Conserved Protein Domain Family
P-type_ATPase

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cd07539: P-type_ATPase 
uncharacterized subfamily of P-type ATPase transporters
This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.
Statistics
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PSSM-Id: 319840
View PSSM: cd07539
Aligned: 9 rows
Threshold Bit Score: 719.199
Threshold Setting Gi: 21220960
Created: 16-May-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166  742 DDLSYEPVMAPLRGPartlaq--------------------------lavatRHELADPLTPILAVGAAASAIVgsniDA 795
gi 54016191   748 PGLDERAEAQRSRLGaalaplapa-------------------vsfgrqlrrELADPLTPILGVGAVATAILGSp--sDA 806
gi 17132340   126 SGLSSESAAANLSIYganilsetei------------------rssfsilvdQFKSLPVALLGVAAGVSVFTGGl--iDA 185
gi 21220960   639 DRAGRVPVLAPVRWSwqlar----------------------------avrgELDDPLTPVLAVGSAASAILGSv--vDA 688
gi 198286001  229 PWHAMPPDAALSTLAsserglsestaasrhqk----rdrartrtgiarataaGLITPITPVLGAGAVVSAGLGSv--vDA 302
gi 31791603   643 PDEQAPAKAPPSPYParalagglhtakrgaq-----itqaplnalwqltkavRAELSDPLTPMLALGAMASAVLgspvDA 717
gi 614134171  742 DDLSYEPVMAPLRGPartlaq--------------------------lavatRHELADPLTPILAVGAAASAIVgsniDA 795
gi 53756069   123 SWHALDAEEVLSRLSanrdglgaavvaerlarygrnvlteikprsavamflgQFASPPVALLGLSAAVSIATGGm--aDA 200
gi 196188655   35 QGLVEADARSRLDRYgpnqlpetap------------------rsgisiffaQLITLPVALLTAAAGLSLVTDGr--lDA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166  796 LLVAGVMTVNAITGGVQRLRAEaaaaeLFAeqdqLVRRvvvpavattrrrleaarhatrtATVSAKsLRVGDVIDLaaPE 875
gi 54016191   807 ILLSSVLTVNAVVSARQRQRAEhalqdLMAdeelTARLvgrs--------------gdaeQVIPAHrLRVGDLIRLraGD 872
gi 17132340   186 VVILGVVGVNAVIGYATETQSEriihsLKHqeqtSAWVmrd----------------gkaQEIPVEnVVVGDVLILkpGS 249
gi 21220960   689 LLVVGALDLNALVGGFQRLRAEralsgLLAeqkqKARVaeeqlrpet----aeftpegepRIVDAAkLHPGHVIELraDD 764
gi 198286001  303 ALIVGVLLASALVDGVQRVATDreltrLLDagqvPARRrre----------------gavEVVPADqLVPGDVVELraGD 366
gi 31791603   718 VMVGSVLTGNSILAASQRLRAEsrlnrLLAqqipPARKvlagad-----------dqpryIEVRAEeLRPGDIIEVrtHE 786
gi 614134171  796 LLVAGVMTVNAITGGVQRLRAEaaaaeLFAeqdqLVRRvvvpavattrrrleaarhatrtATVSAKsLRVGDVIDLaaPE 875
gi 53756069   201 VVIVGVVLINAVIGYFTEAQAQktidaLGKigptHALVmrd----------------gvkRSVPLEeVVPGDILVLspGS 264
gi 196188655   95 AIIMGVVGINAVIGYITESQSEkiiraLRTqeslDTDVira----------------gqtQTIETSsVVPGDLLSLrvGE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166  876 VVPADARLLvaedLEVDESfLTGESLPVDKQvdpvav---ndpdraSMLFeGSTIvaGHARAIVVATGvgtAAHRAISAV 952
gi 54016191   873 VVPADARLIelddLELDESgLTGESVTVEKQlaatpga--algdraCMVFeGSTVvsGAGTAVVVAVGadtQAGRAAAGA 950
