Conserved Protein Domain Family
nitrilase_6

?
cd07584: nitrilase_6 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
?
PSSM-Id: 143608
View PSSM: cd07584
Aligned: 8 rows
Threshold Bit Score: 393.658
Threshold Setting Gi: 188586226
Created: 8-May-2009
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               #                                        
gi 134299405   6 TIGLIQMDcvlgdVAANVAKAIERIRQAAamgAQIICLPELCTTGYrpdlledklw-eltepvpgptTDVFSQLAKELGI 84
gi 188586226   3 QVAAIQMTpimndVDGNIKRGVHLAKNAIaeeADLIVFPELWTTGYhlsresfra---laekpdgktVSTFQEIAKQGEV 79
gi 145953211  17 KIGIIQQHsvlgdVKKNIEKAVEMIDDLGkhgADIICLPELFATGYnleslggvktlelirehnkyiEESMSEAAKRNNV 96
gi 163814342  43 KAAAVNMDcelgnVKANLKKMADFCKEAStkgALAICFPELATTGYsptilgekyy-eisepipgpsTNYLCKVAKATGL 121
gi 85059118    3 KVALAQIDtelgnKRKNLRYIASLCKEAAdnkADVICFPELATTGYtpdllgtrlw-hlsesrgeetDQLLSQLAGELGL 81
gi 223990842   7 KVALAQFDselgnKTNNLQRMAQLCQQAAdsgAKLICFPELATTGYrgdllttklw-dlsdsigsetYTLFSELATRLNI 85
gi 227411456  14 HLALVQFEsvlcdPAANTQKACRMIAEAAaegADLVVLPELFSTGYelnivgphvp-elaepvdgptVRALQDAARAGNC 92
gi 85059456    3 TLALVQTDaylgeKRRNLERLQTFCHTAKkegAQLICFPELATTGYaptllgpeyh-alsetrqgetNRMFSALATELGV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               #   #  #                          ## ##  
gi 134299405  85 YIIlPMN--EKgavpgmiHNSAVFI--DKDGEv-qGVFRKAHAYaTERYYFTDGNh--yPVFQTefgKVGVMICYDMGFP 157
gi 188586226  80 SIVcPFV--EEagd--kiYIAAAVI--DTEGEt-rGIVRKSLLWgREQQIFNAGVme-yPTFDSkvgKIGILICYEMEFP 151
gi 145953211  97 YLIsPYGtlEKgst--hvYNSAVIF--DRKGKi-mGEYCKNHLWsLEAVYFKGGEk--vEVYDAdfgRFGVMICYDAGFP 169
gi 163814342 122 YIVtGIS--EKsgvpgrlYNSQIAI--SPEGKi-vSIYRKIHVWgLEKLTWRESItceyGTFDMpmcKAGHMICYDTSFP 196
gi 85059118   82 HIIaGFV--ERgertgqvYNSAGVW--APEGQswlHAQRKIHLWgDEKKWFSEGEq--yEIIATplgKIGVMVCYDLGFP 155
gi 223990842  86 TIVsGFV--ERgeylgdiYNSVGVWnpGCEGIs--GVFRKVHAFgIEKQWFGRGDs--fPVFETpigKIGIMICYDMGFP 159
gi 227411456  93 YVVaGLA--LAydmagvpFNSSVVI--DRQGEl-lGTYDKQHLWaLERFYFRSGCd--cPVFDTdfgRIGVMICYDMGFP 165
gi 85059456   82 IIVcGFI--ERdmqtdavYNAAGVW--LPGQEswlGVFRKMHLIqEEKRWFTPGQq--lRVFDTplgRIGGMICYDAGFP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #                                                             
gi 134299405 158 EvARILTLkgAEVIFAPSAwrqedediWDINIAARALENRLFVAAVNRVGregdvvmhGKSKIANTrGKTLAEAArfeeD 237
gi 188586226 152 EtSRLLALegAEVIVCPSVwsmsaahrWEIQLPARALDNTVFVLGVNTVGnn----scGKSKLLSPmGDVLAEASgrkeE 227
gi 145953211 170 EvSRELTLkgSEIIFIPSAwriqdedmWDLNVSQRALENTVYTVGVNLVSndsnlilfGKSKICNPrGTVITQLDtyreK 249
gi 163814342 197 EtARVLSLmgSNVIFDSAAwrnleadiWELNTRARAVENHVFMICSNRCGvegdstlnGESRIIGPrGNVLAAAGhe-eE 275
gi 85059118  156 EvARIFALrqVDILFVIAAwseaeayiWDINCAARALENGVFLVAVNRWGeegdlrlfGGSQIMAPdGQCVVRATdkgeA 235
gi 223990842 160 EvARILTLqgAELLLAPSAwcvqdrdvWDINSACRALENGTHLLAVNRWGheedlhlfGGSKVLGPrGQVLCEAScegeE 239
gi 227411456 166 EvARMLALqgADLILCPSAwcqedmdvWDVNAPARALENTAFVAAVNRYGvedqlvmpGHTKVCNPrGHVVAELAeeaeG 245
gi 85059456  156 EvARSLTLkqADSLLLLSAwpekdkdiWYINGPCRALENTIYLAAVNRWGregdcqlfGGSQILNPrGQVMARATehaeQ 235
                        250       260
                 ....*....|....*....|....*....
Feature 1                                     
gi 134299405 238 ILVATVDLHe--LIAGRRet-pYLKDRKP 263
gi 188586226 228 ILIRAIDKE---ALLWARdevsYLEDYKT 253
gi 145953211 250 YVLSEIDLD---EIKKYRedipYLKDRKS 275
gi 163814342 276 IIYADIDIDs--CIKDNAmmlsYMKDRRP 302
gi 85059118  236 LVYGNIDLS---QLANVRmtlpYRKDVKI 261
gi 223990842 240 LLIGEVDFL---NQAHTRlkvpYLRDRKP 265
gi 227411456 246 VLHVELDLN---EVVDYRqrspYLRDRRP 271
gi 85059456  236 ILYHTIDKQvqsAIRHTLp---YLADRQP 261

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap