2ATP,3B9K,3DMM


Conserved Protein Domain Family
IgV_CD8_beta

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cd07700: IgV_CD8_beta 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig) like domain of CD8 beta chain
IgV_CD8_beta: immunoglobulin (Ig)-like domain in CD8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion and a short intracellular domain.
Statistics
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PSSM-Id: 319326
View PSSM: cd07700
Aligned: 15 rows
Threshold Bit Score: 160.685
Threshold Setting Gi: 403301
Created: 25-Oct-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2ATP_B; mouse CD8 alpha forms a heterodimer with CD8 beta, defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #   #         # #                                       
2ATP_B         8 LLVQTNHTAKMSCEVksisklTSIYWLRErqdp-kdkyFEFLASWSSs-kGVLYGEsvdkkrNIILESSdsrRPFLSIMn 85
gi 116032     29 IKVQTNKMVMLSCEAkislsnMRIYWLRQrqapssdshHEFLALWDSa-kGTIHGEev--eqEKIAVFRdasRFILNLTs 105
gi 47523316   29 VMAQTNQTVKLSCEArtfptnTRIYWLRLrqalsanshYEFLALWIPn-gNPVYGKet---eKQLTVLQdssRYLLQLRh 104
gi 674056882  26 MMVLTNQMVKLSCEMkiytksTPIYWLRQlqgptkdshFEFLVSWNPt-kGIVYGEgmtaekLTVSSDTa--QPILNLTs 102
gi 58013379   29 TTAQTNQTVTLSCEAktsptnSRIYWLRQrlapsanshFEFLAFWDLt-rGTVYGEevgqerLTVLRDSs--RYTLSLQs 105
gi 589956928  29 LTLLTNRSAKVFCEAkslpktTLIHWLRQrrgpakerrFEFLASWNPskgTSVYGEgvkkedMIMSSDIs--RYILELKs 106
gi 545186259  29 QMVQTNQMVVLTCEArttypnKRIYWLRQrqapsadshQEFLAAWDSi-kGIVYGEkl--dqEKLTLSQdasRSTLHLAh 105
gi 537136113  29 LTVLTNQVAKVSCEAktlpktTLIYWLRQrrgptkdkhFEFLASWNPskgVATPGEgv--kkESINVFSditRYILNLTs 106
gi 57619095   29 VMVQTNGMVIMSCEAktsptsTRIYWLRHrqapspdshYECLAYWDPi-kGIVYGQevepekLTVFPDAt--RSILNLTs 105
gi 351696198  29 LMVQTNQKVTMTCETktslsnKRIYWLRQrqahskdshHEFLVSEDFs-kNITYGRgvtqrtLALLRSTt--RFTLSLMh 105
                         90       100
                 ....*....|....*....|....*....
Feature 1                     #      ##       
2ATP_B        86 vkpedsDFYFCATVgspkmVFGTGTKLTV 114
gi 116032    106 vkpedsGIYFCMIVgspelTFGKGTQLSV 134
gi 47523316  105 vkpadsGNYFCMAVgnpelTFGKGTRLSV 133
gi 674056882 103 vkpedsGIYFCMIVgspelIFGKGIKLIV 131
gi 58013379  106 vkpsdsGVYFCMTVgnpdlTFGKGTQLSV 134
gi 589956928 107 vkledsGTYFCMMIgspnlIFGIGTELNV 135
gi 545186259 106 vkpedsGVYFCMIIgtpelTFGTGTRLSV 134
gi 537136113 107 vkledsGTYFCMMVgspqlIFGSGTELSV 135
gi 57619095  106 vkpadsGIYFCMTVgspelTFGKGTRLSV 134
gi 351696198 106 vkpedsGVYFCMTMgapelIFGTGTSLSV 134

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