Conserved Protein Domain Family
nitrilase_Rim1_like

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cd07574: nitrilase_Rim1_like 
Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases)
Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143598
View PSSM: cd07574
Aligned: 40 rows
Threshold Bit Score: 300.657
Threshold Setting Gi: 220931590
Created: 21-Apr-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #                                      
gi 16766433    5 FTVSACQYIVTeinTFEDFITKVRILLNKSQg--ADVVIFPELFTIELFTllkkwqer-------------pishltlID 69
gi 206895328  39 NIVAAFNTNLRfydNALEFAHSVASYMTAALdkgAGVILFPEYFGNLLMGiagepidldd--------pstlellsmiSP 110
gi 225174247  44 IPVGAVQLEVKltdNAGEYMDEMCRITNKAArqgVRLLAFPEYSTFPLLGyipgieklaegtatdnqevsvadlfrfaGP 123
gi 167836538   5 LKVSIASFGTRryaLLHDFTTHVEELASQAQatgSEVLLLPELTSTGLLWthpeaadvtt--------ktvsefyrrvLT 76
gi 83859245  226 VRVAAIQMAMRsmeTLKEFERNVEYFVEVCSdyrADFCVFPEMFTVALLAlekrklt--------------peesiaaLS 291
gi 149374579 198 VRIGTVQYQQRrvaSFEEFSDIVRYFVDVVStykGDFVVFPELFTLQLLSiesrdgt--------------paeaieaVT 263
gi 212639156   3 MRVSAVQYHLHtiqSFEQFAKQVEHYVKTAQefgAEFVLFPEFMTTQLMSigddtke---------------altideLP 67
gi 121533988   3 LRVSAVQYHLHtikSFAEFAQQVEHYVKTAAefeADFVLFPEFVTTQLLSigdshgn---------------alsihnLP 67
gi 158521339 229 IRMCAAQYAMRpirSWEEMEESVEFFVSFADsyhCHFLVLPEYMTYQMFScmqgaem---------------kqlvadLA 293
gi 254294632 230 VRVCSVQFQMRkvnSFEEFMGQVEYFVDVASdyrSDFVCFPEFLTMPLISlskdqts--------------ssenieyLT 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                             #   #    #                 
gi 16766433   70 QFTDAYKQLFQQEAKERGQFIIaGSHLEqtgADRYENVAHIWGPDGEH-YAHSKTHIFp-aERGWYTQEGDKMAVFQLPf 147
gi 206895328 111 ILYSTYVDIFSQISAKTDATIVaGTLAFv-eNGKLVNRTFVFRRGNVI-LTQDKAHLMp-mEEKWGMSRGSRLGLFDLGt 187
gi 225174247 124 FFNRVAHFTFSKLASTFGLYIMsGSMPYp-vEDRVVNRAFLYGPDGQIlGHQDKVHLMp-mEHAWGFSAGDAFNVFDTPl 201
gi 167836538  77 PLVGEYCETLQTLAKKHGIAIA-GASFWheeDGVGRNSGWVFKPDGSV-ERQDKLHMTr-gERAISTSGGDSLTTFEIGg 153
gi 83859245  292 RHTPRFIELMSTLAVRYNINIVgGSHPTrtdDGDIQNVAYVFLRDGSV-HAQEKIHPTpneRYWWNIKGGDAVATIPTDc 370
gi 149374579 264 EYAEPFRNLMRDLALRHNINIVgGSTPVkeeDGRVRNVAYVFLRDGQV-FSQPKIHPTpneAYWWNITGGSRVTAIETDc 342
gi 212639156  68 TFTEAYRSLFSTLAKQTNMHIIgGTHVIk-rEDRLYNVAHLFYPDGTI-AEQAKLHITpteVNEWNMHGGDTLHVFDTIk 145
