Conserved Protein Domain Family

cd07765: KRAB_A-box 
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KRAB (Kruppel-associated box) domain -A box.
The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
PSSM-Id: 143639
View PSSM: cd07765
Aligned: 113 rows
Threshold Bit Score: 39.8402
Threshold Setting Gi: 194379322
Created: 30-Sep-2008
Updated: 17-Jan-2013
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
1V65_A         8 VTYDDVHMNFt-----eEEWDLLd----------sSQKRLYEEVMLETYq--NLTDI 47
gi 111306672 129 VTTEEVAGCFp------EQQEGSpe---------dWQKELCKRVAKERHe--VLGSL 168
gi 74757253  227 EPVKDVHVARgfs--yrKSVHQIp-----------AQRDLYRDFRKENVg--NVVSL 268
gi 134044257  72 VNFKIVTVDFt-----rEEQGTWn----------pAQRTLDRDVILENHr--DLVSW 111
gi 149572571 305 RTFEDLAVRFs-----qERWEQPd----------pAQRELYRDIGRENYg--NEGAL 344
gi 194220798 552 VKFCDLAVLLpcvsrelQEMVTLvdssggvglldpSQRRLCREVMLEKIs--RLVSQ 606
gi 71153482   14 ILFEDLAVYFs-----qEECVTLh----------pAQRSLSKDGTKESLedaALMGE 55
gi 149640210  17 VLFEDLAVYFs-----qEECVNLq----------pIQRDSCKDARWEMYk--EMFPL 56
gi 11136143  218 EEVADVAVSFi-----lEEWGHLd----------qSQKSLYRDDRKENYg--SITSM 257
gi 119592871 232 VTIKNLAVDF-------RQQLHP------------AQKNFCKNGIWENNs--DLGSA 267
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