Conserved Protein Domain Family
MhqB_like_N

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cd08344: MhqB_like_N 
N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins
This subfamily contains the N-terminal, non-catalytic, domain of Burkholderia sp. NF100 MhqB and similar proteins. MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion. The purified enzyme has shown extradiol ring cleavage activity toward 3-methylcatechol. Fe2+ was suggested as a cofactor, the same as most other enzymes in the family. Burkholderia sp. NF100 MhqB is encoded on the plasmid pNF1. The type I family of extradiol dioxygenases contains two structurally homologous barrel-shaped domains at the N- and C-terminal. The active-site metal is located in the C-terminal barrel and plays an essential role in the catalytic mechanism.
Statistics
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PSSM-Id: 319932
View PSSM: cd08344
Aligned: 7 rows
Threshold Bit Score: 177.993
Threshold Setting Gi: 58616650
Created: 23-Sep-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36958918   20 HSLDTFSFGVPDLDKAEEFHRAFGLVTRERgGALELRTEgnDHVWARLTEGp-kKALSYLSFGIYEeDLERFKRHLKSNG 98
gi 3644005     3 SSLLHVGILVPDLEVGRAFYELFGLEARAVgNDLVFRCPgrDQDQIRLIQGa-kKRLAYVSLGTNGpGMATLMSRLNAAG 81
gi 58616650    3 RSLLHVGILVPDLEVGRAFYELFGLEARAVgNDLVFRCPgrDQDQIRLIQGa-kKRLAYVSLGTNGpGMATLMSRLNAAG 81
gi 193788998  13 HSVDEFVFSVPDIEEARRFYSNFGLDVRDEgEYLALYTHghPQRWARIRQGd-rKRLLWLSMGIHAsDAERFAAHLDSQG 91
gi 77539314   14 HSIDHFALEVPDLSAAKVFFGAFGLAVDETiDGLELRASasDHVWARVLKGs-rKQLAYLSLNCFGdDLAALTAQVETAG 92
gi 1304487    17 HSIDHFAVEVPDLEAARTFYTLFGLDVRERdDTLELYAFgnPHRWAVLSQGgdaKRLRYLSFGIYPdEADAFAAHLDGCG 96
gi 127273     24 HSIDHYALEVPDLAVAERFLDAFGLTVARTpECLEVYAAd-QRCWARFYEGe-rKRLAYLSFSCFEgDFAGIRQQLAASG 101
                         90       100       110
                 ....*....|....*....|....*....|....
gi 36958918   99 VLETdap-pgLESNGIWLRDFEGTLVELKVAAKS 131
gi 3644005    82 VALSsnppfdVGLDGVWFQDPHGDWLNVRVAEPA 115
gi 58616650   82 VALSsnppfdVGLDGVWFQDPHGDWLNVRVAEPA 115
gi 193788998  92 IARIaap-pgADPGGLWIEAPDGLALQLRIARKS 124
gi 77539314   93 GKPCaahagaHDPEGFWFEDPDGNRLQIRTGDKT 126
gi 1304487    97 VTRIdpp-egAEADGIWFAGFDGLPINVRVADKA 129
gi 127273    102 ATLVedp-ryGDESGVWFFDPDGNLVQVKIGPKT 134
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