1OWR,1IMH,1P7H


Conserved Protein Domain Family
RHD-n_NFAT_like

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cd07927: RHD-n_NFAT_like 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.
Statistics
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PSSM-Id: 143648
View PSSM: cd07927
Aligned: 4 rows
Threshold Bit Score: 251.424
Threshold Setting Gi: 156382417
Created: 14-Sep-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  # ######                                                        
1OWR_M        14 YELRIEVQPKPHHRAHYETEGSRGAVKAP-TGGHPVVQLHGYMenkPLGLQIFIGTADerilKPHAFYQVHRItgktvtt 92
1IMH_C        17 KELKIVVQPETQHRARYLTEGSRGSVKDRtQQGFPTVKLEGHNe--PVVLQVFVGNDSgr-vKPHGFYQACRVtgrn-tt 92
1P7H_M        16 YELRIEVQPKPHHRAHYETEGSRGAVKAP-TGGHPVVQLHGYMenkPLGLQIFIGTADerilKPHAFYQVHRItgktvtt 94
gi 156382417 517 PKLVLLEEPEENYRARYESEGCRGPIHGSsDNTFPTVKVLGYSg--SVWITVHLVTSSg---QPHYHSIHGPGstk---v 588
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             # ##                  ## #                 
1OWR_M        93 tSYEKI----VGNTKVLEIPLEpknnMRATIDCAGILKLRNADIELrkge-----tdigRKNTRVRLVFRVHIPEss-gR 162
1IMH_C        93 pCKEVD----IEGTTVIEVGLDpsnnMTLAVDCVGILKLRNADVEArigi-----agskKKSTRARLVFRVNIMRkd-gS 162
1P7H_M        95 tSYEKI----VGNTKVLEIPLEpknnMRATIDCAGILKLRNADIELrkge-----tdigRKNTRVRLVFRVHIPEss-gR 164
gi 156382417 589 pCKEFLlpgeIPAVQVLVEPDCd---MTAILDSLSIRRLRNWEGDKelkkrgidprtwkKERKEARLLFQADIPAkdglP 665
                        170
                 ....*....|....*
Feature 1                      #
1OWR_M       163 IVSLQTASNPIECSQ 177
1IMH_C       163 TLTLQTPSSPILCTQ 177
1P7H_M       165 IVSLQTASNPIECSQ 179
gi 156382417 666 EMKLSCKSRIFQCSS 680

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