWMLNDILa 162
gi 115422195  80 rDPEl-------RLFDGVRELLDSla-nqDVRLAVATGKSRVGLNRVLAatglgpVFDATRTADETfSKPHPEMLHQLMn 151
gi 385234564  81 qGHDa-------PMFPGARDAVLQlagapGTMLAIATGKSRRGLEAMLDqhelrgLFHSTQVADDHpSKPHPSMVLAALa 153
gi 15888796   83 fENAt-------PLFDGIASLIDMlskrdDVLIGAVTGKGRRGLTQILEthgfadHFIVSRTADDCpSKPHPAMVMECCh 155
gi 154157159  86 kELAe-------PLFPGVRETLEAlaareNVLLGIATGKSQRGLRHALEthelghYFVTLQTADDApSKPHPEMLRRAMr 158
gi 144899542  95 pEREe-------PLFPGVREALDEle-aaGWLLGLATGKSQRGVQSMLDshdlhgRFINIQTADDNpGKPDPAMLRRASa 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                    ##  ##                                        
gi 15677666  154 elgldpkeALVVGDTAHDLHMAANAGAAAVGVATGAHsreqll-saphlAVLDGLSEL 210
gi 26988636  155 hcgvepsrALMVGDSAFDLQMASNAGMHSVAVGYGAMslqala-efgpqVCIDHFSQL 211
gi 83593990  163 tlgcdagsTAMVGDTTYDVEMAVRAGIHAVGVAWGYHaqadlraagatlIVQEFGQVA 220
gi 115422195 152 dldvdpsrVVMVGDTTHDLQMAVNAGVHGLGVSYGAHslselq-scsaeAVVHSVPEL 208
gi 385234564 154 etgvaarhAVMVGDTSFDMDMAAAAGVRRIAVGWGYHapel----lvadHHISRFDEL 207
gi 15888796  156 etgmvpadTIVIGDAIYDMQMAKAAGAKAIGVAWGYAsvedlw-kagadAVVNHPNDI 212
gi 154157159 159 aagadardTVLVGDTSYDMAMARAAGAHAFGVDWGYHapemlr-vagadIVLSDFSGL 215
gi 144899542 167 etgvdlarMVMIGDTAYDMQMAKSAKVAGLGVSWGYHglqelh-dagavQVVDSFDTL 223

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