2PK9,2PMI


Conserved Protein Domain Family
STKc_Pho85

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cd07836: STKc_Pho85 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143341
View PSSM: cd07836
Aligned: 8 rows
Threshold Bit Score: 560.176
Threshold Setting Gi: 19075421
Created: 24-Sep-2008
Updated: 2-Mar-2014
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ####    #            # #               #             #               ####
2PK9_A         6 QFKQLEKLGNGTYATVYKGLNKttgVYVALKEVKLDSEEGTPSTAIREISLMKELkHENIVRLYDVIHTEnKLTLVFEFM 85
2PMI_A         6 QFKQLEKLGNGTYATVYKGLNKttgVYVALKEVKLDSEEGTPSTAIREISLMKELkHENIVRLYDVIHTEnKLTLVFEFM 85
gi 5081691     9 SFQQLEKLGEGTYATVFKGRNRhtgEFVALKEIHLDSEEGTPSTAIREISLMKELkHENIVALHDVIHTEsKLMLVFEYM 88
gi 19075421    2 NYQRLEKLGEGTYAHVYKGQNRvtgEIVALKVIRIDADEGTPSTAIREISLMKELrHPNIMSLSDVLQTEnKLMLVFEYM 81
gi 122893693   2 NYVQLEKLGEGTYATVYKGRSRlnnEIVALKEIHLDAEEGTPSTAIREISLMKELrHTNIVRLYDVIHTEsKLMLVFEYM 81
gi 20138890    2 NYQRLEKLGEGTYAHVYKGQNRvtgEIVALKVIRIDADEGTPSTAIREISLMKELrHPNIMSLSDVLQTEnKLMLVFEYM 81
gi 57228480    2 NYVQLEKLGEGTYATVYKGRSRttsEIVALKEIHLDAEEGTPSTAIREISLMKELkHVNIVRLHDVVHTEsKLVLIFEYC 81
gi 145229321   9 SFKKLEKLGQGTYATVYKGRNRetnELVALKEINLDAEEGAPSTAIREVSLLRRLtHENILTLHDVINVEdKLVLVFEYM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # ##                                         # # ## #          #  #           
2PK9_A        86 DNDLKKYMDSRtvgntprGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINkrGQLKLGDFGLARAFGIPVNTF 165
2PMI_A        86 DNDLKKYMDSRtvgntprGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINkrGQLKLGDFGLARAFGIPVNTF 165
gi 5081691    89 DGDLKKYMDTNge---rgALKPMLIKSFMYQLLKGIDFCHQNRVLHRDLKPQNLLINgkGQLKLGDFGLARAFGIPVNTF 165
gi 19075421   82 EKDLKKYMDTYgn---qgALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINsrGELKLADFGLARSIGIPVNTF 158
gi 122893693  82 EQDLKKYMEIHgh---rcALDPVTTRSFMFQLLKGTAFCHENRVLHRDLKPQNLLINkrGELKLADFGLARAFGIPVNTF 158
gi 20138890   82 EKDLKKYMDTYgn---qgALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINsrGELKLADFGLARSIGIPVNTF 158
gi 57228480   82 EQDLKRYMDIHgd---rgALDLNTVKSFTHQLLQGIAFCHDHRVLHRDLKPQNLLINkrGELKIGDFGLARAFGVPVNTF 158
gi 145229321  89 DKDLKRYIDTHg-----gPLDAATAKSFVYQLLRGVSFCHENGILHRDLKPENLLLNqdGRLKLADFGLGRAFGIPISKF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #### #                                     ##                                 
2PK9_A       166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTnDEEQLKLIFDIMGTPNESLWPSVt-KLPKYN- 243
2PMI_A       166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTnDEEQLKLIFDIMGTPNESLWPSVt-KLPKYN- 243
gi 5081691   166 SNEVVTLWYRAPDVLLGSRTYNTSIDIWSVGCIMAEMYTGRPLFPGTtNEDQMLRIFRIMGTPTEHNWPGIs-QFPEYK- 243
gi 19075421  159 SNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSnNEDQLLKIFRLLGTPTEQSWPGIs-LLPEYK- 236
gi 122893693 159 SNEVVTLWYRAPDVLLGSRTYSTSIDVWSAGCIMAEMISGLPLFRGRdNNDQLNQILRILGTPDDNTMKRLvnDSPEIQm 238
gi 20138890  159 SNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSnNEDQLLKIFRLLGTPTEQSWPGIs-LLPEYK- 236
gi 57228480  159 SNEVVTLWYRAPDVLLGSRTYSTSIDIWSVGCIFAEMITGYPLFRGRdNADQLVQIMKIVGTPSDATIAQIklNSPEIQ- 237
gi 145229321 164 SSDVVTLWYRPPDVLLGSRTYTTSIDIWSVGCIMAEIYTGSALFTGTtNADQLLKIFNIMGTPTELTWPGVs-QLPEYR- 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
2PK9_A       244 PNIQQRPPRDLr-QVLQPhtkepldGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297
2PMI_A       244 PNIQQRPPRDLr-QVLQPhtkepldGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297
gi 5081691   244 ATAPRYATQDL--RQILPqi----dATGIDLLQRLLQLRPELRISAHDALQHPWF 292
gi 19075421  237 PTFPIYKAQDL--AYLFPtf----dPLGLDLLRRMLRLQPELRTTGQDALQHAWF 285
gi 122893693 239 RAFPRVPRVPF--QNMFPka----hPLAIDLLDKLLKFDPTQRISADEALRHPYF 287
gi 20138890  237 PTFPIYKAQDL--AYLFPtf----dPLGLDLLRRMLRLQPELRTTGQDALQHAWF 285
gi 57228480  238 IKSPLAKHAKQpfQAIIPra----pRDAISLLEHLLQFEPTRRYDAHQAMAHQYF 288
gi 145229321 242 NDFPPCSPQSL--QQLIPsl----dPVGIDLLGRMLQLCPEARISATDALNHPWF 290

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