Conserved Protein Domain Family
Ig2_Nectin-3-4_like

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cd07704: Ig2_Nectin-3-4_like 
Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
Ig2_Nectin-3-4_like: domain similar to the second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and nectin-4 (poliovirus receptor related protein 4). Nectin-3 and nectin-4 belong to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through 4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. Nectin-3 has also been shown to form a heterophilic trans-interaction with nectin-1 in ciliary epithelia, establishing the apex-apex adhesion between the pigment and non-pigment cell layers. Nectin-4 has recently been identified in several types of breast carcinoma and can be used as a histological and serological marker for breast cancer.
Statistics
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PSSM-Id: 319329
View PSSM: cd07704
Aligned: 4 rows
Threshold Bit Score: 150.427
Threshold Setting Gi: 156633583
Created: 3-May-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761016  149 PLPSLNPGpale-egqgLTLAASCTAE-GSPAPSVTWDtevkGTTSSRSFKHSr-SAAVTSEFHLVpsrsMNGQPLTCVV 225
gi 156633583 147 PLPTLGPGpplt-egegKSLAASCTAE-GNPAPTLTWEtdveGTNTTQKYEHPr-SSSVTSEFYVVptrrMNGKPLTCVV 223
gi 134054338 151 PKVYVSAGssalidggnETTVATCIAErARPPADVSWEtnlyGMSEAHMQEDAngTTTTQVHYIWQpsrhAQGHTLTCVV 230
gi 118083628 176 PVVSLTKGpnplidganQTIAAICTAAtGKPAAEIDWEgg-lGEMESSSTLFPneTVTVISQYTIIptrfARGRRITCIV 254
                         90
                 ....*....|....*..
gi 74761016  226 SHPGllQDQRITHILHV 242
gi 156633583 224 SHPGfqQEKRITHVLQV 240
gi 134054338 231 KHPAlqSDFRIPYIINV 247
gi 118083628 255 RHPAleKEIRFSHVLDI 271
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