gi 17132340   250 YVAADARLIeadnLSIDESaLTGESLPASKNtafltgedvplgdrlNMIYrGTYItgGQGLAAVVATGqftEMGHIQTLV 329
gi 21220960   765 VVPADARLLwedgLEVDESaLTGESLPVDKCvdpapra--pvaeryCMVFeGTTVvaGRARAVVVDTGdhtEAARAVALA 842
gi 198286001  367 GVPADCRLLstdgLEVDESsMTGESQLVVKDtaattap--evadrtCMIYqGTAVasGTGSAVVVAVGthtEVGRTARTS 444
gi 31791603   787 VVPADARVIeevdVEVDESaLTGESLSVTKQveptpgv--dlierrCMLYaGTTVvsGTAVAVVTAVGpdtQERRAAELV 864
gi 614134171  876 VVPADARLLvaedLEVDESfLTGESLPVDKQvdpvav---ndpdraSMLFeGSTIvaGHARAIVVATGvgtAAHRAISAV 952
gi 53756069   265 YIAADARLLasnrLTVDESaLTGESLPVDKRhtfvgtkdtplgdrkNMLHmGTIVtgGSGRAIVVATGrhtEIGLIQSLV 344
gi 196188655  159 TVAADARVVlsqgLTLNEAaLTGESRPVEKTvqalaagerplaergNMVYkGTLVtsGQGQAIAVATGpktELGNIQQLV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166  953 ADVet-aaGVQARLRELTSKVLPMTLAGGAAVTALALLRraslrqavadGVAIAVAAVPEGLPLVATLSQLAAAQRLTar 1031
gi 54016191   951 MPPek--gGVQAQLRRLTDRALPLTLAGGTAVTALGGLRrqplrtaiadGVGVAVAAVPEGLPLVATVAQLAAARRLSrf 1028
gi 17132340   330 GTAnatetPLARQLDQVGSQLVVIGMGLCGLVFGMGVLRgyglvqmlksSISLAVAAVPEGLPTIATTTLALGIRDMRrn 409
gi 21220960   843 ARTps-aaGVQARLQELTRKALPLTLAGGAAVTGLSLLRgapirqavagGVSVAVAAVPEGLPLVATVAQLAAARRLSrr 921
gi 198286001  445 APEtg--nGVEARLGELTKKLLPVSIGAGGALFAADLLRgvplgrtvarSVGLAVAAVPEGVPFVATLAELAAARRLAar 522
gi 31791603   865 SGDls-svGLQHQLSRLTNQAWPVSMTGGALVTGLGLLRrrglrqavasGIAVTVAAVPEGMPLVATLAQQASARRLShf 943
gi 614134171  953 ADVet-aaGVQARLRELTSKVLPMTLAGGAAVTALALLRraslrqavadGVAIAVAAVPEGLPLVATLSQLAAAQRLTar 1031
gi 53756069   345 GEVktpetPLQRQLDEMGKQLALASSGICAFVFGLGVLRgapalqmlktAISLAVAAVPEGLPTVATSTLALGIREMKkr 424
gi 196188655  239 DSAtaadtPLQSQLNQLGTQLVALSCGICALIFGIGVVRgyallpmlkiAISLAVAAVPEGLPAIATTTLALGIREMRrr 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #######                                                    
gi 614134166 1032 GALVRSPRTIEALGRvDTICFDKTGTLTENRLRVVCALPsstaaerdplpqttdapsaevlraaarastqph-------- 1103
gi 54016191  1029 GVLVRASRTVEALGRvDTLCFDKTGTLTEGKLRLTTLADldeqwepdtdsdrarrllraaaracpdp------------- 1095
gi 17132340   410 KVLVRSLSAVEALGSvQTICLDKTGTITENKMSVVEIHTntreikvtdgefiaggeninpymydellklihvsvlcne-- 487
gi 21220960   922 GVLVRTPRTLEALGRmDTVCFDKTGTLTENRLRLSRVAGadgtvrrsgdpetadtvrtaaracprl-------------- 987
gi 198286001  523 GVLVRSPATIEALGRvDALCFDKTGTLTQGRISLGQVSDgrtaqptahlddrhreivaagvratprq------------- 589
gi 31791603   944 GALVRIPRSVEALGRvDMVCFDKTGTLSENRLRVAQVRPvaghsreevlrcaahaapasngpqvha-------------- 1009
gi 614134171 1032 GALVRSPRTIEALGRvDTICFDKTGTLTENRLRVVCALPsstaaerdplpqttdapsaevlraaarastqph-------- 1103
