1HXM


Conserved Protein Domain Family
IgC_TCR_gamma

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cd07697: IgC_TCR_gamma 
Click on image for an interactive view with Cn3D
T cell receptor (TCR) gamma chain constant immunoglobulin domain
IgC_TCR_gamma; immunoglobulin (Ig) constant (C) domain of the gamma chain of gamma-delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha-beta TCRs but a small subset contain gamma-delta TCRs. Alpha-beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma-delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma-delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds.
Statistics
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PSSM-Id: 319324
View PSSM: cd07697
Aligned: 4 rows
Threshold Bit Score: 145.05
Threshold Setting Gi: 1929972
Created: 17-Oct-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:IgC heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ### # ##  #    # # # #                        # #  #       # # #            
1HXM_B      132 PKPTIFLPSIAETKLqKAGTYLCLLEKFFPDVIKIHWEekks--ntilGSQEGNTMKTnd-tYMKFSWLTVpeks-ldkE 207
gi 20385982  95 PKATILSTSKKVIEKqGQGIYLCLLENFFPDAIQVVWRkgnkdipseqGEIKSEKDKDnndvYSTTSWISVtkdd-lgnK 173
gi 67846748 144 PEPIKFFPSSLEQEKqNTESYICLFKDFYPDVIRMHWKeegs--dkilESQQSDPFRVkd-kYWQMSWLTVkkss-pgkI 219
gi 1929972   70 PTIRLFPPLTAELEKsSKSFAVCLMTDFFPDVIEVQWKidgke-qkenVQTDSVTKMGtn-tYSLISRLVVtkleweskP 147
                        90       100
                ....*....|....*....|.
Feature 1                         #  
1HXM_B      208 HRCIVRHEnnkngvdqEIIFP 228
gi 20385982 174 FTCHYKHEgisk-qenWDEVS 193
gi 67846748 220 YRLIYKHEktgr-vekEELFP 239
gi 1929972  148 ISCHAKHEid----spELTIT 164

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