1IMH


Conserved Protein Domain Family
RHD-n_TonEBP

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cd07882: RHD-n_TonEBP 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.
Statistics
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PSSM-Id: 143642
View PSSM: cd07882
Aligned: 7 rows
Threshold Bit Score: 294.806
Threshold Setting Gi: 198427155
Created: 31-Jul-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  # ######                                                        
1IMH_C         17 KELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNePVVLQVFVGNDSg-RVKPHGFYQACRVTGRNTTPCK 95
gi 75022212   255 VQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDkVAVLQVFIGTDIg-RVAPHMFYQACKVAGKNSTQCN 333
gi 198446415  204 KELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNePVVLQVFVGNDSg-RVKPHGFYQACRVTGRNTTPCK 282
gi 219434177   15 MQLKILKQPEVHHRARYMTEGSRGSVKDESGHGFPTVKLEGCNkSATLQVFVGTDTg-KIKPHGFYQACKVTGRNTTPCT 93
gi 41054033   266 KELKILVQPETQHRARYLTEGSRGSVKDRTQQGFPTIKLDGVSdPVVLQVFVANDAg-RVKPHGFYQACRVTGRNTTACK 344
gi 198427155  346 CSLSIVNQPEPQHRARYLTEGSRGPVKDSSQQGYPQIELKGYTgKTTLLVYVGSESddKIRPHGFYQACKVTGRNTTACE 425
gi 115974430  228 GEIHITVQPEKHHRARYRTEGSRGSVKDDSGENFPKLKLLGINqQVLLQVFVVTDQg-KVRPHGYYQACKVTGRNTTPSE 306
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        # ##                 # #                         
1IMH_C         96 EVDIEGTTVIEVGLDPs-nNMTLAVDCVGILKLRNADVEARIgia---gsKKKSTRARLVFRVNIMRkd-----gSTLTL 166
gi 75022212   334 EKKVDGTMVIEIDFKPe-tDMTITCDCVGILKERNVDVEHRFpehlaqknKKKSTRCRMVFRTQLTRdd-----gTTETL 407
gi 198446415  283 EVDIEGTTVIEVGLDPs-nNMTLAVDCVGILKLRNADVEARIgia---gsKKKSTRARLVFRVNITRkd-----gSTLTL 353
gi 219434177   94 ERDIEGTTVIEVPLDPt-nNMTQSLDCVGILKLRNADVEARIgla---rsKRRSTRCRLVFRVHIPRed-----gSLLTL 164
gi 41054033   345 EVDIEGTTVIEVNLEPt-nSMTLPVDCVGILKLRNADVEARIgva---gsKKKSTRARLAFRVNIPRpd-----gSILTL 415
gi 198427155  426 EVEVEGTKVIHIPFDA---QEIISVDCVGILKLRNADVEARIgis---raKKRSQTVRLVFRVILNDiersdgctPPLVL 499
gi 115974430  307 EKDVEGTTVLEVPWEPvdgKMEISVDCIGILKLRNADVEQRIgpl---rsKRKSTCVRLAFRVIVPAsd-----gSFNVV 378
                         170
                  ....*....|.
Feature 1                   #
1IMH_C        167 QTPSSPILCTQ 177
gi 75022212   408 QVCSNPIICTQ 418
gi 198446415  354 QTPSSPILCTQ 364
gi 219434177  165 QCHSTPIICSE 175
gi 41054033   416 QTLSSPILCTQ 426
gi 198427155  500 QVVSNRINCTQ 510
gi 115974430  379 QTVSRSITCTQ 389

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