gi 53756069   425 HVLIRQLPSVESLGSvQTLCLDKTGTLTENCMRVVSLRTpeldiglsatgefrsngrtirpagaedlrrlmqvvclcsev 504
gi 196188655  319 QIFIRTLAAVESLGAiQTICLDKTGTLTENKMAVSAVQVnashfhdfsiqngpqsgplqsgllqseqesqsvgtestads 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166 1104 -----------------------------------------ngeghahatdeailaaasalagslssqgdsewvVLAEVP 1142
gi 54016191  1096 ----------------------------------------------adgpvlhatdravldaaevlgdeahrwdPIEEIP 1129
gi 17132340   488 -----------------------------------sevsrddgeyvvtgsatenaliymgiaagvdaialkdkyPLLQTN 532
gi 21220960   988 ------------------------------------------------dgdgarpthatdeaildaagddpgwtQEEGLP 1019
gi 198286001  590 ----------------------------------------------ndehplphltdravldgaraagvtadetVLAELP 623
gi 31791603  1010 ------------------------------------------------tdvaivqaaaaaaasgtdgaepgaaePAAHLP 1041
gi 614134171 1104 -----------------------------------------ngeghahatdeailaaasalagslssqgdsewvVLAEVP 1142
gi 53756069   505 qlngdpdrs---------------vppgsqrvdaeplsadasgrsglegsptemalvemamhagedvaalrrslPLIKTV 569
gi 196188655  399 ltdatnseidysllklmeiavlcsdvqleiqadgsasmtgsatetalvdmataagldaadlrrqypliasylrtQTHPVM 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166 1143 FEs-SRGYAAAIGRvgtdgiPMLMLKGAPETILPRCrladpg--------vdhehAESVVRHLAEq-GLRVLAVAQrtwd 1212
gi 54016191  1130 FEs-NRGYAAAIGQtt--rrLRLVVKGAPEVVLPRCskvrtgdqpkqalteelreRAVRRVAELAeqGLRVLVVARrdla 1206
gi 17132340   533 LRseNRNIMSTIHEthn-ghKFVAVKGSPGEVVQMCqgwmkdgqv-vpltdadrqMLEIENDRMAgkALRVLGVAYnhid 610
gi 21220960  1020 FEt-SRGYAAAVGRedgtgaAVLVVKGAPETVLPACagl--------------pdHALEVAQRLAgaGLRIIAVARrtld 1084
gi 198286001  624 FEp-SRGFHAVRVD------GLLSVKGAPEVVLDRCarrrtaags-eefdaaaraEVEHEIERLAadGYRLLAVAErtat 695
gi 31791603  1042 FRs-GRSFSASVSG------TELTVKGAPEVVLAACegi-------------gssMDDAVAELAAn-GLRVIAVAHrqlt 1100
gi 614134171 1143 FEs-SRGYAAAIGRvgtdgiPMLMLKGAPETILPRCrladpg--------vdhehAESVVRHLAEq-GLRVLAVAQrtwd 1212
gi 53756069   570 HRaeGRPYMLTVHDtgg-eeHLIAVKGSPTHVLALCdrrmegggvpvpldddtraAIVEQNELMAgqALRVLGVAYghcr 648
gi 196188655  479 STv-HQVIAAEQTT------ILTAVKGNPAAVLSQCdrqlqgeqv-vmlteadrqRIEQNNQQLAdeALRVLGFAYhqet 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166 1213 ngtthddet-dadavdavahdlELIGYVGLADTARSSSRPLIEALLDaERNVVLITGDHPITARAIARQLGLpad--arV 1289
gi 54016191  1207 drped---------medavgelTLLGFLGLADTPRPQTLPLVKSLQDnGIGVRMITGDHPVTAAAVAKQLGIev---geV 1274
gi 17132340   611 eshn-----------gnhetdlIWLGLVGMADPIRRGAKALIADFHHaGIDTVMITGDQSPTAYAIAKELELnrhtqleI 679
gi 21220960  1085 tgeraa------dvlerqpselEFTGLLALADVARETSPALVRGLREaGVRPVVLTGDHPQTAHAIAVDLGWped--avV 1156