gi 121533988  68 DFTEQYCLLFTSLAQQTGMHIIgGTHVIr-eDERLYNVAHLFYPNGKI-VRQPKLHITpteVKEWNMAAGHDINVFETEk 145
gi 158521339 294 DMTDRYVEMFKQFAKRYRIYIIgGSTPVr-rDGRLYNTAHLFTPGGQV-HTQDKLHITpaeRAESEIEPGSHIRLFQTPl 371
gi 254294632 296 TLTDAFVEAMSEMAISYNINIIgGTHPTrveSGEIYNMAFVFLRDGSI-HTQPKIHITpseQYWCNIHGGNSLAAIETDc 374
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ## ##                    #                                               
gi 16766433  148 AKVGFNICYEAEIPECAATLAeqGVELILTPSATFTeqGFWRVRHCCHARCIENQIYLVHCCLGGNPGg---pLPGCWAR 224
gi 206895328 188 QKAGVLVCMDATYYEQSRILEnmGARLLLVPSANPApfYLGEQIRGAWARAQTSQVFTVQSFLVGKLG-----DYVFEGK 262
gi 225174247 202 GKLAMPVCMDATYFETFRILErqGAEIVMVPIANAEeyNYWLALRGIWPRVQESMVYGIKSALVGQVL-----GHTLTGK 276
gi 167836538 154 VKCGLFVCYDVQFPELTQYLVgqGVEVLLVPSLTEEr-GAWRVWHSAHARALENQLFVCVSTLVGPLDipndyQSVASGR 232
gi 83859245  371 GPVGVLICYDTEFPELARRLAdeGAKIIFAPYATDDrgGHLRVRYCAHARAIENQLYVVTAGNVGNLPgv-enMDINYAQ 449
gi 149374579 343 GPIGVLVCYDAEFPELTRHLVdqGIQILFVPFCTDErqSYLRVRYCCQARAVENQLFVIMSGNVGNLPkv-pnMELQYGQ 421
gi 212639156 146 GTIAILTCYDIEFPEIVRMARakGADVIFCPSCTDDrhGFHRVRYTCHARAIENQVYVVTTGTVGSLPtv-dfMRANFGQ 224
gi 121533988 146 GTIAILTCYDIEFPEIVRMVRakGADVIFCPSCTDDrhGFYRVRYTSHARAIENQVYVVTTGTVGSLPtv-dfMRANFGQ 224
gi 158521339 372 ARIGIQICYDIEFPEVSRLLTlaGAEVIVVPFYTEEkkAYYRVRHCAQARAVENFIYVVMAGSVGNMRtp-igSFMHYSQ 450
gi 254294632 375 GTIGVNVCYDSEFPELARNLTdqGINILFVPFSTDDrqGYNRVRYCSAARAIENQIYVVMAGTVGNMPnv-knMDINYAE 453
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                  
gi 16766433  225 SSILSPCDVVWKnpQGIIAEAHVNq-EDVISGEINLDVLYENRLggaattfKDRRRKA 281
gi 206895328 263 AGVYAPHDYTEDl-SGIVALSKKYnqEELVTAVLDYERLNRVRQp------RDFRFQA 313
gi 225174247 277 AGIFAPLELTPNq-DGTLAEAKTFdsQELVTATLDLEALHNLRAthp--ylGDQNPAL 331
gi 167836538 233 AFVACPIDNRFKvvDGTYALGAEG--EYLLNTSLDLETLRMSREksevrqlADRRPAL 288
gi 83859245  450 SAILTPCDFPFAr-DGIAAETSENv-ETIAVADLHLDDLVQARRsgtvrnlRDRRFDL 505
gi 149374579 422 SCILTPCDFPFAr-DGIAADTTPNv-ETVAFADLRPETLLTARNsgtvknlKDRRHDL 477
gi 212639156 225 AAIITPNDIPFPp-RGILAEGEINd-DMIITADIDLQLLYDVRKrgsvttwRDRRTDL 280
gi 121533988 225 AAVITPNDIPFPp-GGLLAEGEINh-DMIITADLDLELLYRVRErgsvttwRDRRTDL 280
gi 158521339 451 SAILSPSDFSFPe-KGIEGEADPNa-EAAVVSELTLSALAEQRHvatvrplHDRRADL 506
gi 254294632 454 SCILTPCDFPFAr-DGIAATSAPNt-EMVVMSDLNIETLIASRKsgtvqnlKDRRLDL 509

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