Conserved Protein Domain Family
CRD_corin_2
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cd07888: CRD_corin_2 
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease .
The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This model characterizes the second (C-terminal) CRD.
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Statistics
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PSSM-Id: 143579
Aligned: 3 rows
Threshold Bit Score: 246.466
Created: 3-Aug-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # ##  ###                                                               
Q9Y5Q5        454 QCEPITLeLCMNlpYNSTSYPNYFGHrtqkeASISWESSLfpaLVQTNCYKyLMFFSCTILVPKCDvntgerIPPCRALC 533  human
XP_002194212  684 QCEPITLeLCMNlpYNYTYYPNYLGHrtqkeASISWESSLfpaLVQTNCYKyLMFFACTILVPKCDphtnqrIPPCRTLC 763  zebra finch
CAQ13859      317 DCEPISLeICMNlpYNTTRFPNYLGHqsqkeTSVSWESSLfpaLVQTNCYKyLMFFACTVLVPMCDpvtqqrVPPCRSLC 396  zebrafish

Feature 1                                                   
Q9Y5Q5        534 EhskerCESVLGIVGLqwpedtDCSQFPeensdnqtCLMPDE 575  human
XP_002194212  764 VqskerCEAVLGIVGLqwpedtDCTQFPdensdnqtCLTPDE 805  zebra finch
CAQ13859      397 RnskdrCESVLGIVGLqwpedtDCAQFPeegqanssCLLPDP 438  zebrafish

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