gi 198286001  696 aatgl---------tesdvddlELVGLLGLADPVHPAAAEAVAQLSGaGVDVIMITGDHPSTAGAIAAELGVlgg--krV 764
gi 31791603  1101 aqqaqsvvddpdeiarlcrdelSLVGFLGLSDTPRAQAAALLADLHEhDLDIRLITGDHPITAAAIAEELGMqvs-peqV 1179
gi 614134171 1213 ngtthddet-dadavdavahdlELIGYVGLADTARSSSRPLIEALLDaERNVVLITGDHPITARAIARQLGLpad--arV 1289
gi 53756069   649 dtst-----------aavseklVWLGMVGMEDTMRPGMAELMAQFHDaGIDTVMITGDQSATAFAFGSRLNLnddkpleI 717
gi 196188655  551 lsvtn--------skpktknnlIWIGLAGLSDPIRAGVSDFIAAFQQaGIRTVMITGDQSSTARAIAQTLHIsrqtevsV 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166 1290 VTGAELAvldeeahaklaadmQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSgrGSSAARGAA 1369
gi 54016191  1275 TTGADLDrldetaqieriersTVFARVSPEHKVRIVAALRKAGHVVGMTGDGSNDAAAIRTADVGIGLAahGSAAARNAA 1354
gi 17132340   680 LDSTNLNnltpealtalsdkvDVFARISPSNKLQVVQALQGAGKVVAMTGDGINDAPALKAAQVGVAMGkgGTDVAREVA 759
gi 21220960  1157 VTGDELAaadrtarsrmlrdaDVVARVAPEQKLQVVESLRDAGRVVGMVGDGANDAAAIRAADIGVGISarGSAAARNAA 1236
gi 198286001  765 LTGAELDrlddeqltgelpgiAVFARVSPAQKARIVSRLRDAGRVVAMTGDGANDVPAINLAQVGIAFGsrATPAAREAA 844
gi 31791603  1180 ISGAEWDalsrkdqeravaerVIFARMTPENKVQIVQTLEHSGRVCAMVGDGSNDAAAIRAATVGIGVVahGSDPARVAA 1259
gi 614134171 1290 VTGAELAvldeeahaklaadmQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSgrGSSAARGAA 1369
gi 53756069   718 VDSTNLDeldpdvlkgivrdtTVFARVAPAQKLRIVQALQANGRVVAMTGDGINDGPALKAADVGVALGn-GSDVARSVA 796
gi 196188655  623 MDAITLSdlstnpp-vgfeqiDVFSRVSPAHKLAIVQTLQAAGTIVAMTGDGINDTPALKTANVGIAMGagSSHGVHEVA 701
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 614134166 1370 DIVLTDddlGVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAgrapvgTRQLLLVNLLTDMFPALAVAVT 1449
gi 54016191  1355 DMVLTDadpTALLHALVEGRGMWQRISAAVGVLVGGNAGEVAFTLYGTAVSGhap-lgTRQFLLVNMLTDMFPALALALA 1433
gi 17132340   760 DIVLEDdrlETMIIAVSRGRTIYNNIRKSVHFLLATNLSEIMVMTTATAVGIgep-lnAIQLLWLNLVTDIFPGLSLAME 838
gi 21220960  1237 DLVVTGddlLVLVEAVREGRALWHSVADAIAILIGGNAGEVGFGILGTVLGGaap-lsTRQMLLVNLFTDLFPAMAVAVT 1315
gi 198286001  845 DLVVAEdriETLTDGVVEGRGMWTSVRDALSVLLGGNLGEIGYALGTGLLSPaag-lnARQLLVVNLLTDVLPAIAIAVR 923
gi 31791603  1260 DLVLVDgriESLLPAILEGRQLWQRVQAAVSVLLGGNAGEVAFAIIGSAITGtsp-lnTRQLLLVNMLTDALPAAALAVS 1338
gi 614134171 1370 DIVLTDddlGVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAgrapvgTRQLLLVNLLTDMFPALAVAVT 1449
gi 53756069   797 DVVLEDdnlHTMIIAVQQGRTIYRNIRKSLAYLLSGNLAEIEIMLVATAIGAgea-lnPMQLLWINLVTDILPAVGLSLE 875
gi 196188655  702 DVVIGDnnlKTLVDALSRGRTTYLNIRKSVHFLLSTNLSEIMVTALVTAIAVgsp-ltVMQLLWLNLVTDVFPGLALALE 780

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