1OWR,1A66,1P7H


Conserved Protein Domain Family
RHD-n_NFAT

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cd07881: RHD-n_NFAT 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.
Statistics
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PSSM-Id: 143641
View PSSM: cd07881
Aligned: 15 rows
Threshold Bit Score: 367.6
Threshold Setting Gi: 125806437
Created: 31-Jul-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #  # ## ###                                              
1OWR_M          4 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 83
1P7H_M          6 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 85
gi 94734354   350 DWQLPSSSGPYSLQIDVQPKSHHRAHYETEGSRGAVKALAGGHPVVQLHGYMesePLTLQLFIGTADDRllRPHAFYQVH 429
gi 118100895  398 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 477
gi 189520514  325 DWPLPCSSGQYELRIEAQPRQHHRAHYETEGSRGAVKASSGGHPVVQLRGYTgtePLVLQIFIGTADDRnlRPHAFYQVH 404
gi 125806437  258 DWPLPSQFDQYELRIEVQPRPHHRAHYETEGSRGAVKASPGGHPVVKLVGYTerqPLSLQVFVGTADDRsiRPHPFYQIH 337
gi 209862845  470 DWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSe-kPLTLQMFIGTADERnlRPHAFYQVH 548
gi 213982749  407 DWALPSRYGQYELKVDVQPKTHHRAHYETEGSRGAVKAVTGNHPIVKLTGYTe-kPLNLQMFIGTADDRyvRPHAFYQVH 485
gi 9087154    421 DWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSe-kPINLQMFIGTADDRylRPHAFYQVH 499
gi 118096263  543 DWPLPSHYGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSe-kPVNLQMFIGTADDRylRPHAFYQVH 621
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                        # ##             ## #                 
1OWR_M         84 RITGKTVTTTSYEKIVGNTKVLEIPLEPknNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 160
1P7H_M         86 RITGKTVTTTSYEKIVGNTKVLEIPLEPknNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 162
gi 94734354   430 RITGKTVSTPSHEVLQSNTKVLEIPLLPesNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRMVFRVHINQPn--- 506
gi 118100895  478 RITGKTVTTTSYEKIIGNTKVLEIPLEPknNMKATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 554
gi 189520514  405 RITGKTVTTNSQDRMLNGTKILEVPMEPkeNMRAVIDCAGILKLRNADIELKKGETDVGRKNTRVRLVFRVHIPQPg--- 481
gi 125806437  338 RVTGKMVGTASQESIQAGTKILDIPLNPenNMTALIDCAGILKLRNSDIELRKGETDVGRKNTRVRLVFRTHLPLSqpiv 417
gi 209862845  549 RITGKMVATASYEAVVSGTKVLEMTLLPenNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGg--- 625
gi 213982749  486 RITGKTVATASQEIVITNTKVLEIPLLPenNMTASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQTs--- 562
gi 9087154    500 RITGKTVATASQEIIIASTKVLEIPLLPenNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPs--- 576
gi 118096263  622 RITGKTVATASQEIIIASTKVLEIPLLPenNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQTs--- 698
                         170       180
                  ....*....|....*....|
Feature 1                           # 
1OWR_M        161 --GRIVSLQTASNPIECSQR 178
1P7H_M        163 --GRIVSLQTASNPIECSQR 180
gi 94734354   507 --GRTVSLQVASNPIECSQR 524
gi 118100895  555 --GRIISLQAASNPIECSQR 572
gi 189520514  482 --GQWLSLQVASQTIECSQR 499
gi 125806437  418 ppGRVLALQVASLPIECSQR 437
gi 209862845  626 --GKVVSVQAASVPIECSQR 643
gi 213982749  563 --GKVLSLQAASVPIECSQR 580
gi 9087154    577 --GKVLSLQIASIPVECSQR 594
gi 118096263  699 --GKVLSLQTASIPVECSQR 716

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