1HXM,1YPZ,4LFH


Conserved Protein Domain Family
IgC_TCR_delta

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cd07687: IgC_TCR_delta 
Click on image for an interactive view with Cn3D
Immunoglobulin Constant domain
IgC_TCR_delta: Constant domain of the delta chain of delta/gamma T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. The majority of T cells contain alpha-beta TCRs but a small subset contain gamma-delta TCRs. Alpha-beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma-delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma-delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds.
Statistics
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PSSM-Id: 319321
View PSSM: cd07687
Aligned: 8 rows
Threshold Bit Score: 110.712
Threshold Setting Gi: 33303474
Created: 7-Jun-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
IgC heterodimerintrachain IgV
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:IgC heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ####           # # # #                                 #### # ##               
1HXM_A      129 VFVMKn--------gTNVACLVKefypkDIRINLVsskkitEFDPAIVIsp--sGKYNAVKLGKYed-snSVTCSVQHdn 197
gi 11071821 110 VFVMKn--------gTNVACLVKefypkEVTISLQsskkiiEYEPAIVVsp--gGRYSAVKLGQYnd-pdSVTCSVEHnk 178
gi 217491    81 VFVMKn--------gTNVACLVKefypkDVTISLQsskkiiEYDPAIAIsp--gGKYSAVKLGQYgd-pdSVTCSVEHnk 149
gi 33303474 147 VFVMKn--------gTNVACLVKdfypkSVDIHLPp-----EGKVIEGVvttanGKFSAVKLGQYkqdleQVKCTVKHnn 213
gi 71277041 132 IFVMKn--------gTNAACLVKdfypkSIAINLYp-----ENNTRQVVti-vnGKFSAVKFGQYtqdleNITCTVQYkn 197
gi 5802623  153 VIVMKskkhkedgdtGKAACLARnfykkNISLEMSsne-vvYEPKAPIVts--nGMYNTIKVVKVtk-qsEVTCTARLsn 228
1YPZ_E      128 VFIMKn--------gTNVACLVKdfypkEVTISLRsskkivEFDPAIVIsp--sGKYSAVKLGQYgd-snSVTCSVQHns 196
4LFH_D      129 VFVMKn--------gTNVACLVKefypkDIRINLVsskkitEFDPAIVIsp--sGKYNAVKLGKYed-snSVTCSVQHdn 197
                        90       100
                ....*....|....*....|..
Feature 1                          ###
1HXM_A      198 k--------------tvHSTDF 205
gi 11071821 179 k--------------twHSSDF 186
gi 217491   150 q--------------twHSTDF 157
gi 33303474 214 ntveafy-kmshensteKSSDL 234
gi 71277041 198 qti----------mtsyKKSNV 209
gi 5802623  229 gnftansttpemkaeeiKPANI 250
1YPZ_E      197 e--------------tvHSTDF 204
4LFH_D      198 k--------------tvHSTDF 205

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