Conserved Protein Domain Family

cd07695: Ig3_CD4 
Click on image for an interactive view with Cn3D
Third immunoglobulin (Ig) domain of CD4
Ig3_CD4; third immunoglobulin (Ig) domain of CD4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.
PSSM-Id: 143319
View PSSM: cd07695
Aligned: 3 rows
Threshold Bit Score: 145.194
Threshold Setting Gi: 149212630
Created: 5-Jun-2009
Updated: 18-Aug-2016
Aligned Rows:
Ig4 domainIg2 domain
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig4 domain interface [polypeptide binding site]
  • Structure:1WIO_A; human CD4 Ig3 domain forms an interchain interface with the Ig4 domain, defined using 4.0 A contacts
    View structure with Cn3D
  • Citation:PMID 9168119

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
Feature 1           #### #                                                                       
1WIO_A       184 SIVYKKEgEQVEFSFPLAFTVEk---LTGSGELWWQAera-ssSKSWITFDlknkevsvkrvt-qdpklqmgkklpLHLT 258
gi 149212630 217 QTFYTMVgKAVRFSFPLNLNDQelnrEQPNGELRWNMegtaspQVVKFSWKsdsltrgtda-----ppfnrdpkfpLTIT 291
gi 45505291    9 SCVFAVIlVLQLGLTPIMAQQEqqigIAGKEVILSCKain-nqKDGTCTWKykykevsstiisfskaqvfkgkapmTHRS 87
                         90       100       110
Feature 1                ##                           
1WIO_A       259 LPqalpqyAGSGNLTLALEa------kTGKLHQEVNL 289
gi 149212630 292 LSsvspshAGSGVFLLQFS--------SGTVEQKVNL 320
gi 45505291   88 ELnsnskkLKVSDLSLDDAgiytcacySPVVSISLHV 124

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