1VKX,2O61


Conserved Protein Domain Family
RHD-n_RelA

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cd07885: RHD-n_RelA 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of RelA
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.
Statistics
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PSSM-Id: 143645
View PSSM: cd07885
Aligned: 5 rows
Threshold Bit Score: 330.679
Threshold Setting Gi: 190338173
Created: 31-Jul-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # ## ## ####                                                      
1VKX_A         1 AYVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTTKTHPTIKINGYTgPGTVRISLVTKDPPHRPHPHELVGKDCRdG 80
gi 548721     18 PPVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTSKTHPTIKINNYQgPARIRISLVTKDSPHKPHPHELVGKDCKdG 97
2O61_A         2 GYVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTTKTHPTIKINGYTgPGTVRISLVTKDPPHRPHPHELVGKDCRdG 81
gi 45384100   25 PFVEILEQPKQRgMRFRYKCEgRSAGSIPGEHSTDSARTHPTIRVNHYRgPGRVRVSLVTKDPPHGPHPHELVGRHCQhG 104
gi 190338173  18 PHVEIIEQPKSRgMRFRYKCEgRSAGSIPGEKSNDTTKTHPAIRVHNYSgPVRVRISLVTKNQPYKPHPHELVGKDCKhG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               ###                                                      
1VKX_A        81 YYEADLCpDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEeq-rgDYDLNAVRLCFQVTVRdpa-grpLLLT 158
gi 548721     98 YYEAELSpDRSIHSFQNLGIQCVKKREVEDAVAHRIRTNNNPFNVSPEel-kaDYDLNTVCLCFQVFIPdqaagrmLPLP 176
2O61_A        82 FYEAELCpDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEeq-rgDYDLNAVRLCFQVTVRdps-grpLRLP 159
gi 45384100  105 YYEAELSpERCVHSFQNLGIQCVKKRELEAAVAERIRTNNNPFNVPMEer-gaEYDLSAVRLCFQVWVNgpg--glCPLP 181
gi 190338173  98 YYEADLQ-ERRIHSFQNLGIQCVKKKDVGEAVSCRLQTQNNPFKIPDAkiweeEFDLNAVRLCFQVSITlss-gdlFPLE 175
                        170
                 ....*....|.
Feature 1                  #
1VKX_A       159 PVLSHPIFDNR 169
gi 548721    177 FVVSQPIYDNR 187
2O61_A       160 PVLSHPIFDNR 170
gi 45384100  182 PVLSQPIYDNR 192
gi 190338173 176 PVVSQPIYDNR 186

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