Conserved Protein Domain Family
Ig2_Necl-1

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cd07705: Ig2_Necl-1 
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Ig2_Necl-1: second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.
Statistics
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PSSM-Id: 143329
View PSSM: cd07705
Aligned: 3 rows
Threshold Bit Score: 157.845
Threshold Setting Gi: 126307328
Created: 2-Jul-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21708058  147 TATLNCQSSgsKPAARLTWRkgdqelhgeptriqedpngkTFTVSSSVTFQvtreDDGASIVCSVNHESLkgadRSTSQR 226
gi 147901041 142 KAKLRCTTSgsKPAANIKWYkgpeelegaktsvledgngkTFTVKSFIEFDvtkdDDGAEITCAVGHESLhdsaKSSSHK 221
gi 126307328 153 KAHLTCLSKgsKPAAEISWRkgdqelkgkp-lmvqedvnkTFTVSSSVEFQvfreDDGVDVTCSVKHKSLqdmdRSTSQR 231

                 ...
gi 21708058  227 IEV 229
gi 147901041 222 IQV 224
gi 126307328 232 IEV 234
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