Conserved Protein Domain Family

cd07694: Ig2_CD4 
Click on image for an interactive view with Cn3D
Second immunoglobulin (Ig) domain of CD4
Ig2_CD4; second immunoglobulin (Ig) domain of CD4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.
PSSM-Id: 143318
View PSSM: cd07694
Aligned: 3 rows
Threshold Bit Score: 124.708
Threshold Setting Gi: 2392606
Created: 26-May-2009
Updated: 18-Aug-2016
Aligned Rows:
Ig1 domainIg3 domain
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig1 domain interface [polypeptide binding site]
  • Structure:1WIO_A; human CD4 Ig2 domain forms an interchain interface with the Ig1 domain, defined using 4.0 A contacts
    View structure with Cn3D
  • Citation:PMID 8075984

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
Feature 1        #                    # #                                                        
1WIO_A        98 FGLTANSdthllqGQSLTLTLESPpg-ssPSVQCRSprgkn-----------iqggKTLSVSQlelqdSGTWTCTVlqn- 164
gi 149212630 126 FKVTATPsdyvisGTNVTLTLHGSsn--lPAFKVEWrgpgdksk-----qilnqdkKTLNLVKmgpneTGLWDCIVsv-- 196
gi 45505291  125 FKLTISSnghfltNEDLELTLMQNsshsqPHLSIKLfninndivtteilqeeapqkYILKLKQlkaidSGTWMCHVysns 204
Feature 1           ####         
1WIO_A       165 -qkKVEFKIDIVVLAF 179
gi 149212630 197 --sEKTLKLGIKVTAF 210
gi 45505291  205 psiNQNISFDVKVLGF 220

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