Conserved Protein Domain Family
P-type_ATPase

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cd07538: P-type_ATPase 
uncharacterized subfamily of P-type ATPase transporters
This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.
Statistics
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PSSM-Id: 319839
View PSSM: cd07538
Aligned: 5 rows
Threshold Bit Score: 951.5
Threshold Setting Gi: 196187140
Created: 16-May-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305  12 GLTKEEAKKAQEKhGKNqlipekkenfflkilevLKEPMFLLLLVAATIYFILGeprDGTIMLIFVVGIISIDVIQEWKT 91
gi 44920840   13 GLTDLEVKQYRETyGKNellqkkkktllsrilkiLTEPMFVLLFIAAFIYFFLGeprDGSIMVISVIFICAIEFFQEWRT 92
gi 167729725  23 GLTTKEVEEKLRReGYNelpgskgrnlgkliwdiISEPMFILLVACAVIYFFLGdlqEALVLTASVVIVMSIELIQERKT 102
gi 196187140  20 GLEEAEARRRLESgGPNslqqpenrtirasvydaAREPMLLLVAAAALLYLVIGdhgEGLFLIGGVVVTLALVVVQDLRG 99
gi 27378926   11 GLSEVEARARLEEdGANelprperrsplrivmevLREPMLVLLLCGGLVYLVLGdlrEALILLVFGAMSIVITVVQETRT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305  92 DktlmaLKNLSAPQVTVIrdgvETTINSEDLVPGDLMIITeGVKIPADGKVTkcndLCVDEStLTGEAEGVWKSiddssn 171
gi 44920840   93 DrtlqaLKELSSPKSTVIrngkMMTIDSTELIVNDLLILKeGEKIAADGIIVenygLGVNEStLTGESDVVWKKidlked 172
gi 167729725 103 EkaleaLKNLSSPRALVIrngeQIRIPGREVVTDDLIILAeGDRIPADAYILendlLSVDESlLTGESVPVRKRiwdkke 182
gi 196187140 100 EralaaLRTLAQPSARVIrdgrERRIPTQDLVPGDLVLVGeGERLPADCRLLggdmLGVDESaLTGESATVLKTpgga-- 177
gi 27378926   91 ErvleaLRDLSSPRALVVrdgaRRRIPGREVVRGDLLVLGeGDRIPADAALVdardLQIDESlLTGESVPVRKRaagkam 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 172 k-----dfwkknYCYaGTIViqGSGVVKVEKIGskteyGKIGINVSEAvqsatpMQKQIRKLVKVCAYMAEVLFALVCLv 246
gi 44920840  173 et---lehwkknICYaGTSVtqGRAVVKVIHIGseteyGKIGKDIFSVesmptpLEKQTEKLVKYSAIAAFFMLLLIVLv 249
gi 167729725 183 rps-tpggddlpFVYsGTLVvsGRGIAQVFATGertelGKIGKSLETIteeetrLSKETGRLVKYFAIFALLICAFVVIv 261
gi 196187140 178 --------gddaRLFaGTLIvrGHAVAEVVLTGartalGRIGGALAEMddeptpLQRSSGRLVRLLGLAALVFCALITAa 249
gi 27378926  171 sadqrpggedqpFVYsGSLVvrGEGLALVEATGprseiGKIGLSLRGLqtepprLRQQTARLVRLCFLGGAVVSVAAVAl 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                ####### 
gi 187722305 247 tfvnlsdigfkdrliqsilsGITLAMAMIPEEFPVILTVFLSMGAWRLAkknsLVRKLPSVETLGaisVLCVDKTGTITK 326
gi 44920840  250 nfyyrgs------vtdsilsGVTVAMAIIPEEFPVILTVFLAMGAWRLAnknsLIRRIPAVETLGsisLLCVDKTGTLTK 323
gi 167729725 262 fyvtrkh------linalltGITLAMSVLPEEFPVVLTVFMALGAWRMSkknvLVRRLQAIESLGsatVLCTDKTGTITY 335
gi 196187140 250 ygltrgd------wmeailaGMTFAIALIPEEFPMILTVFMALGAWRLArhnvLVRRAAAVEALGgvtLLCVDKTGTLTE 323
gi 27378926  251 ygvlrgd------wlqallaGIAIGMAMLPEEFGVVLTVFMAMGAWRISqarvLTRRAAAIEVLGsatVLCTDKTGTLTQ 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 327 NKMTVTDIWSinndidllsrtmgmaceteaydq----------------meqamikycednnitkdelfngtLINEYSFT 390
gi 44920840  324 NQMEVKETYFdskfnetelmtyaclaseteaydp---------------mekaimiysksirinidelctgcLLHEYPFS 388
