1XIW


Conserved Protein Domain Family
Ig_CD3_epsilon

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cd07692: Ig_CD3_epsilon 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of CD3 epsilon chain
Ig_CD3_epsilon; immunoglobulin (Ig)-like domain of CD3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signalling once the TCR has bound an MHC/antigen complex.
Statistics
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PSSM-Id: 143316
View PSSM: cd07692
Aligned: 6 rows
Threshold Bit Score: 86.0282
Threshold Setting Gi: 62149116
Created: 29-Oct-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1XIW_A; human CD3 epsilon chain forms a heterodimer interface with CD3 delta chain, defined using 3.5 A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #   #                                                         #               ##
1XIW_A       15 YKVSISGTtVILTCpqy-pgsEILWQhndkniggdeddkNIGSDe--DHLSLkefseleqSGYYVCYPrgskpedANFYL 91
gi 115992    30 YEVSISGNsVELTCpkd-fenGIQWKrnn--------eqMKGHNe--KYLLLdqfsemesSGYYQCLAteg-nteAAHTL 97
gi 6522683   28 FAVEISGTtVTITCpss--gdDIKWKpd----------pALGDNn--KYIIQnhd---ssPLTVSCTAg-----dQEHTM 85
gi 62149116  26 GGVIFWRTsVTMTCp-----qDGKWFkdk-------tqvSQGSEyafEYDNK--------KGRYHCTYe-----nTRYDF 80
gi 50979254  41 FKVSISGTeVVVTCpdvfgydNIKWEknd--------nlVEGASn--RELSQkefsevddSGYYACYAds---ikEKSYL 107
gi 14290161  36 LQVEISGTtVKVRCsl---seTVQWKpy----------sPDTEDt--TFIKTnhd---ssPLNLTCTAd-----nKNIHM 92

                ....*
Feature 1       # ###
1XIW_A       92 YLRAR 96
gi 115992    98 YLKAR 102
gi 6522683   86 YLNAK 90
gi 62149116  81 YVQGK 85
gi 50979254 108 YLRAR 112
gi 14290161  93 YLKAR 97

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