1IJ9


Conserved Protein Domain Family
Ig_VCAM-1

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cd07689: Ig_VCAM-1 
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Immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar domains
Ig_ VCAM-1_like: immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and similar domains. During the inflammation process, these molecules recruit leukocytes onto the vascular endothelium before extravasation to the injured tissues. The interaction of VCAM-1 binding to the beta1 integrin very late antigen (VLA-4) expressed by lymphocytes and monocytes mediates the adhesion of leucocytes to blood vessel walls, and regulates migration across the endothelium. During metastasis, some circulating cancer cells extravasate to a secondary site by a similar process. VCAM-1 may be involved in organ targeted tumor metastasis and may also act as host receptors for viruses and parasites. VCAM-1 contains seven Ig domains.
Statistics
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PSSM-Id: 143313
View PSSM: cd07689
Aligned: 5 rows
Threshold Bit Score: 120.38
Threshold Setting Gi: 124100
Created: 7-Jun-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IJ9_A       92 PKDPEIHLsgpleagkpITVKCSvadvypfdrLEIDLLKGDHLMKSQefledadrksletKSLEVTFTpv--ieDIGKVL 169
gi 124100   311 SAPILTLSqpevsegdqVTVKCEah-----ggAQVVLLNSTSPRPPTsqgt-----sprpPTSQIQFTlnaspeDHKRRF 380
gi 267283   404 PEDPVIKMsgplvhgrpVTVNCTvpnvypfdhLEIELLKGETTLMKKyfleemgiksletKILETTFIpt--ieDTGKSL 481
gi 66773952 116 PKDPEIQLsgplevgkpVTVTCLvrdvypfdrLEMNLLNGNDLLQSKdflepmekksletKSLEVTFTpt--neDIGKGL 193
gi 66773952 404 PRDPEVEMsgllvdgnpVTVSCEvpnvypsdrLEIELFKGETIIESKsfledmdkksletKSLEMTFIpt--teDTGKVL 481
                        90       100
                ....*....|....*....|....
1IJ9_A      170 VCRAKLhidem-dsvpTVRQAVKE 192
gi 124100   381 FCSAALevd-----gkSLFKNQTL 399
gi 267283   482 VCLARLhsge---mesEPKQRQSV 502
gi 66773952 194 VCRAQLhmdeidfepkERETTKEL 217
gi 66773952 482 VCLAKLhide---mefEPKQRQST 502
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