1W25,2W01,1WC0,1CJK,2V0N,3BRE,3EZU,1FX4,1YBU,1Y10,1YK9,1AB8,3ET6


Conserved Protein Domain Family
Nucleotidyl_cyc_III

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cd07556: Nucleotidyl_cyc_III 
Click on image for an interactive view with Cn3D
Class III nucleotidyl cyclases
Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.
Statistics
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PSSM-Id: 143637
View PSSM: cd07556
Aligned: 13 rows
Threshold Bit Score: 114.376
Threshold Setting Gi: 56966618
Created: 28-May-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
nucleotidylmetal binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotidyl binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70        80
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ######                                             #                     
1W25_A    319 PVSALLIDIDFFKkindtf----ghdigDEVLREFALRLASNVra----iDLPCRYGGEEFVVIMPd------------- 377
2W01_A     14 PITILTSDLRGFTstsegl----npeevVKVLNIYFGKMADVIth---hgGTIDEFMGDGILVLFGapts---------- 76
1WC0_A     27 LITILFSDIVGFTrmsnal----qsqgvAELLNEYLGEMTRAVfe---nqGTVDKFVGDAIMALYGapeem--------- 90
1CJK_A     26 NVSILFADIEGFTslasqc----taqelVMTLNELFARFDKLAae---nhCLRIKILGDCYYCVSGlpea---------- 88
2V0N_A    319 PVSALLIDIDFFKkindtf----ghdigDEVLREFALRLASNVra----iDLPCRYGGEEFVVIMPd------------- 377
3BRE_A    202 QLSLLMIDVDYFKsyndtf----ghvagDEALRQVAGAIREGCsr---ssDLAARYGGEEFAMVLPg------------- 261
3EZU_A    213 NVGIXLIDLDYFKlvgdny----ghqtgDRILQLVAETITSHLrr----sDVVGRYDGDEFVVYLSp------------- 271
1FX4_A     12 PVTLIFTDIESSTalwaa-----hpdlmPDAVATHHRLIRSLItr---yeCYEVKTVGDSFMIASK-------------- 69
1YBU_A     17 LATIMFTDIVGSTqhaaal----gddrwRDLLDNHDTIVCHEIqr---fgGREVNTAGDGFVATFT-------------- 75
1Y10_A    215 QVTVAFADLVGFTqlgevv----saeelGHLAGRLAGLARDLTap----pVWFIKTIGDAVMLVCP-------------- 272
1YK9_A     10 EASVLFADIVGFTerasst----apadlVRFLDRLYSAFDELVdq---hgLEKIEVSGDSYMVVSGvprp---------- 72
1AB8_A     14 CVCVMFASIPDFKefytesdvnkeglecLRLLNEIIADFDDLLskpkfsgVEKIKTIGSTYMAATGlsaipsqehaqepe 93
3ET6_B      9 EATVLFSDIVGFTeiasrs----splevXSLLDELYQRFDAAIeey--pqLYKVETIGDAYMVVCNvtvp---------- 72
                      90       100       110       120       130       140       150       160
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     
1W25_A    378 ---tALADALRIAERIRMHVSgspftva-------------------------------hgremlnVTISIGVSAtageg 423
2W01_A     77 -qqdDALRAVACGVEMQLALRevnqqvt--------------------------------glglqpLEMGIGINTgevvv 123
1WC0_A     91 spseQVRRAIATARQMLVALEklnqgwqerg--------------------------lvgrnevppVRFRCGIHQgmavv 144
1CJK_A     89 -radHAHCCVEMGMDMIEAISlvrem------------------------------------tgvnVNMRVGIHSgrvhc 131
2V0N_A    378 ---tALADALRIAERIRMHVSgspftva-------------------------------hgremlnVTISIGVSAtageg 423
3BRE_A    262 ---tSPGGARLLAEKVRRTVEslqishd-------------------------------qprpgshLTVSIGVSTlvpgg 307
3EZU_A    272 ---vEPASLRTVAENLRRSIEeesa-------------------------------------rxvpVTASIGVAQgilgt 311
1FX4_A     70 ----SPFAAVQLAQELQLCFLrldwetnavdesyrefeeqraegeceytpptasldpevysrlwngLRVRVGIHTglcdi 145
1YBU_A     76 ----SPSAAIACADDIVDAVAal------------------------------------------gIEVRIGIHAgevev 109
1Y10_A    273 ----DPAPLLDTVLKLVEVVDtdn----------------------------------------nfPRLRAGVASgmavs 308
1YK9_A     73 -rpdHTQALADFALDMTNVAAqlkdp------------------------------------rgnpVPLRVGLATgpvva 115
1AB8_A     94 rqymHIGTMVEFAYALVGKLDainkh------------------------------------sfndFKLRVGINHgpvia 137
3ET6_B     73 -cddHADVLLEFALRMHEEASrvass------------------------------------lgepVRIRVGMHSgpvva 115
                     170       180       190
              ....*....|....*....|....*....|....*..
Feature 1                          #               
1W25_A    424 d-----------tpealLKRADEGVYQAkasgrnAVV 449
2W01_A    124 gnigsekrtkygvvgaqVNLTYRIESYTtg---gQIF 157
1WC0_A    145 glfgsqersdftaigpsVNIAARLQEATap---nSIM 178
1CJK_A    132 gvlglr-kwqfdvwsndVTLANHMEAGGka---gRIH 164
2V0N_A    424 d-----------tpealLKRADEGVYQAkasgrnAVV 449
3BRE_A    308 gg---------qtfrvlIEMADQALYQAknngrnQVG 335
3EZU_A    312 dv--------dggieelVRLADECLXQAkytgknKVV 340
1FX4_A    146 rydev--tkgydyygrtSNMAARTESVAng---gQVL 177
1YBU_A    110 rdas----hgtdvagvaVHIGARVCALAgp---sEVL 139
1Y10_A    309 ra--------gdwfgspVNVASRVTGVArp---gAVL 334
1YK9_A    116 gvvgsr-rfrycvwgdaVNVASRMESTDsv---gQIQ 148
1AB8_A    138 gvigaq-kpqydiwgntVNVASRMDSTGvl---dKIQ 170
3ET6_B    116 gvvgrk-mprfxlfgdtVNTASRMESHGea---gQIH 148

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