gi 167729725 336 NKMTLQKIVSnsenielknsaklsepilntlihsvlgsmr---epfdpmekaihnalndldpsiyaelqtyqEIREYPLT 412
gi 196187140 324 NRMELVRLTVdgvdhaiadglpasgaavlrtaal--------------asarrsidpmdravlrlsaapesdPVRSWPLR 389
gi 27378926  325 NQMSVAELRLldgarmrpesagrddarpefielarcgalasspepfdpmekalhlfaqdalrggdapdgdrtLVRTYGLR 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 391 nERKMMGHVWKse--dgITLTSKGSPEKImelcnlsnvnkkKIEDKIYEMSskSLRVIAVAnmkidneenvpkeledckL 468
gi 44920840  389 sETRMMGNVWNkd--nkKFIALKGSFENIinlcdlkesekvNLEKKSIEMAkkGYRVIAVAkkmdvvti--nqhldeytF 464
gi 167729725 413 dELRAMAKVWKisgktnYTVALKGSPEAViklcsvnteeinAIMKQVSDLAeeGLRVLGIAsceiktdvl-pekltdlsF 491
gi 196187140 390 pEKPVVVQLWSrp--egAFAAAKGAPEAVfrlcrltpdqaaAQLRAVDRLAgeGLRVLAVAacrtsesf--pddpweavF 465
gi 27378926  405 pELLAMTQVWRtagradLVACAKGAPEAIarlcrmnaadqdSVRDAASAMArdGLRVLGMAvaacddasl-pptqedfaF 483
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 469 NFLGLIGLQDPPRESIKVDISRCEeAGIRVVMITGDNGITASSIAKQIGIshnnqiitgemlnnmsdeelkekiedvSIF 548
gi 44920840  465 EFVGLIGLMDPPREGVSKAMKICNnAGIRVVMLTGDNGTTAKSIAKTIGLknsenvltgneidsmgdeellekinvtNIF 544
gi 167729725 492 CYLGLIGLADPIRETVPEAVKICYkAGIRVIMITGDYIGTAKAIGKQIGLknvdniisgseldqmsdeelaekckqvSIF 571
gi 196187140 466 IYEGLLGFVDPLRPDAAAALRDACeAGIAVAMITGDHPATALAIAREAGLdetagvmtgqdvaalsqealpsrvrdvRIF 545
gi 27378926  484 RFVGLVGLADPLRPHVPEAVRECRaAGIRVVMITGDYPATAVAIANQAGLdvrdvmtgdqvrl-addpelakrvghvNVF 562
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 549 SRVVPEHKMRIVKAFRengevVAMTGDGVNDAPALKYADIGIAMGkRGAEVSREAADLILLDDNFSTIvdTIEDGRRIYD 628
gi 44920840  545 SRVIPKHKLRIIKAFKklgeiVAMTGDGVNDAPALKYADIGVAMGkRGTEVAKEASDMILLDDNFETIveTIHDGRRIYD 624
gi 167729725 572 ARVVPQQKLRIVQALKangeiVAMTGDGVNDAPALKAANIGISMGlRGTDVAREASAIVLTDDDFSSIvsAVKMGRRIYD 651
gi 196187140 546 ARVTPDQKLRLVQAFKaaggvVAMTGDGVNDAPALEAAHIGIAMGrRGTDVAREAADIVLLDDRFASIigGVRLGRRIFA 625
gi 27378926  563 ARVLPEQKLRIVQAMKlngeiVAMTGDGVNDAPSLKAAHIGIAMGgRGTDVAREASAIVLLDDDFGSIvsAIRLGRRIYD 642
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 187722305 629 NIKKAIGYVFTIHIPIALISLLGPLLGissfnllllPVHVVLLELIIDPTCSIVLErqraekdiMKRKPRnpnesivpsn 708
gi 44920840  625 NIKKAIGYVFVIHIPVFLTALFAPLLKlpl---lllPINVVLMEFIIDPTCSIVFErqpaekniMLRKPRmpteplldys 701
gi 167729725 652 NLRKSFTYVFSLHVPIAGMAMIPASFAdypi--iyfPVHIAFLELIIDPACSIVFEmekeeddiMERPPRsvdeklfgtk 729
gi 196187140 626 NLQRALTYVTAIHVPIAGLALAPVLLGlpp---llfPLHVVLLELAVDPICALVFEaepsernaMRRPPRpagsplfgpr 702
gi 27378926  643 NLRKAMAFIFAVHVPIAGLALLPLVFGlpl---ifsPVHIAFLELIIDPVCSLVFEaerderdaMTRPPRrpdaalfswa 719
                        730
                 ....*....|
Feature 1                  
gi 187722305 709 iliksiTQGL 718
gi 44920840  702 lifkaiIQGV 711
gi 167729725 730 rliigfLQGL 739
gi 196187140 703 qviaalAQGA 712
gi 27378926  720 lvgwsvLQGA 729

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