Conserved Protein Domain Family
CRD_corin_2

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cd07888: CRD_corin_2 
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease .
The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This model characterizes the second (C-terminal) CRD.
Statistics
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PSSM-Id: 143579
View PSSM: cd07888
Aligned: 3 rows
Threshold Bit Score: 246.466
Threshold Setting Gi: 224049931
Created: 3-Aug-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # ##  ###                                                               
gi 13878447   454 QCEPITLeLCMNlpYNSTSYPNYFGHrtqkeASISWESSLfpaLVQTNCYKyLMFFSCTILVPKCDvntgerIPPCRALC 533
gi 224049931  684 QCEPITLeLCMNlpYNYTYYPNYLGHrtqkeASISWESSLfpaLVQTNCYKyLMFFACTILVPKCDphtnqrIPPCRTLC 763
gi 169145903  317 DCEPISLeICMNlpYNTTRFPNYLGHqsqkeTSVSWESSLfpaLVQTNCYKyLMFFACTVLVPMCDpvtqqrVPPCRSLC 396
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
Feature 1                                                   
gi 13878447   534 EhskerCESVLGIVGLqwpedtDCSQFPeensdnqtCLMPDE 575
gi 224049931  764 VqskerCEAVLGIVGLqwpedtDCTQFPdensdnqtCLTPDE 805
gi 169145903  397 RnskdrCESVLGIVGLqwpedtDCAQFPeegqanssCLLPDP 438

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