2AK4,1TVD


Conserved Protein Domain Family
IgV_TCR_delta

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cd07706: IgV_TCR_delta 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain
IgV_TCR_delta: immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor.
Statistics
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PSSM-Id: 319330
View PSSM: cd07706
Aligned: 6 rows
Threshold Bit Score: 185.78
Threshold Setting Gi: 3114261
Created: 6-Nov-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
IgV heterodimerantigen/MHCL1L2L3
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:IgV heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1TVD_A; human gamma/delta T cell receptor delta chain IgV domain forms a heterodimer interface with the gamma chain IgV domain, defined using 4.0 A contacts
    View structure with Cn3D
  • Citation:PMID 8976572

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          # # #   # # #  #                              
2AK4_D         5 KVTQaqteISVVEKEDVTLDCVYETRd--TTYYLFWYKQPPSGELVFLIRRNSfdeq--neisGRYSWNFQkstSSFNFT 80
1TVD_A         2 KVTQsspdQTVASGSEVVLLCTYDTVy--SNPDLFWYRIRPDYSFQFVFYGDDsrsegadftqGRFSVKHIltqKAFHLV 79
gi 2243       23 KVTQdqsdVSSQVGQSVTLNCRYETSw--TAYYIFWYKQLPSGQMTYVIRQSSlvtn---atkDRYSINFKkadKSISLT 97
gi 1041147    23 KVTQdqpvVSRQVGEEVTLNCRYETSw--NEYILFWYKQPPSGEMTFLIRQESkgln---tkdGRYSTNFQkaqNLISLT 97
gi 151554330  57 QVTQvqtvVSSQVGQTVTLNCRYEVSwsmDYYYIFWYKQLPRGEMTFLIHQYSeygn---arnGRYSVNFHkahKSISLI 133
gi 34100333   23 KVTQaqssVSMPVRKAVTLNCLYETSw--WSYYIFWYKQLPSKEMIFLIRQGSdeqn---aksGRYSVNFKkaaKSVALT 97
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                    #                        ## # ##       
2AK4_D        81 ITASQvVDSAVYFCALSGFyn--------------tDKLIFGTGTRLQVFP 117
1TVD_A        80 ISPVRtEDSATYYCAFTLPpp--------------tDKLIFGKGTRVTVEP 116
gi 2243       98 ISALQlEDSAKYFCALSVSytnsegftsgvhyvrdtDKLTFGKGTRLIVEP 148
gi 1041147    98 ISALQlQDSAKYFCALRDGlwgysgg---ivtrydtDKLIFGKGTQLVVEP 145
gi 151554330 134 ISALQlGDSAEYFCALFSRrrdsr-------swyetDKLIFGKGTRLIVEP 177
gi 34100333   98 ISALQlEDSAKYFCALGELgd--------------tDKLIFGKGTRVTVEP 134

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